Tubocurarine hydrochloride pentahydrate


(+)-Tubocurarine hydrochloride
Empirical Formula (Hill Notation):
C37H41ClN2O6 · HCl · 5H2O
Número de CAS:
Peso molecular:
MDL number:
PubChem Substance ID:
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H2O: soluble 50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow
ethanol: soluble
methanol: soluble

storage temp.


SMILES string




InChI key


Gene Information

human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

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Tubocurarine hydrochloride pentahydrate has been used as a acetylcholinesterase inhibitor (Ach) inhibitor in myotubes, muscle and as neuromuscular junction blocker in zebra fish embryos.

Biochem/physiol Actions

Tubocurarine is a muscle relaxant and a nicotinic acetylcholine receptor antagonist. It can induce neuromuscular blocking.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tubocurarine hydrochloride pentahydrate is soluble in water at 50 mg/ml (with heat as required) and yields a clear to slightly hazy, colorless to yellow solution. It is also soluble in methanol and ethanol.


Skull and crossbones




Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes


Risk Statement


Safety Statement



UN 1544PSN2 6.1 / PGII

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

A Ashkenazi et al.
Journal of the neurological sciences, 164(2), 124-128 (1999-07-13)
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K Sato et al.
British journal of anaesthesia, 82(6), 904-909 (1999-11-24)
We have studied the effect of non-depolarizing neuromuscular blocking agents, at concentrations present in serum during anaesthesia, on release of [3H]-norepinephrine ([3H]NE) from superfused atrial appendage obtained during cardiac surgery from 48 patients. Three of the neuromuscular blocking agents (pancuronium...
M F Usiak et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(18), 7925-7939 (1999-09-10)
To understand better how spontaneous motoneuron activity and intramuscular nerve branching influence motoneuron survival, we chronically treated chicken embryos in ovo with either d-tubocurarine (dTC) or muscimol during the naturally occurring cell death period, assessing their effects on activity by...
Natural bizbenzoquinoline derivatives protect zebrafish lateral line sensory hair cells from aminoglycoside toxicity
Kruger M, et al.
Frontiers in Cellular Neuroscience, 10, 83-83 (2016)
Alejandro M Gomez et al.
Journal of immunology (Baltimore, Md. : 1950), 186(4), 2503-2513 (2011-01-18)
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