Merck
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SRP6548

Sigma-Aldrich

ApoJ/Clusterin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):
AAG4, CLI, Clusterin Apolipoprotein J, KUB1, MGC24903, SGP-2, SGP2, TRPM2
NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

ensayo

≥90% (SDS-PAGE)

formulario

lyophilized

mol peso

51.1 kDa (23-449 aa with a C-terminal His-tag.)

envase

pkg of 1 mg
pkg of 10 μg
pkg of 50 μg

Nº de acceso UniProt

enviado en

wet ice

temp. de almacenamiento

−20°C

Gene Information

human ... CLU(1191)

Descripción general

Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.

Forma física

Lyophilized from 2 mg/mL solution of ApoJ in 25 mM Na2HPO4 and 100 mM NaCl (pH 7.5).

Reconstitución

Reconstitute in dH2O to a working concentration of 0.5 mg/mL and let the lyophilized pellet dissolve completely.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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