UC175

Sigma-Aldrich

(S)-(+)-Mephenytoin

solid, ≥98% (HPLC)

Sinónimos:
(S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione, (S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin
Empirical Formula (Hill Notation):
C12H14N2O2
Número de CAS:
Peso molecular:
218.25
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

form

solid

color

off-white

mp

135-138 °C

solubility

DMSO: soluble

storage temp.

2-8°C

SMILES string

CC[C@]1(NC(=O)N(C)C1=O)c2ccccc2

InChI

1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)/t12-/m0/s1

InChI key

GMHKMTDVRCWUDX-LBPRGKRZSA-N

Application

S-Mephenytoin has been used as a CYP2C19 substrate for the analysis of cytochrome P450 metabolism. S-Mephenytoin has also been used as probe substrates for LC/MS-based analysis of relative activity factor (RAF).

Packaging

5, 10 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

CYP2B6 & CYP2C19 substrate. Methenytoin isomer. Anticonvulsant; antiepileptic.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

(S)-(+)-Mephenytoin is soluble in DMSO.

pictograms

Exclamation mark

signalword

Warning

Target Organs

Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point F

Not applicable

Flash Point C

Not applicable

Brandon S Pybus et al.
Malaria journal, 11, 259-259 (2012-08-04)
The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale as well as Stage V gametocytes of Plasmodium falciparum. To date, several...
Bent H Hellum et al.
Basic & clinical pharmacology & toxicology, 105(1), 58-63 (2009-04-18)
The aim of this study was to evaluate in vitro the dose-dependent induction potential of six commonly used trade herbal products on CYP2C19 and CYP2E1 metabolic activities in cultured human hepatocytes. S-mephenytoin and chlorzoxazone were used as specific CYP substrates...
Stefan J Dekker et al.
British journal of pharmacology, 176(3), 466-477 (2018-11-18)
The aim of this study was to characterize the human cytochrome P450s (CYPs) involved in oxidative bioactivation of flucloxacillin to 5-hydroxymethyl flucloxacillin, a metabolite with high cytotoxicity towards biliary epithelial cells. The CYPs involved in hydroxylation of flucloxacillin were characterized...
Contenido relacionado
Discover Bioactive Small Molecules for ADME/Tox
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