T1001

Sigma-Aldrich

Thyroglobulin from bovine thyroid

powder, ≥90% (agarose gel electrophoresis)

Número de CAS:
EC Number:
MDL number:
NACRES:
NA.61
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biological source

bovine thyroid

assay

≥90% (agarose gel electrophoresis)

form

powder

mol wt

~670 kDa

composition

Iodine, ≥0.20%

nitrogen analysis

13.0-16.0% total

ash

≤4%

solubility

H2O: 20 mg/mL

storage temp.

−20°C

Gene Information

cow ... TG(280706)

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Packaging

100, 500 mg in poly bottle
1, 5 g in poly bottle

Application

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Biochem/physiol Actions

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

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Molecular & cellular proteomics : MCP, 8(4), 846-856 (2008-12-17)
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Artículos
With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.
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