X2254

Sigma-Aldrich

XE-991

≥98% (HPLC)

Sinónimos:
10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
Empirical Formula (Hill Notation):
C26H20N2O
Número de CAS:
Peso molecular:
376.45
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

color

white to beige

solubility

DMSO: >20 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

2-8°C

SMILES string

O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15

InChI

1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2

InChI key

KHJFBUUFMUBONL-UHFFFAOYSA-N

Application

XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark

signalword

Warning

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

David Bartolomé-Martín et al.
Neuropharmacology, 161, 107568-107568 (2019-03-20)
Dopamine and glutamate transporters (DAT and GLT-1, respectively) share some biophysical characteristics, as both are secondary active carriers coupled to electrochemical ion gradients. In order to identify common or specific components of their respective proteomes, we performed a proximity labelling...
Oxytocin transforms firing mode of CA2 hippocampal neurons
Tirko N, et al.
Neuron, 100(3), 593-608 (2018)
Pauses in cholinergic interneuron activity are driven by excitatory input and delayed rectification, with dopamine modulation
Zhang Y, et al.
Neuron, 98(5), 918-925 (2018)
Lena Rubi et al.
Neuromolecular medicine, 15(3), 476-492 (2013-05-23)
Neuronal L-type voltage-gated calcium channels (LTCCs) are involved in several physiological functions, but increased activity of LTCCs has been linked to pathology. Due to the coupling of LTCC-mediated Ca(2+) influx to Ca(2+)-dependent conductances, such as KCa or non-specific cation channels...
Jorge Vicente-Baz et al.
The Journal of pharmacology and experimental therapeutics, 370(3), 472-479 (2019-06-27)
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat pain conditions in humans. In addition to its blocking activity on cyclooxygenase (COX) enzymes, several other targets could contribute to its analgesic activity. Here we explore the spinal antinociceptive...

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