Merck
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SRP6558

Sigma-Aldrich

Cathepsin K Active from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):
CTSK, CTSO, CTSO3
NACRES:
NA.32

origen biológico

mouse

recombinante

expressed in E. coli

ensayo

≥90% (SDS-PAGE)

formulario

liquid

mol peso

23.4 kDa (115-329 aa)

envase

pkg of 5 μg
pkg of 50 μg

concentración

0.5 mg/mL

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

mouse ... CTSK(13038)

Descripción general

Cathepsin K belongs to the peptidase C1 protein family and is a lysosomal cysteine protease. The associated gene is strongly expressed on osteoclasts and is also present in cardiomyocytes. Cathepsin K is the most abundant and main protease involved with osteoclastic activity.

Acciones bioquímicas o fisiológicas

Cathepsin K is responsible for collagenolytic and elastolytic activities. It can degrade type II collagen and thus participates in the degradation of articular cartilage. It also plays an important role in osteoarthritis and periodontitis. Removal of the cathepsin K activity provides protection against agents inducing metabolic stress in the heart. Absence of cathepsin K also protects from age-related decline in cardiac function by inhibition of caspase-associated and caspase-independent cell death.

Forma física

0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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