Merck
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T6638

Sigma-Aldrich

Tolnaftate

Synonym(s):
Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester
Empirical Formula (Hill Notation):
C19H17NOS
CAS Number:
Molecular Weight:
307.41
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.85

formulario

powder

Nivel de calidad

200

condiciones de almacenamiento

(Keep container tightly closed in a dry and well-ventilated place.)

color

white to off-white

solubilidad

chloroform: soluble 50 mg/mL

espectro de actividad antibiótica

fungi

Modo de acción

enzyme | inhibits

temp. de almacenamiento

2-8°C

SMILES string

CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3

InChI

1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3

InChI key

FUSNMLFNXJSCDI-UHFFFAOYSA-N

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Aplicación

Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies.

Acciones bioquímicas o fisiológicas

Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.

Envase

1G,5G

Otras notas

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T6638.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Keep container tightly closed in a dry and well-ventilated place.

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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Product Information Sheet

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