W0641

Sigma-Aldrich

W-84 dibromide

≥98% (HPLC), solid

Sinónimos:
Hexamethylene-bis-dimethyl-(3-phthalimidopropyl)ammoniumdibromide
Empirical Formula (Hill Notation):
C32H44Br2N4O4
Número de CAS:
Peso molecular:
708.52
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: ~11 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

Br-.Br-.CN+(C)(CCCCCCN+(C)(C)CCCN1C(=O)c2ccccc2C1=O)CCCN3C(=O)c4ccccc4C3=O

InChI

1S/C32H44N4O4.2BrH/c1-35(2,23-13-19-33-29(37)25-15-7-8-16-26(25)30(33)38)21-11-5-6-12-22-36(3,4)24-14-20-34-31(39)27-17-9-10-18-28(27)32(34)40;;/h7-10,15-18H,5-6,11-14,19-24H2,1-4H3;2*1H/q+2;;/p-2

InChI key

DZRJZDQAGMZGGA-UHFFFAOYSA-L

Biochem/physiol Actions

Potent allosteric modulator of M2 muscarinic acetylcholine receptors.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Hazard Codes

Xi

Risk Statement

36/37/38

Safety Statement

26-36

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Stefanie Prilla et al.
Molecular pharmacology, 70(1), 181-193 (2006-04-28)
In general, the M2 subtype of muscarinic acetylcholine receptors has the highest sensitivity for allosteric modulators and the M5 subtype the lowest. The M2/M5 selectivity of some structurally diverse allosteric agents is known to be completely explained by M2 177Tyr...
G Bejeuhr et al.
The Journal of pharmacy and pharmacology, 46(2), 108-112 (1994-02-01)
W84 (N,N,N',N'-tetramethyl-N,N'-bis-(3-phthalimidopropyl)-N,N'-hexane- 1,6- diyl-bis-ammonium dibromide) is a potent stabilizer of antagonist binding to muscarinic receptors; however, W84 hydrolyses in aqueous buffered medium. The synthesis of the stable derivative CHIN3/6 is presented containing a 2-phenyl-quinazolinone instead of the labile phthalimide substituent....
K Mohr et al.
Pharmacology & toxicology, 70(3), 198-200 (1992-03-01)
W84 (hexamethylene-bis-[dimethyl-(phthalimidopropyl)-ammonium bromide]) is an experimental antidote against organophosphorus poisoning and has been found to affect muscarinic cholinoceptors allosterically. The attempt was made to test whether the W84-action on muscarinic cholinoceptors depends on the species. For this purpose, the effect...
C Tränkle et al.
Molecular pharmacology, 54(1), 139-145 (1998-07-11)
Muscarinic acetylcholine receptors bind allosteric modulators at a site apart from the orthosteric site used by conventional ligands. We tested in cardiac tissue whether modulator binding to ligand-occupied muscarinic M2 receptors is a preferential event that can be detected using...
A Christopoulos et al.
European journal of pharmacology, 355(1), 103-111 (1998-10-01)
Using the program Microsoft EXCEL, a spreadsheet was developed for constrained, simultaneous analysis of multiple datasets obtained from equilibrium binding experiments, according to an allosteric model of interaction. This approach was used to quantitate the interaction between the modulator (heptane-1,7-bis...

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