T9145

Sigma-Aldrich

Thyroglobulin from bovine thyroid

(For Gel Filtration Chromatography)

Número de CAS:
EC Number:
MDL number:
NACRES:
NA.56
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

biological source

bovine thyroid

form

powder

mol wt

~670 kDa

application(s)

bioconjugation: suitable

storage temp.

−20°C

Gene Information

cow ... TG(280706)

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Application

Thyroglobulin is used for antibody purification and characterization. Thyroglobulin has been used in studies assessing the monitoring of differentiated thyroid cancer as well as to develop an accurate diagnostic tool for patients with autoimmune thyroid diseases.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Biochem/physiol Actions

Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Andrew N Hoofnagle et al.
Clinical chemistry, 54(11), 1796-1804 (2008-09-20)
Quantification of serum tumor markers plays an important role in determining whether patients treated for cancer require further therapy. Whereas large-scale proteomic efforts aim to identify novel tumor markers to facilitate early detection, optimization of methods for quantifying known tumor...
Perrine Munier et al.
Annales de biologie clinique, 69(6), 721-725 (2011-11-30)
Thyroglobuline (Tg) is a large molecule of high molecular weight mainly indicated in monitoring differentiated thyroid cancer (DTC), its measurement remains difficult. We report the case of a patient who underwent total thyroidectomy for a poorly differentiated thyroid insular carcinoma....
Akio Yoshida et al.
The Journal of clinical endocrinology and metabolism, 94(2), 442-448 (2008-12-04)
Pendrin is an apical protein of thyroid follicular cells, responsible for the efflux of iodide into the follicular lumen via an iodide-chloride transport mechanism. It is unknown whether pendrin is recognized by autoantibodies. Our objective was to examine the prevalence...
Claire D McWhite et al.
Cell, 181(2), 460-474 (2020-03-20)
Plants are foundational for global ecological and economic systems, but most plant proteins remain uncharacterized. Protein interaction networks often suggest protein functions and open new avenues to characterize genes and proteins. We therefore systematically determined protein complexes from 13 plant...
F Latrofa et al.
Clinical and experimental immunology, 178(3), 438-446 (2014-08-20)
The subclass distribution of thyroglobulin autoantibodies (TgAb) is debated, whereas their epitope pattern is restricted. Radioidine ((131)I) treatment for Graves' disease (GD) induces a rise in TgAb levels, but it is unknown whether it modifies subclass distribution and epitope pattern...
Artículos
With the emergence of mass spectrometry for the clinical measurement of proteins in biological matrices, the development of biological reference materials will continue to grow in importance.
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