SRP6558

Sigma-Aldrich

Cathepsin K Active from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sinónimos:
CTSO3, CTSO, CTSK
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

mouse

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

liquid

mol wt

23.4 kDa (115-329 aa)

packaging

pkg of 5 μg
pkg of 50 μg

concentration

0.5 mg/mL

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

mouse ... CTSK(13038)

General description

Cathepsin K belongs to the peptidase C1 protein family and is a lysosomal cysteine protease. The associated gene is strongly expressed on osteoclasts and is also present in cardiomyocytes. Cathepsin K is the most abundant and main protease involved with osteoclastic activity.

Biochem/physiol Actions

Cathepsin K is responsible for collagenolytic and elastolytic activities. It can degrade type II collagen and thus participates in the degradation of articular cartilage. It also plays an important role in osteoarthritis and periodontitis. Removal of the cathepsin K activity provides protection against agents inducing metabolic stress in the heart. Absence of cathepsin K also protects from age-related decline in cardiac function by inhibition of caspase-associated and caspase-independent cell death.

Physical form

0.5 mg/mL solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Deficiency of cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role.
Hao L, et al.
Febs Letters, 589, 1331-1331 (2015)
In vivo fluorescence reflectance imaging of protease activity in a mouse model of post-traumatic osteoarthritis.
Satkunananthan PB, et al.
Osteoarthritis and Cartilage, 22, 1461-1461 (2014)
Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy.
Hua Y, et al.
Hypertension, 61, 1184-1184 (2013)
Cathepsin K knockout alleviates aging-induced cardiac dysfunction.
Hua Y, et al.
Aging Cell, 14, 345-345 (2015)

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