Monoclonal Anti-β-Tubulin I+II antibody produced in mouse

clone JDR.3B8, ascites fluid

MDL number:

Quality Level

biological source


antibody form

ascites fluid

antibody product type

primary antibodies


JDR.3B8, monoclonal


15 mM sodium azide

species reactivity

human, chicken, mouse, rat, bovine, pig


antibody small pack of 25 μL


indirect ELISA: suitable
indirect immunofluorescence: suitable
microarray: suitable
western blot: 1:1,000 using a chicken fibroblast extract or a chicken brain microtubule proteins preparation





UniProt accession no.

shipped in

dry ice

storage temp.


Categorías relacionadas

General description

β-tubulin belongs to the subfamily of tubulins, which are the major building blocks of microtubules. β-tubulin has a molecular weight of 55kDa. β-tubulin structure is characterized with a core of two β-sheets enclosed by α-helices. In addition, it also contains an N-terminal domain with the guanine nucleotide-binding region, an intermediate domain with taxol-binding site and a C-terminal domain that contains the binding surface for molecular motor proteins. β-tubulin I and II is encoded by the gene mapped to human chromosome 20 and 6p25.2 respectively.
Monoclonal Anti-β-Tubulin Isotype I + II (mouse IgG2b isotype) is derived from the JDR.3B8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice.


The antibody specifically recognizes an epitope located on isotypes I and II of β-tubulin. No cross-reactivity with other tubulin isotypes is observed.


synthetic peptide corresponding to the C-terminal sequence of human β-tubulin isotype II coupled to BSA


Monoclonal Anti-β-Tubulin I+II antibody produced in mouse has been used in following studies:
  • immunoblot
  • immunofluorescence technique
  • immunohistochemistry.
Monoclonal Anti-β-Tubulin I+II antibody produced in mouse has been used in:
  • enzyme linked immunosorbent assay (ELISA)
  • immunohistochemistry
  • western blotting
  • immunoblotting
  • dot blot
  • immunocytochemistry

Biochem/physiol Actions

β-1 tubulin, also known as class VI or TUBB1, plays a vital role in platelet production and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP). Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations. B2702 peptide binds to β-tubulin and inhibits natural killer (NK) cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton organization and chaperone-like activity of tubulin. Tubulin β 2B class IIb (TUBB2B)/β-tubulin II plays a vital role in migration/organization and axon guidance processes. Mutation in β-tubulin gene is associated with the development of asymmetric polymicrogyria (PMG).


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


12 - Non Combustible Liquids

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis

Certificado de origen

Cytoskeleton in action: Lissencephaly, a neuronal migration disorder
Moon HM
Wiley interdisciplinary reviews. Developmental biology, 2, 229-245 (2013)
Jeffrey K Huang et al.
BMC developmental biology, 7, 59-59 (2007-06-02)
Trigeminal nerves consist of ophthalmic, maxillary, and mandibular branches that project to distinct regions of the facial epidermis. In Xenopus embryos, the mandibular branch of the trigeminal nerve extends toward and innervates the cement gland in the anterior facial epithelium....
A novel mutation in the β-tubulin gene TUBB2B associated with complex malformation of cortical development and deficits in axonal guidance.
Romaniello R
Developmental Medicine and Child Neurology, 54, 765-769 (2012)
Prostate cancer sheds the alphabeta3 integrin in vivo through exosomes
Krishn SR, et al.
Matrix Biology, 77, 41-57 (2019)
Symmetric polymicrogyria and pachygyria associated with TUBB2B gene mutations.
Guerrini R
European Journal of Human Genetics, 20, 995-998 (2012)
Microtubules of the eukaryotic cytoskeleton are composed of a heterodimer of α- and β-tubulin. In addition to α-and β-tubulin, several other tubulins have been identified, bringing the number of distinct tubulin classes to seven.
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