Merck
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SRP6541

Sigma-Aldrich

FNDC4

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(s):
Fibronectin Type III Repeat-containing Protein 1, Fibronectin Type III Domain-containing Protein 4
NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

ensayo

≥95% (SDS-PAGE)

formulario

lyophilized

mol peso

~160 kDa (Extracellular domain, human aa 45-167 / mouse aa 41-163 is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.)

envase

pkg of 10 μg

impurezas

<0.1 EU/μg endotoxin (LAL test)

Nº de acceso UniProt

enviado en

wet ice

temp. de almacenamiento

−20°C

Gene Information

human ... FNDC4(64838)

Descripción general

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.

Forma física

Lyophilized in PBS.

Reconstitución

Reconstitute with 100 μL sterile distilled water.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

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Certificate of Origin

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