U3885

Sigma-Aldrich

UK-78282 monohydrochloride

≥98% (HPLC)

Sinónimos:
4-(Diphenylmethoxy)methyl-1-3-(4-methoxyphenyl)propyl-piperidine monohydrochloride
Empirical Formula (Hill Notation):
C29H35NO2HCl
Número de CAS:
Peso molecular:
466.05
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL

originator

Pfizer

shipped in

wet ice

storage temp.

−20°C

SMILES string

Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1

InChI

1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H

InChI key

ZZSQARULZYQMIG-UHFFFAOYSA-N

Categorías relacionadas

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml.

pictograms

Exclamation markEnvironment

signalword

Warning

hcodes

Hazard Codes

Xi,N

Risk Statement

36-50/53

Safety Statement

26-60-61

RIDADR

UN 3077 9 / PGIII

WGK Germany

3

Artículos
We offer many products related to potassium channels for your research needs.
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