Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.
Z-VAD-FMK has been used:
to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
to induce autophagy in Jurkat and K562 cells
to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53
Acciones bioquímicas o fisiológicas
Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.
Características y beneficios
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Bottomless glass bottle. Contents are inside inserted fused cone.
Código de clase de almacenamiento
13 - Non Combustible Solids
Punto de inflamabilidad F
Punto de inflamabilidad C
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificate of Analysis
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Certificate of Origin
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