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ZRB1218

Sigma-Aldrich

Anti-Parvalbumin Antibody, clone 4G3 , ZooMAb® Rabbit Monoclonal

enhanced validationgreener alternative

recombinant, expressed in HEK 293 cells

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Sinónimos:
PV, Parvalbumin alpha

origen biológico

rabbit (recombinant)

Nivel de calidad

recombinante

expressed in HEK 293 cells

conjugado

unconjugated

forma del anticuerpo

purified antibody

antibody product type

primary antibodies

clon

4G3, recombinant monoclonal

Línea del producto

ZooMAb® learn more

formulario

lyophilized

mol peso

calculated mol wt 12.06 kDa
observed mol wt ~12 kDa

species reactivity

human, mouse, rat

envase

antibody small pack of 25 μL

características de los productos alternativos más sostenibles

Waste Prevention
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

validación mejorada

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

isotipo

IgG

Nº de acceso UniProt

categoría alternativa más sostenible

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

target post-translational modification

unmodified

Gene Information

human ... PVALB(5816)
mouse ... Pvalb(19293)
rat ... Pvalb(25269)

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Este artículo
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recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

clone

4G3, recombinant monoclonal

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product line

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ZooMAb® learn more

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Descripción general

We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry.This antibody is Preservative-free, produced without the harm or sacrifice of animals and exceptionally stable to allow for ambient shipping and storage if needed and thus aligns with "Waste Prevention", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here for more information.
ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.

Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.

Learn more about ZooMAb here.

Especificidad

Clone 4G3 is a ZooMAb rabbit recombinant monoclonal antibody that specifically detects Parvalbumin.

Inmunógeno

GST/His-tagged full-length recombinant human Parvalbumin.

Aplicación

Anti-Parvalbumin, clone 4G3 ZooMAb, Cat. No. ZRB1218, is a highly specific rabbit recombinant monoclonal antibody that targets Parvalbumin and has been tested for use in Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blotting.
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected Parvalbumin in rat and human brain tissue lysate.

Immunohistochemistry (Paraffin) Analysis: A 1:100 dilution from a representative lot detected Parvalbumin in human cerebellum and mouse cerebellum tissue sections.

Immunofluorescence Analysis: A 1:100 dilution from a representative lot detected Parvalbumin in mouse cerebellum tissue sections.

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Parvalbumin in PC12 cells.

Note: Actual optimal working dilutions must be determined by end user as specimens and experimental conditions may vary.

Descripción de destino

Parvalbumin alpha (UniProt: P20472; also known as PV) is encoded by the PVALB gene (Gene ID: 5816) in human. Parvalbumin is a low molecular weight soluble protein that binds two calcium ions with high affinity and is implicated in intracellular calcium regulation and trafficking. It is composed almost entirely of two EF-hand domains (aa. 39-74 & 78-110) and is structurally related to calmodulin and troponin C. It serves as a slow Ca2+ buffer that affects the amplitude and time course of intracellular Ca2+ transients in terminals after an action potential, and hence may regulate short-term synaptic plasticity. During nervous system development, its expression is shown to accompany the maturation of functional circuits. Parvalbumin containing neurons are abundant in the cortex, the hippocampus, and the thalamus. It is present in GABAergic interneurons in the nervous system, especially the reticular thalamus. Parvalbumin interneurons are a subset of inhibitory GABAergic neurons that control the excitability of post-synaptic pyramidal neurons. Dysfunction or loss of parvalbumin interneurons has been implicated in cognitive deficits associated with several well-known psychiatric disorders, including schizophrenia and depression. This ZooMAb recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals.

Forma física

Purified recombinant rabbit monoclonal antibody IgG, lyophilized in PBS with 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.

Reconstitución

30 μg/mL after reconstitution at 25 μL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.

Almacenamiento y estabilidad

Recommend storage of lyophilized product at 2-8°C; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8°C, or -20°C for long term storage. Avoid repeated freeze-thaws.

Información legal

ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Thomas J Pisano et al.
Cell reports, 36(12), 109721-109721 (2021-09-23)
Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional tracing. Here, we quantify pathways between the cerebellum and forebrain by using transsynaptic tracing viruses and a whole-brain analysis pipeline. With retrograde tracing, we find that

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