T4687

Sigma-Aldrich

Thimerosal

meets USP testing specifications

Sinónimos:
2-(Ethylmercuriomercapto)benzoic acid sodium salt, Mercury-(o-carboxyphenylthio)ethyl sodium salt, Ethylmercurithiosalicylic acid sodium salt, Sodium ethylmercurithiosalicylate
Fórmula lineal:
2-(C2H5HgS)C6H4CO2Na
Número de CAS:
Peso molecular:
404.81
Beilstein/REAXYS Number:
8169555
EC Number:
MDL number:
PubChem Substance ID:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

biological source

synthetic (Organic)

Agency/Method

USP/NF
meets USP testing specifications

form

powder

mp

234-237 °C (dec.) (lit.)

cation traces

Hg: ≤0.70% (ions)

Mode of action

enzyme | inhibits

SMILES string

Na+.CCHgSc1ccccc1C(O-)=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

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Packaging

10, 25 g in glass bottle

Biochem/physiol Actions

Thimerosal is a sulfhydryl (thiol) oxidizing reagent capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins such as PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na++K+ dependent ATPases.

Other Notes

As part of the corporation global plan to support the Minamata Convention eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. Sales of thimerosal will be restricted for approved applications only.
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

signalword

Danger

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

T+,N

Risk Statement

26/27/28-33-50/53

Safety Statement

13-28-36-45-60-61

RIDADR

UN 2025 6.1 / PGIII

WGK Germany

WGK 3

Flash Point F

482.0 °F - closed cup

Flash Point C

250 °C - closed cup

Alicia Bazzano et al.
American journal on intellectual and developmental disabilities, 117(3), 233-242 (2012-06-22)
Although the assertion of a link between vaccines and autism has been scientifically rejected, the theory continues to be popular and may influence the attitudes of parents of children with autism spectrum disorders. The authors sought to assess how often...
H Möller
Contact dermatitis, 31(4), 209-213 (1994-10-01)
By and large, positive patch tests with thimerosal lack clinical relevance and should cause concern neither to the dermatologist nor to the patient. The substance should be retained in standard test series for scientific purposes, but on clinical grounds its...
Deniz Yeter et al.
Autoimmunity reviews, 11(12), 903-908 (2012-04-14)
Recently, a single nucleotide polymorphism (SNP) of the inositol 1,4,5-triphosphate kinase C (ITPKC), rs28493229, was found to passively confer susceptibility for Kawasaki syndrome (KS) and subsequent coronary arterial lesions. This association is believed to be the result of defective phosphorylation...
José G Dórea et al.
Journal of applied toxicology : JAT, 33(8), 700-711 (2013-02-13)
Ethylmercury (etHg) is derived from the metabolism of thimerosal (o-carboxyphenyl-thio-ethyl-sodium salt), which is the most widely used form of organic mercury. Because of its application as a vaccine preservative, almost every human and animal (domestic and farmed) that has been...
Pan-Chyr Yang et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 111(6), 333-339 (2012-07-04)
This study evaluated the immune response elicited by two formulations of an AS03(A)-adjuvanted H5N1 A/Indonesia/05/2005 prepandemic influenza vaccine, developed using manufacturing processes with or without thiomersal. In addition, it also evaluated compliance to the Centre for Biologics Evaluation and Research...

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