T1001

Thyroglobulin from bovine thyroid

powder, ≥90% (agarose gel electrophoresis)

• Synonym(s): Globulins thyro, Thyractin
• CAS Number: 9010-34-8
• Número de EC: 232-721-3
• Número MDL: MFCD00132429
• NACRES: NA.61

Properties

• Nivel de calidad: 200
• origen biológico: bovine thyroid
• ensayo: ≥90% (agarose gel electrophoresis)
• formulario: powder
• mol peso: ~670 kDa
• composición: Iodine, ≥0.20%
• análisis de nitrógeno: 13.0-16.0% total
• ceniza: ≤4%
• solubilidad: H₂O: 20 mg/mL
• Nº de acceso UniProt: P01267
• temp. de almacenamiento: −20°C
• Gene Information: cow ... TG(280706)

Description

Envase

100, 500 mg in poly bottle

1, 5 g in poly bottle

Aplicación

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.

Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Acciones bioquímicas o fisiológicas

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.

Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Safety Information

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)