T7329

Taurolidine

>97% (NMR), powder

• Sinónimos: Tauroline, 4,4′-Methylenebis(tetrahydro-1,2,4-sulfadiazine 1,1-dioxide), Taurolin
• Empirical Formula (Hill Notation): C₇H₁₆N₄O₄S₂
• Número de CAS: 19388-87-5
• Peso molecular: 284.36
• EC Number: 243-016-5
• MDL number: MFCD00865076
• PubChem Substance ID: 329826864
• NACRES: NA.77

Propiedades

• assay: >97% (NMR)
• form: powder
• storage condition: protect from light
• color: white to off-white
• solubility: DMSO: >20 mg/mL
• storage temp.: room temp
• SMILES string: O=S1(=O)CCN(CN1)CN2CCS(=O)(=O)NC2
• InChI: 1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2
• InChI key: AJKIRUJIDFJUKJ-UHFFFAOYSA-N

Descripción

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Taurolidine is a broad spectrum antibiotic with antineoplastic activity, which induces apoptosis and decreases tumor cell proliferation. Taurolidine has been used with TNF-related-apoptosis-inducing ligand (TRAIL) to characterize synergistic responses in many apoptosis related signaling-proteins. Tauroline is also being used as a tool to study the various mechanisms of apoptosis and necrosis.

Taurolidine is an antibacterial agent that can be used for the treatment of peritonis. It has also been used as an antiendoxic substance for systematic inflammatory response syndrome and as an anti-angiogenic agent for tumors. Furthermore, studies have reported that taurolidine can be used for the prevention of multiple catheter-related bloodstream infections.

Preparation Note

Taurolidine is soluble in DMSO at a concentration that is greater than 20 mg/ml.

Información de seguridad

• RIDADR: NONH for all modes of transport
• WGK Germany: WGK 3
• Flash Point F: Not applicable
• Flash Point C: Not applicable