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Weerapon Sangartit et al.
PloS one, 9(12), e114908-e114908 (2014-12-17)
Cadmium (Cd) is a nonessential heavy metal, causing oxidative damage to various tissues and associated with hypertension. Tetrahydrocurcumin (THU), a major metabolite of curcumin, has been demonstrated to be an antioxidant, anti-diabetic, anti-hypertensive and anti-inflammatory agent. In this study, we
Sarah E Greene et al.
mBio, 5(6), e02038-e02038 (2014-10-30)
Chaperone-usher pathway (CUP) pili are extracellular organelles produced by Gram-negative bacteria that mediate bacterial pathogenesis. Small-molecule inhibitors of CUP pili, termed pilicides, were rationally designed and shown to inhibit type 1 or P piliation. Here, we show that pilicide ec240
Smita Joel et al.
ACS chemical biology, 9(7), 1595-1602 (2014-05-21)
Advancements in biotechnology have allowed for the preparation of designer proteins with a wide spectrum of unprecedented chemical and physical properties. A variety of chemical and genetic methods can be employed to tailor the protein's properties, including its stability and
Zhenling Cui et al.
Journal of the American Chemical Society, 137(13), 4404-4413 (2015-03-31)
Genetic code expansion is a key objective of synthetic biology and protein engineering. Most efforts in this direction are focused on reassigning termination or decoding quadruplet codons. While the redundancy of genetic code provides a large number of potentially reassignable
Yu-Zhou Xiao et al.
Molecular medicine reports, 11(2), 1146-1152 (2014-11-06)
The use of artificial nerves for the repair of peripheral nerve defects is restricted by the limited sources of Schwann cells (SCs). Human mesenchymal stem cell (MSC)‑derived Schwann‑like cells are considered an alternative and desirable cell source. The aim of
Victor Romanov et al.
Archives of toxicology, 89(1), 47-56 (2014-05-06)
Ingestion of aristolochic acids (AAs) contained in herbal remedies results in a renal disease and, frequently, urothelial malignancy. The genotoxicity of AA in renal cells, including mutagenic DNA adducts formation, is well documented. However, the mechanisms of AA-induced tubular atrophy
Frank Y Ma et al.
American journal of physiology. Renal physiology, 307(11), F1263-F1273 (2014-10-10)
Stress-activated kinases p38 MAPK and JNK promote renal fibrosis; however, how the pathways by which these kinases are activated in kidney disease remain poorly defined. Apoptosis signal-regulating kinase 1 (ASK1/MAPKKK5) is a member of the MAPKKK family that can induce
Cliff I Oduor et al.
The American journal of tropical medicine and hygiene, 91(3), 649-654 (2014-07-30)
Overexpression of interleukin-6 (IL-6) and IL-10 in endemic Burkitt lymphoma (eBL) may facilitate tumorigenesis by providing a permissive cytokine milieu. Promoter polymorphisms influence interindividual differences in cytokine production. We hypothesized that children genetically predisposed for elevated cytokine levels may be
Jennifer D Lewis et al.
PloS one, 9(12), e116152-e116152 (2014-12-30)
Pseudomonas syringae employs a type III secretion system to inject 20-30 different type III effector (T3SE) proteins into plant host cells. A major role of T3SEs is to suppress plant immune responses and promote bacterial infection. The YopJ/HopZ acetyltransferases are
Gretchen Harms Pritchard et al.
Journal of immunology (Baltimore, Md. : 1950), 194(3), 1131-1140 (2015-01-04)
The transcription factor T-bet has been most prominently linked to NK and T cell production of IFN-γ, a cytokine required for the control of a diverse array of intracellular pathogens. Indeed, in mice challenged with the parasite Toxoplasma gondii, NK
Kim D Allen et al.
PloS one, 9(8), e104364-e104364 (2014-08-05)
Long-term memory (LTM) formation requires new protein synthesis and new gene expression. Based on our work in Aplysia, we hypothesized that the rRNA genes, stimulation-dependent targets of the enzyme Poly(ADP-ribose) polymerase-1 (PARP-1), are primary effectors of the activity-dependent changes in
Arun Sharma et al.
Circulation research, 115(6), 556-566 (2014-07-13)
Viral myocarditis is a life-threatening illness that may lead to heart failure or cardiac arrhythmias. A major causative agent for viral myocarditis is the B3 strain of coxsackievirus, a positive-sense RNA enterovirus. However, human cardiac tissues are difficult to procure
Anne-Coline Laurent et al.
Cardiovascular research, 105(1), 55-64 (2014-11-21)
Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood mechanisms. We previously demonstrated that Exchange protein directly activated by cAMP 1 (Epac1)-induced hypertrophy in primary cardiomyocytes. Among the
K Heindorff et al.
Mutation research, 115(2), 149-173 (1983-06-01)
EDTA and its salts have a number of applications in medicine and pharmacy. EDTA is used to remove calcium from the human body, and serves as an anticoagulant and as a detoxicant after poisoning by heavy metals. It is often
Y Kostova et al.
Cancer gene therapy, 22(1), 30-43 (2014-12-17)
We investigated the novel recombinant oncolytic adenovirus Ad-delo-sr39TK-RGD, armed with a mutant herpes simplex virus type 1 thymidine kinase (HSV1-sr39TK) as a suicide gene, and explored its antitumor efficacy in combination with HSV1-sr39TK/ganciclovir (GCV) gene therapy and temozolomide (TMZ). Ad-delo-sr39TK-RGD
Yi-Fu Huang et al.
Oncotarget, 5(14), 5808-5818 (2014-07-30)
Oncogene-mediated cellular transformation is a multistep process involving activation of growth-promoting pathways as well as inactivation of tumor suppressors. We recently found that ISGylation of the p53 tumor suppressor is an important novel mechanism to control its stability. Here we
Ye Zhao et al.
BMC cell biology, 15, 40-40 (2014-12-01)
Endothelial-mesenchymal transition (EndoMT) has been shown to be a major source of myofibroblasts, contributing to kidney fibrosis. However, in vitro study of endothelial cells often relies on culture of isolated primary endothelial cells due to the unavailability of endothelial cell
Hossein Bannazadeh Baghi et al.
Comparative immunology, microbiology and infectious diseases, 37(5-6), 321-329 (2014-12-03)
The mucosal surfaces are important sites of entry for a majority of pathogens, and viruses in particular. The migration of antigen presenting cells (APCs) from the apical side of the mucosal epithelium to the lymph node is a key event
Joëlle Lopez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(6), 2465-2475 (2015-02-13)
Whereas consolidation and reconsolidation are considered dynamic processes requiring protein synthesis, memory retrieval has long been considered a passive readout of previously established plasticity. However, previous findings suggest that memory retrieval may be more dynamic than previously thought. This study
Agnieszka Paradowska-Gorycka et al.
The Journal of rheumatology, 42(2), 170-180 (2014-12-03)
The aim of the study was to identify 2 polymorphic variants in the promoter region of the Foxp3 gene and their possible association with susceptibility to and severity of rheumatoid arthritis (RA). The association between genetic factors and pathogenesis suggests
Yulong Chen et al.
International journal of molecular medicine, 34(5), 1277-1285 (2014-09-06)
Hyperhomocysteinemia (HHcy) is a risk factor for cardiovascular disease. The S-nitrosylation of proteins is involved in the regulation of cardiovascular functions. However, whether homocysteine (Hcy) impairs vascular functions through the inhibition of protein S-nitrosylation in the endothelium remains to be determined. The
Mandy J Peffers et al.
Arthritis research & therapy, 16(3), R110-R110 (2014-06-03)
Cartilage protein distribution and the changes that occur in cartilage ageing and disease are essential in understanding the process of cartilage ageing and age related diseases such as osteoarthritis. The aim of this study was to investigate the peptide profiles
Seyedsina Moeinzadeh et al.
Tissue engineering. Part A, 21(1-2), 134-146 (2014-07-23)
An attractive approach to reduce the undesired side effects of bone morphogenetic proteins (BMPs) in regenerative medicine is to use osteoinductive peptide sequences derived from BMPs. Although the structure and function of BMPs have been studied extensively, there is limited
Shian-Ying Sung et al.
Oncotarget, 5(20), 9911-9929 (2014-10-09)
The L1 cell adhesion molecule (L1CAM) has been implicated in tumor progression of many types of cancers, but its role in prostate cancer and its application in targeted gene therapy have not been investigated. Herein, we demonstrated that the L1CAM
M Fujiya et al.
Oncogene, 33(40), 4847-4856 (2013-10-30)
It is well known that microRNAs (miRs) are abnormally expressed in various cancers and target the messenger RNAs (mRNAs) of cancer-associated genes. While (miRs) are abnormally expressed in various cancers, whether miRs directly target oncogenic proteins is unknown. The present
Metin Ekinci et al.
Current eye research, 39(8), 853-858 (2014-02-08)
To evaluate the toxic effects of chronic lead (Pb) exposure on retinal nerve fiber layer thickness (RNFLT), macular thickness (MT) and choroidal thickness (CT) in battery industry workers. Male factory workers (n = 50) and healthy non-employees (n = 20) participated in the study.
Karina Fischer et al.
The American journal of clinical nutrition, 101(4), 794-807 (2015-04-04)
Visceral (VAT) and subcutaneous abdominal (SAAT) and trunk (STRAT) adipose tissue (AT) have been suggested to be differentially influenced by diet. We investigated whether and to what extent usual patterns of nutrient intake are associated with VAT, SAAT, and STRAT
Nai-Jung Chiang et al.
Clinical and experimental pharmacology & physiology, 41(10), 830-837 (2014-06-10)
Membrane electroporation (MEP) increases the electrical conductivity of the plasma membrane by addition of an external electrical field. Combining MEP-induced current (IMEP ) with antineoplastic agents has been increasingly considered as a new therapeutic manoeuvre, especially in the treatment of
Jiayin Wang et al.
Scientific reports, 5, 9621-9621 (2015-04-11)
Galectin-1 (gal-1), a special lectin with high affinity to β-galactosides, is implicated in protection against ischemic brain injury. The present study investigated transplantation of gal-1-secreting neural stem cell (s-NSC) into ischemic brains and identified the mechanisms underlying protection. To accomplish
Kostas C Nikolaou et al.
The EMBO journal, 34(4), 430-447 (2014-12-18)
PR-SET7-mediated histone 4 lysine 20 methylation has been implicated in mitotic condensation, DNA damage response and replication licensing. Here, we show that PR-SET7 function in the liver is pivotal for maintaining genome integrity. Hepatocyte-specific deletion of PR-SET7 in mouse embryos
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