Triosephosphate Isomerase from rabbit muscle

Type X, lyophilized powder, ≥3,500 units/mg protein

TPI, D-Glyceraldehyde-3-phosphate ketol-isomerase
Número de CAS:
Comisión internacional de enzimas:
EC Number:
MDL number:
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level


Type X


lyophilized powder

specific activity

≥3,500 units/mg protein

mol wt

calculated mol wt 53.2 kDa


Protein, 60-90% biuret

foreign activity

pyruvate kinase, lactic dehydrogenase, 3-phosphoglyceric phosphokinase, phosphoglucose isomerase, α-glycerophosphate dehydrogenase, aldolase and glyceraldehyde-3-phosphate dehydrogenase ≤0.01%

storage temp.


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General description

Triosephosphate isomerase (TPI) gene is located on human chromosome 12p13. It is expressed in all tissues. This homodimer of two 27 kDa subunits is highly stable and is made up of 248 amino acids. TPI is catalytically active in its dimeric state.


Triosephosphate isomerase has been used in a study to assess changes in cardiac energy metabolic pathways in overweight rats fed a high-fat diet. Triosephosphate isomerase has also been used in a study to investigate proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure.
Triosephosphate Isomerase from rabbit muscle has been complexed with p-hydroxymercurybenzoate (PHMB) to denature the protein for hydrophobic interaction chromatography coupled online with chemical vapour atomic fluorescence spectrometry (HIC−CVGAFS).


1, 5 mg in serum bottle
Package size based on protein content

Biochem/physiol Actions

Triosephosphate isomerase (TPI) is responsible for the catalysis of the triose phosphate isomers, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. TPI deficiency is associated with glycolytic enzymopathy. Lack of TPI is also associated with chronic hemolytic anemia, enhanced exposure to bacterial infections, cardiomyopathy and neuromuscular disease.

Unit Definition

One unit will convert 1.0 μmole D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate per min at pH 7.6 at 25 °C.

Physical form

Sulfate-free, contains EDTA and borate buffer salts

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Hydrophobic interaction chromatography coupled with atomic fluorescence spectrometric detection: Effect of the denaturation on the determination of thiolic proteins
Bramanti E, et al.
Talanta, 63(2), 383-389 (2004)
Red blood cell enzymopathies
Hematology, 616-625 (2018)
Changes in cardiac energy metabolic pathways in overweighed rats fed a high-fat diet
Modrego, J., et al.
European Journal of Nutrition, DOI: 10-DOI: 10 (2012)
Zhenlie Huang et al.
Toxicology and applied pharmacology, 263(1), 44-52 (2012-06-12)
1-Bromopropane (1-BP) is neurotoxic in both experimental animals and humans. Previous proteomic analysis of rat hippocampus implicated alteration of protein expression in oxidative stress, suggesting that oxidative stress plays a role in 1-BP-induced neurotoxicity. To understand this role at the...
Triosephosphate isomerase deficiency: new insights into an enigmatic disease
Orosz F, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1792(12), 1168-1174 (2009)

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