T3309

Sigma-Aldrich

Transferrin human

≥98%

Sinónimos:
Siderophilin, partially saturated
Número de CAS:
EC Number:
MDL number:
NACRES:
NA.61
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Quality Level

biological source

human

assay

≥98%

form

powder

Iron content

300-600 ppm

application(s)

cell culture | stem cell: suitable

impurities

≤1.0 EU/mg endotoxin

storage temp.

2-8°C

Gene Information

human ... TF(7018)

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General description

Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

Application

Transferrin has been used:
  • in isolation of epidermal stem cells and cell expansion
  • to study the effect of compound treatment on transferrin uptake
  • for transferrin uptake and confocal imaging

Biochem/physiol Actions

Transferrin facilitates the transfer of iron to erythron and peripheral tissues. Mutations in this gene is associated with atransferrinemia. Transferrin is required for fetal development. It is non immunogenic and transferrin-conjugated drugs inhibits cardiotoxicity and drug resistance.
Transferrin was shown to promote the proliferation of human lymphocytes. This effect is directly proportional to the level of iron present.

Analysis Note

Purity by agarose electrophoresis.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the carbohydrate content of human transferrin?

    We have found the information on transferrin in a reference book:The Plasma Proteins, F.W. Putnam, ed, volume 2, chapter 4, Table II.According to the table, Transferrin is 6 percent carbohydrate, citing G.A. Jamieson, J. Biol. Chem. 240(7), 2914-2920 (1965).The table also gives information on the percentage of each type of monosaccharide that is present.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Large scale screening and identification of novel Ebolavirus and Marburgvirus entry inhibitors
Anantpadma M, et al.
Antimicrobial Agents and Chemotherapy, AAC-00543 (2016)
Bioengineering strategies for designing targeted cancer therapies
Alexander-Bryant AA, et al.
Advances in Cancer Research, 118(11), 1-59 (2013)
Increasing serum transferrin to reduce tissue iron overload due to ineffective erythropoiesis
Tolosano E
The Hematology Journal : The Official Journal of the European Haematology Association / EHA (2015)
Nutritional issues in the patient with diabetes and foot ulcers
LITCHFORD MD
Levin and O'Neal's The Diabetic Foot, 199-217 (2008)
Influence of tobacco smoking on transferrin sialylation during pregnancy in smoking and non-smoking women with iron deficiency
Wrzesniak M, et al.
Environmental Toxicology and Pharmacology, 46, 95-102 (2016)

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