Merck
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V116

Sigma-Aldrich

Z-VAD-FMK

solid

Synonym(s):
N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
Empirical Formula (Hill Notation):
C22H30FN3O7
CAS Number:
Molecular Weight:
467.49
Número MDL:
NACRES:
NA.77

origen biológico

synthetic

Nivel de calidad

200

ensayo

≥98% (TLC)

formulario

solid

color

white

solubilidad

DMSO: 20 mg/mL
H2O: insoluble

temp. de almacenamiento

−20°C

Gene Information

human ... CASP3(836)
mouse ... CASP3(12367)
rat ... CASP3(25402)

Descripción general

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.

Aplicación

Z-VAD-FMK has been used:
  • to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
  • to induce autophagy in Jurkat and K562 cells
  • to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
  • as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53

Acciones bioquímicas o fisiológicas

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Características y beneficios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Precaución

Hygroscopic

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificate of Analysis

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Certificate of Origin

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