Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes.
Gwinn, et al.
Toxicological Sciences, 176, 343-354 (2020)
J L Merdink et al.
Journal of applied toxicology : JAT, 21(1), 53-57 (2001-02-17)
The oral and i.v. elimination kinetics were investigated for bromodichloroacetate (BDCA), a haloacetate found in drinking water. The BDCA was administered at a dose of 5, 20 and 100 mg kg-1 to B6C3F1 mice and appears to distribute to the...
G Xu et al.
Drug metabolism and disposition: the biological fate of chemicals, 23(12), 1412-1416 (1995-12-01)
Trichloroacetate (TCA), dichloroacetate (DCA), and bromodichloroacetate (BDCA) are byproducts of the chlorination of drinking water. TCA acts primarily as a peroxisome proliferator, but DCA produces tumors at doses less than required for peroxisome proliferation. BDCA does not induce peroxisome proliferation...
V Lopez-Avila et al.
Journal of AOAC International, 82(3), 689-704 (1999-06-15)
The microextraction/ion chromatographic (IC) method developed in this study involves extraction of 9 haloacetic acids (HAAs) from aqueous samples (acidified with sulfuric acid to a pH of < 0.5 and amended with copper sulfate pentahydrate and sodium sulfate) with methyl...
E Sidney Hunter et al.
Reproductive toxicology (Elmsford, N.Y.), 21(3), 260-266 (2005-11-19)
The haloacetic acids (HAA) are a family of chemicals that are drinking water disinfection by-products. We previously reported that haloacetic acids, including several bromo- and chloro-HAAs, alter embryonic development when mouse conceptuses are directly exposed to these xenobiotics in whole...