T1126

Sigma-Aldrich

Thyroglobulin from porcine thyroid gland

powder

Número de CAS:
EC Number:
MDL number:
NACRES:
NA.61
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Quality Level

biological source

Porcine thyroid

form

powder

mol wt

~670 kDa

composition

Iodine, ≥0.3%

nitrogen analysis

14.0-17.5% total

application(s)

protein purification: suitable

ash

≤4%

pI 

4.58

storage temp.

−20°C

Gene Information

pig ... TG(100156471)

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Packaging

100, 500 mg in poly bottle
1 g in poly bottle

Biochem/physiol Actions

Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.

Other Notes

Electrophoretically heterogeneous.

Preparation Note

When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
Sanathana Konugolu Venkata Sekar et al.
Scientific reports, 8(1), 10015-10015 (2018-07-04)
Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin-key tissue constituents...
L D Kohn et al.
Trends in endocrinology and metabolism: TEM, 12(1), 10-16 (2001-01-04)
Iodide transport by thyrocytes involves porters on the apical and basal surfaces of the cell facing the follicular lumen and bloodstream, respectively. Recent work identifies pendrin as an apical porter and shows that follicular thyroglobulin is a transcriptional regulator of...
Elgin Ozkan et al.
Clinical nuclear medicine, 38(5), 326-331 (2013-03-15)
This study aimed to investigate the correlation of 18F-FDG PET/CT findings with histopathological results in defining the recurrence of the disease in patients with differentiated thyroid cancer (DTC) who have increased thyroglobuline (Tg) or anti-Tg antibody (TgAb) levels and negative...
P Caturegli et al.
Autoimmunity reviews, 13(4-5), 391-397 (2014-01-18)
Hashimoto thyroiditis (HT), now considered the most common autoimmune disease, was described over a century ago as a pronounced lymphoid goiter affecting predominantly women. In addition to this classic form, several other clinico-pathologic entities are now included under the term...
Stine L Andersen et al.
European journal of endocrinology, 168(5), 723-731 (2013-02-28)
Placental transport of iodide is required for fetal thyroid hormone production. The sodium iodide symporter (NIS) mediates active iodide transport into the thyroid and the lactating mammary gland and is also present in placenta. NIS is competitively inhibited by thiocyanate...
Artículos
With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.
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