VEGF Receptor-3 (Flt-4)/Fc chimera human is a disulfide-linked homodimeric protein that consists of VEGF Receptor-3 fused with6X histidine tagged Fc portion of human IgG1 by a polypeptide linker. It may be used as a specific marker for lymphatic vessels as well as plays a pivotal role in the development of the lymphatic vessel system.
VEGF Receptor-3 (Flt-4) belongs to class III subfamily of RTKs and is expressed mainly in endothelial cells. VEGF Receptor-3 blocks VEGF-C/D and hence inhibits lymphangiogenesis and lymphatic metastasis in orthotopic urinary bladder cancer (OUBC).
Lyophilized from a 2 μm filtered solution in phosphate buffered saline.
The binding affinity of recombinant VEGF R3 has not been determined. Its intended use is for western blot and ELISA standards.