Y0503

Y-27632 dihydrochloride

≥98% (HPLC)

• Synonym(s): (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-Pyridyl)cyclohexanecarboxamide dihydrochloride
• Empirical Formula (Hill Notation): C₁₄H₂₁N₃O · 2HCl
• CAS Number: 129830-38-2
• Molecular Weight: 320.26
• Número MDL: MFCD03490488
• ID de la sustancia en PubChem: 24277699
• NACRES: NA.77

Properties

• origen biológico: synthetic (organic)
• Nivel de calidad: 100
• ensayo: ≥98% (HPLC)
• formulario: powder
• actividad óptica: [α]/D +3.0 to +5.0°, c = 1.0 in methanol
• color: white to beige
• solubilidad: H₂O: 14 mg/mL
• temp. de almacenamiento: 2-8°C
• SMILES string: Cl.Cl.C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc2ccncc2
• InChI: 1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11-,12-;;/m1../s1
• InChI key: IDDDVXIUIXWAGJ-LJDSMOQUSA-N
• Gene Information: human ... ROCK1(6093) , ROCK2(9475)

Description

Descripción general

Y-27632 dihydrochloride is an effective bronchodilator and improves lung resistance (RL) induced by antigen and acetylcholine. Y-27632 controls neutrophil migration and lung edema and may be a potential drug for treating acute lung injury.

Aplicación

Y-27632 dihydrochloride has been used:

• as a medium supplement in pancreatic ductal adenocarcinoma organoid culture
• in the inhibition of Ras homolog gene family (Rho) kinase in mouse embryonic stem cells
• in the inhibition of Rho-associated protein kinase (ROCK) in human embryonic stem cells and human induced pluripotent stem cells (iPSCs)

Envase

1, 1, 5 mg in glass bottle

Acciones bioquímicas o fisiológicas

Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. K_i = 140 nM for p160^ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información legal

Sold under license from Mitsubishi Pharma Corporation

Safety Information

• Código de clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves