SRP6548

Sigma-Aldrich

ApoJ/Clusterin human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinónimos:
Clusterin Apolipoprotein J, SGP2, TRPM2, SGP-2, CLI, KUB1, AAG4, MGC24903
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

human

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

lyophilized

mol wt

51.1 kDa (23-449 aa with a C-terminal His-tag.)

packaging

pkg of 1 mg
pkg of 10 μg
pkg of 50 μg

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CLU(1191)

General description

Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.

Physical form

Lyophilized from 2 mg/mL solution of ApoJ in 25 mM Na2HPO4 and 100 mM NaCl (pH 7.5).

Reconstitution

Reconstitute in dH2O to a working concentration of 0.5 mg/mL and let the lyophilized pellet dissolve completely.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

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