≥90% (HPLC), powder

3-Veratroylveracevine, Veracevine veratrate
Empirical Formula (Hill Notation):
Número de CAS:
Peso molecular:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:
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Quality Level


≥90% (HPLC)




white to off-white


ethanol: 50 mg/mL

storage temp.


SMILES string




InChI key


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General description

Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid.


Veratridine has been used:
  • to record the veratridine-dependent increase in the late Na+ current using a HEK293 cell line stably transfected with human Na v1.5 24(4) to measure the ranolazine-induced inhibition of basal and veratridine-activated I Na late
  • to assess the effects of veratridine on action potentials (APs) in hiPSC-cardiomyocyte preparations externally paced in current-clamp mode
  • to study the inhibitory effects of veratridine on hERG1 current in stably transfected HEK293 cells
  • to treat neuroblastoma 2-a cells to improve sensitivity for N2a assay


25, 100 mg in glass bottle
10 mg in glass insert

Biochem/physiol Actions

Veratridine has been used as an insecticide, acting as a paralytic agent with higher toxicity to insects than to mammals.
Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.


Skull and crossbonesHealth hazard



Target Organs

Nervous system, Respiratory system

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN 1544PSN1 6.1 / PGI

WGK Germany


Flash Point F

Not applicable

Flash Point C

Not applicable

Silmara R Sousa et al.
PloS one, 12(9), e0182848-e0182848 (2017-09-08)
Spider venoms are rich sources of peptidic ion channel modulators with important therapeutical potential. We screened a panel of 60 spider venoms to find modulators of ion channels involved in pain transmission. We isolated, synthesized and pharmacologically characterized Cd1a, a...
R Maroto et al.
European journal of pharmacology, 270(4), 331-339 (1994-08-03)
Exposure of bovine chromaffin cells to 30 microM veratridine for 24 h led to 70-80% cell death as reflected by phase contrast microscopy, trypan blue exclusion, lactate dehydrogenase (LDH) release and cell catecholamine contents. Na+ deprivation, Ca2+ deletion or tetrodotoxin...
Irina Vetter et al.
Biochemical pharmacology, 83(11), 1562-1571 (2012-03-14)
The human neuroblastoma cell line SH-SY5Y is a potentially useful model for the identification and characterisation of Na(v) modulators, but little is known about the pharmacology of their endogenously expressed Na(v)s. The aim of this study was to determine the...
Dharmendra Singh Chauhan et al.
Theriogenology, 90, 210-218 (2017-02-09)
The aim of our study was to characterize the voltage gated sodium channel Na
Hagit Sason et al.
Cerebral cortex (New York, N.Y. : 1991), 27(2), 1573-1587 (2016-01-23)
d-Serine is a co-agonist of NMDA receptors (NMDARs) whose activity is potentially regulated by Asc-1 (SLC7A10), a transporter that displays high affinity for d-serine and glycine. Asc-1 operates as a facilitative transporter and as an antiporter, though the preferred direction...

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