Chemicals used in the downstream processing and purification of biologics often have multiple functions that vary by application, complicating selection for manufacturers with specific quality or cost expectations. Our broad portfolio of downstream chemicals streamlines raw material specification with optimized quality attributes for the full range of downstream needs – then goes a step further by seamlessly integrating supply transparency, documentation, good manufacturing practice (GMP), and change control, all tailored to your risk assessments.
Raw materials within our industry-leading Emprove® chemicals portfolio are supported with comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve processes. The portfolio is divided into categories that reflect the specific application needs of drug manufacturers.
Our broad range of downstream chemicals and buffers helps to guide your monoclonal antibody from upstream processing to the final fill. You will find compounds that perform a variety of functions, including mAb modification and stabilization.
Increasing yields and maintaining safety are major challenges in plasma processes. Our downstream chemicals provide the tools you need to run complex plasma-fractionation processes successfully, by maintaining process safety.
Vaccine and gene therapy manufacturers need to reach high yields, maintain product safety, and accelerate development timelines. Our proven portfolio of reliable and consistent chemicals and manufacturing enzymes such as Benzonase® endonuclease helps you cope with those challenges, supporting your vaccine and gene therapy processes from harvest throughout your entire downstream process.
Using microbial expression systems such as yeast and bacteria to manufacture simpler molecules offers reduced production cost and significantly higher upstream productivity. Our portfolio supports any step from the reactor to final product, including purification and modification.