V0130

Sigma-Aldrich

[Arg8]-Vasotocin acetate salt

≥97% (HPLC)

Empirical Formula (Hill Notation):
C43H67N15O12S2
Número de CAS:
Peso molecular:
1050.22
MDL number:
PubChem Substance ID:
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥97% (HPLC)

solubility

H2O: soluble 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

CC[C@@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O

InChI

1S/C43H67N15O12S2/c1-3-21(2)34-41(69)53-26(12-13-31(45)60)37(65)55-28(17-32(46)61)38(66)56-29(20-72-71-19-24(44)35(63)54-27(39(67)57-34)16-22-8-10-23(59)11-9-22)42(70)58-15-5-7-30(58)40(68)52-25(6-4-14-50-43(48)49)36(64)51-18-33(47)62/h8-11,21,24-30,34,59H,3-7,12-20,44H2,1-2H3,(H2,45,60)(H2,46,61)(H2,47,62)(H,51,64)(H,52,68)(H,53,69)(H,54,63)(H,55,65)(H,56,66)(H,57,67)(H4,48,49,50)/t21-,24+,25+,26+,27+,28+,29+,30+,34+/m1/s1

InChI key

OXDZADMCOWPSOC-QLWWDPKZSA-N

Gene Information

human ... AVP(551)

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

Application

[Arg8]-Vasotocin acetate salt was used as a test compound for studying whether it can regulate the interspecific cooperative behaviour in fish. The product was used for inducing parturition in viviparous females to study reproduction in oviparous and viviparous lizard females of species Zootoca vivipara.

Biochem/physiol Actions

[Arg8]-Vasotocin (AVT) is a neurohypophyseal peptide of the vasopressin/oxytocin hormone family that mediates social behaviors, coregulates the adrenocortical stress response as well as maintains water balance. AVT stimulates neurones in the mammalian central nervous system.

Preparation Note

[Arg8]-Vasotocin acetate salt dissolves in water at 20 mg/ml to yield a clear, colorless solution.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Certificado de Análisis
H Bobby Fokidis et al.
Brain, behavior and evolution, 79(2), 84-97 (2011-11-10)
The neuropeptide arginine vasotocin (AVT: the avian homolog of vasopressin) has numerous functional roles including mediating social behaviors, coregulating the adrenocortical stress response and maintaining water balance. These functions of AVT make it susceptible to environmental influence, yet little is...
J Bleu et al.
Journal of evolutionary biology, 25(7), 1264-1274 (2012-04-28)
Reproduction entails costs, and disentangling the relative importance of each stage of the reproductive cycle may be important to assess the costs and benefits of different reproductive strategies. We studied the early costs of reproduction in oviparous and viviparous lizard...
C D Ingram et al.
Journal of neuroendocrinology, 6(4), 415-422 (1994-08-01)
Using extracellular recordings from brainstem slices in vitro, it was demonstrated that a high proportion (38/56) of neurones in the dorsal vagal complex of dioestrus, virgin female rats exhibit an excitatory response to [Arg8]-vasotocin (AVT). Pharmacological characterization suggests that these...
R Mihai et al.
Neuroscience, 62(3), 783-792 (1994-10-01)
The excitatory effect of [Arg8]-vasopressin and its potential contribution to the circadian cycle of electrical activity in the suprachiasmatic nucleus of the rat was investigated using extracellular recordings from hypothalamic slices from virgin female rats. The majority of neurons tested...
D J Conklin et al.
General and comparative endocrinology, 114(1), 36-46 (1999-03-30)
Arginine vasotocin (AVT) is present in the neurohypophysis of all nonmammalian vertebrates and it appears to be the antecedent of the neurohypophysial nonapeptide hormones. Relatively little is known about AVT receptors in lower vertebrates, especially fish, and the present study...

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