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T3830

Sigma-Aldrich

Triciribine hydrate

≥97% (HPLC)

Synonym(s):
API-2, Akt/PKB Signaling Inhibitor-2, NSC 154020, VD-0002, Inhibitor V, TCN
Empirical Formula (Hill Notation):
C13H16N6O4 · xH2O
CAS Number:
Molecular Weight:
320.30 (anhydrous basis)
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥97% (HPLC)

formulario

powder

color

tan

solubilidad

DMSO: >10 mg/mL

temp. de almacenamiento

2-8°C

SMILES string

O.Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c4ncnc1c24

InChI

1S/C13H16N6O4.H2O/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13;/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17);1H2/t6-,8-,9-,13-;/m1./s1

InChI key

SPGRLWCWHWRPHX-DOKXERMVSA-N

Gene Information

human ... AKT1(207)
mouse ... AKT1(11651)
rat ... AKT1(24185)

Envase

5, 25 mg in glass bottle

Aplicación

Triciribine hydrate has been used to study the effect of diethyldithiocarbamate (DDC) on matrix metalloproteinase-1 (MMP-1) in hepatic stellate cells1. It has also been used to analyze ADAM 10 activation by (-)-epigallocatechin-3-gallate (EGCG) in N2a cells overexpressing Swedish mutant APP (SweAPP N2a cells)2.

Acciones bioquímicas o fisiológicas

Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.

Características y beneficios

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

Triciribine hydrate is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificate of Analysis

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Certificate of Origin

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