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Anti-Tyrosine Hydroxylase Antibody, clone 2/40/15 ZooMAb® Mouse Monoclonal

enhanced validationgreener alternative

recombinant, expressed in HEK 293 cells

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EC:, TH, Tyrosine 3-hydroxylase, Tyrosine 3-monooxygenase

biological source


Quality Level


expressed in HEK 293 cells



antibody form

purified antibody

antibody product type

primary antibodies


2/40/15, recombinant monoclonal

product line

ZooMAb® learn more



mol wt

calculated mol wt 55.97 kDa
observed mol wt ~57 kDa

species reactivity

human, mouse, rat

species reactivity (predicted by homology)

chicken, quail, bovine


antibody small pack of 25 μL

greener alternative product characteristics

Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation


immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable



UniProt accession no.

greener alternative category

shipped in


storage temp.


target post-translational modification


Gene Information

human ... TH(7054)

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Este artículo
biological source


biological source

rabbit (recombinant)

biological source


biological source

mouse (recombinant)









species reactivity

human, mouse, rat

species reactivity

rat, mouse

species reactivity

mouse, human

species reactivity



2/40/15, recombinant monoclonal


3M12, monoclonal, recombinant monoclonal


1D15, monoclonal, recombinant monoclonal


4G10, recombinant monoclonal

Gene Information

human ... TH(7054)

Gene Information

rat ... TH(25085)

Gene Information

human ... TLE3(7090)

Gene Information


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General description

We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry.This antibody is Preservative-free, produced without the harm or sacrifice of animals and exceptionally stable to allow for ambient shipping and storage if needed and thus aligns with "Waste Prevention", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here for more information.
ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.

Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.

Learn more about ZooMAb here.


Clone 2/40/15 is a ZooMAb mouse recombinant monoclonal antibody that specifically detects Tyrosine-3 Hydroxylase.


Purified tyrosine hydroxylase from a rat pheochromocytoma.


Anti-Tyrosine Hydroxylase, clone 2/40/15 ZooMAb, Cat. No. ZMS1033, is a recombinant Mouse monoclonal antibody that detects Tyrosine Hydroxylase and is tested for use in Immunocytochemistry, Immunohistochemistry (Paraffin), and Western Blotting.
Immunohistochemistry (Paraffin) Analysis: A 1:100 dilution from a representative lot detected Tyrosine Hydroxylase in rat brain and human brain tissue sections.

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Tyrosine Hydroxylase in PC12 cells.

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user

Target description

Tyrosine 3-monooxygenase (UniProt: P04177; also known as EC:, Tyrosine 3-hydroxylase, TH) is encoded by the Th gene (Gene ID: 25085) in rat. Tyrosine hydroxylase acts as a rate-limiting enzyme of catecholamine biosynthesis. It hydroxylates tyrosine to L-DOPA and then L- DOPA is converted to dopamine by aromatic amino acid decarboxylase. Tyrosine hydroxylase requires tetrahydrobiopterin and molecular oxygen to convert tyrosine to DOPA. Its activity is regulated by phosphorylation at four different serine residues by multiple protein kinases. The N-terminal region of tyrosine hydroxylase plays a critical role in controlling its catalytic activity. Its catalytic domain is located in the C-terminal region and binds the substrates and the cofactor. Its activity is inhibited by a feedback mechanism by catecholamines. Dopamine is shown to bind to tyrosine hydroxylase competitively with tetrahydrobiopterin and interacts with the regulatory domain. Tyrosine hydroxylase activity can be modified in the presence of nitric oxide that results in nitration of tyrosine residues. Tyrosine hydroxylase deficiency leads to impaired synthesis of dopamine as well as epinephrine and norepinephrine and significantly reduced tyrosine hydroxylase activity and dopamine levels are reported in the brain of Parkinson s disease subjects. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals. (Ref.: Daubner SC et al., (2011). Arch. Biochem. Biophys. 508(1): 1-12).

Physical form

Purified recombinant mouse monoclonal antibody IgG, lyophilized in PBS, 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.


30 μg/mL after reconstitution at 25 μL per vial. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

Storage and Stability

Recommend storage of lyophilized product at 2-8°C; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8°C, or -20°C for long term storage. Avoid repeated freeze-thaws.

Legal Information

ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

11 - Combustible Solids




Not applicable


Not applicable

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