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SRP6572

Sigma-Aldrich

BRM (1367-1511) GST tag human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(s):
SMARCA2A/B, SWI/SNF ATPase
NACRES:
NA.32

origen biológico

human

recombinante

expressed in E. coli

ensayo

≥95% (SDS-PAGE)

formulario

liquid

mol peso

43.7 kDa (1367-1511 aa + NT GST Tag)

envase

pkg of 100 μg
pkg of 20 μg

Nº de acceso UniProt

enviado en

dry ice

temp. de almacenamiento

−70°C

Gene Information

human ... SMARCA2(6595)

Descripción general

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRM is a member of the SWI/SNF protein family, which forms part of a large ATP-dependent chromatin remodeling complex. This complex is required for transcriptional activation of genes normally repressed by chromatin.

Forma física

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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