Documentos
V4640
VU0357017 monohydrochloride
≥98% (HPLC)
Sinónimos:
CID 25010775, ML071 hydrochloride, 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride, SID 56353039
Empirical Formula (Hill Notation):
C18H27N3O3 · HCl
Número de CAS:
Peso molecular:
369.89
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
SMILES string
Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c2ccccc2C
InChI
1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H
InChI key
XKJQVUIXSBOCPP-UHFFFAOYSA-N
Packaging
5, 25 mg in glass bottle
Biochem/physiol Actions
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Hazard Codes
N
Risk Statement
52/53
Safety Statement
61
RIDADR
NONH for all modes of transport
WGK Germany
WGK 2
Flash Point F
Not applicable
Flash Point C
Not applicable
Certificado de Análisis
Certificado de origen
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Artículos
Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.
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