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Chek Meng Poh et al.
Infection and immunity, 82(11), 4854-4864 (2014-08-27)
CD8(+) T cells play a pathogenic role in the development of murine experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA) infection in C57BL/6 mice. Only a limited number of CD8(+) epitopes have been described. Here, we report the
Hidekazu Takahashi et al.
The Journal of biological chemistry, 287(45), 38158-38167 (2012-09-21)
Metabolic responses of unicellular organisms are mostly acute, transient, and cell-autonomous. Regulation of nutrient uptake in yeast is one such rapid response. High quality nitrogen sources such as NH(4)(+) inhibit uptake of poor nitrogen sources, such as amino acids. Both
Dan Ke et al.
Scandinavian cardiovascular journal : SCJ, 49(1), 64-71 (2015-01-13)
Myocardial ischemia-reperfusion injury (IRI) is associated with activation of the innate immune system and the resultant inflammatory response. Myocardial ischemic preconditioning (IPC) is the most powerful endogenous protective mechanism against myocardial IRI, probably via the role of anti-inflammation. Regulatory T
[Ammonium chloride and the calcium chloride loading test for the diagnosis of renal tubular acidosis].
S Takahashi et al.
Nihon rinsho. Japanese journal of clinical medicine, 43(9), 1836-1842 (1985-09-01)
Wolf Holtkamp et al.
The EMBO journal, 33(9), 1073-1085 (2014-03-13)
Elongation factor G (EF-G) promotes the movement of two tRNAs and the mRNA through the ribosome in each cycle of peptide elongation. During translocation, the tRNAs transiently occupy intermediate positions on both small (30S) and large (50S) ribosomal subunits. How
Massimiliano Secchi et al.
Antimicrobial agents and chemotherapy, 58(10), 6215-6223 (2014-08-13)
R4.0, a synthetic CCL5/RANTES-derived peptide, exerts potent anti-HIV-1 activity via its nonactivating interaction with CCR5, the major HIV-1 coreceptor. CCR5 chronic activation may promote undesirable inflammatory effects and enhance viral infection; thus, receptor antagonism is a necessary requisite. HIV-1 gp120
Maciej Jarosz et al.
Analytica chimica acta, 851, 72-77 (2014-12-03)
Electrospray ionization mass spectrometry (ESI-MS) techniques have been used to characterize the speciation of a Ru(III) anticancer drug, indazolium trans-[tetrachloridobis(1H-indazole) ruthenate(III)], upon its binding to transferrin and the impact of cellular reducing components on drug-transferrin adducts. Using time-of-flight ESI-MS, the
Kyeong Eop Kang et al.
Carbohydrate polymers, 92(2), 1321-1326 (2013-02-13)
This study investigated the effects of NH(4)Cl and MgCl(2) on pretreatment and xylan hydrolysis of miscanthus straw for biofuels production. It was observed that increasing the pretreatment temperature decreased the remaining solid, increased the enzymatic digestibility, and increased the xylan
Shu Cai et al.
Bioresource technology, 130, 536-542 (2013-01-22)
Piperazine is widely used as an intermediate in the manufacture of insecticides, rubber chemicals, corrosion inhibitors, and urethane. In this study, a highly effective piperazine-degrading bacteria strain, TOH, was isolated from the acclimated activated sludge of a pharmaceutical plant. This
Junzheng Du et al.
Journal of virology, 88(21), 12656-12668 (2014-08-22)
Bluetongue virus (BTV), a member of the Orbivirus genus in the Reoviridae family, is a double-capsid insect-borne virus enclosing a genome of 10 double-stranded RNA segments. Like those of other members of the family, BTV virions are nonenveloped particles containing
Sandra Burghoff et al.
BMC cancer, 14, 898-898 (2014-12-04)
Recent studies have suggested that adenosine generated by ecto-5'-nucleotidase (CD73) in the tumor microenvironment plays a major role in promoting tumor growth by suppressing the immune response and stimulating angiogenesis via A2A and A2B receptors. However, adenosine has also been
Filip Mundt et al.
BioMed research international, 2014, 419853-419853 (2014-08-26)
The distinction between malignant and benign pleural effusions is a diagnostic challenge today and measuring soluble biomarkers could add to the diagnostic accuracy. Syndecan-1 is a proteoglycan involved in various cellular functions and is cleaved from the cell surface in
Luc Bruyndonckx et al.
Pediatrics, 135(3), e653-e661 (2015-02-11)
Endothelial dysfunction is the first, although reversible, sign of atherosclerosis and is present in obese adolescents. The primary end point of this study was to investigate the influence of a multicomponent treatment on microvascular function. Additional objectives and end points
Jürgen Brojatsch et al.
PloS one, 9(6), e95032-e95032 (2014-06-04)
Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing agents trigger necrosis and proteolysis of inflammatory proteins
Song Wang et al.
Journal of virology, 88(15), 8375-8385 (2014-05-16)
Although alteration in host cellular translation machinery occurs in virus-infected cells, the role of such alteration and the precise pathogenic processes are not well understood. Influenza A virus (IAV) infection shuts off host cell gene expression at transcriptional and translational
Kerry E Kelly et al.
Journal of the Air & Waste Management Association (1995), 63(5), 575-590 (2013-06-22)
Communities along Utah's Wasatch Front are currently developing strategies to reduce daily average PM2.5 levels to below National Ambient Air Quality Standards during wintertime persistent stable atmospheric conditions, or cold-air pools. Speciated PM2.5 data from the Wasatch Front airshed indicate
Duraisamy Ponnusamy et al.
Infection and immunity, 83(5), 2065-2081 (2015-03-11)
The identification of new virulence factors in Yersinia pestis and understanding their molecular mechanisms during an infection process are necessary in designing a better vaccine or to formulate an appropriate therapeutic intervention. By using a high-throughput, signature-tagged mutagenic approach, we
Karmela Sobczyk et al.
Neurochemical research, 40(2), 274-283 (2014-07-30)
Hepatic encephalopathy (HE) represents a neuropsychiatric syndrome, which evolves as a consequence of a low grade cerebral edema and a concomitant oxidative/nitrosative stress response. Ephrin receptors (EphR) and their ligands (ephrins) regulate astrocytic glutamate uptake and gliotransmitter release thereby governing
Yuwei Yao et al.
eLife, 4 (2015-03-05)
Huntington's disease (HD) represents an important model for neurodegenerative disorders and proteinopathies. It is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) with an expanded polyQ stretch. While Htt is ubiquitously expressed, HD is characterized by selective neurodegeneration
Chris A H Hansell et al.
Immunology and cell biology, 93(2), 167-176 (2014-10-29)
Chemokine-directed leukocyte migration is a critical component of all innate and adaptive immune responses. The atypical chemokine receptor ACKR2 is expressed by lymphatic endothelial cells and scavenges pro-inflammatory CC chemokines to indirectly subdue leukocyte migration. This contributes to the resolution
Ji-Yun Ko et al.
Stem cells and development, 23(15), 1788-1797 (2014-03-22)
The purpose of this study was to examine the in vitro and in vivo osteogenic potential of human induced pluripotent stem cells (hiPSCs) against that of human bone marrow mesenchymal stem cells (hBMMSCs). Embryoid bodies (EBs), which were formed from
Edward P Chen et al.
Carcinogenesis, 35(8), 1788-1797 (2014-03-05)
Cyclooxygenase-2 (COX-2) expression is associated with poor prognosis across a range of human cancers, including breast cancer. The contribution of tumor cell-derived COX-2 to tumorigenesis has been examined in numerous studies; however, the role of stromal-derived COX-2 is ill-defined. Here
Luc Bruyndonckx et al.
The Journal of pediatrics, 165(2), 300-305 (2014-05-21)
To examine the degree of microvascular endothelial dysfunction in relation to classical cardiovascular risk factors, arterial stiffness, and numbers of circulating endothelial progenitor cells (EPCs) and endothelial microparticles (EMPs), in obese and normal-weight children. Cross-sectional study with 57 obese (15.2±1.4
Can Luo et al.
Journal of immunology (Baltimore, Md. : 1950), 193(3), 1080-1089 (2014-06-27)
Ammonia levels are often elevated in patients with cirrhosis or tumors. Patients with these diseases are immunocompromised. In this study, we investigated the effects of ammonia on a member of the immune cell family, the dendritic cells (DCs). Our results
Divyendu Singh et al.
The Journal of biological chemistry, 289(40), 27614-27624 (2014-08-06)
LL-37 is a peptide secreted by human epithelial cells that can lyse bacteria, suppress signaling by Toll-like receptor 4 (TLR4), and enhance signaling to double-stranded RNA (dsRNA) by TLR3. How LL-37 interacts with dsRNA to affect signal transduction by TLR3
Anna Alekseeva et al.
Carbohydrate research, 400, 33-43 (2014-12-03)
There is a growing interest on glycol-split low-molecular weight heparins (gs-LMWHs), obtained by periodate oxidation of LMWHs, optionally followed by borohydride reduction, as potential anticancer and anti-inflammatory drugs. However, their structural characterization is still a challenging task, mainly because of
Anže Martinčič et al.
Journal of chromatography. A, 1371, 168-176 (2014-12-03)
An important step in pharmacological characterisation of a candidate drug is the study of the drugs interactions with serum proteins. In the present work, conjoint liquid chromatography (CLC) was used for separation of ruthenium (Ru)-based drug candidates in human serum.
Karl Peebo et al.
Molecular bioSystems, 11(4), 1184-1193 (2015-02-26)
Cells usually respond to changing growth conditions with a change in the specific growth rate (μ) and adjustment of their proteome to adapt and maintain metabolic efficiency. Description of the principles behind proteome resource allocation is important for understanding metabolic
Gabor Szalai et al.
PloS one, 9(11), e110867-e110867 (2014-11-14)
Soluble fms-like tyrosine kinase (sFlt)-1-e15a, a primate-specific sFlt-1-isoform most abundant in the human placenta in preeclampsia, can induce preeclampsia in mice. This study compared the effects of full-length human (h)sFlt-1-e15a with those of truncated mouse (m)sFlt-1(1-3) used in previous preeclampsia
Zesergio Melo et al.
American journal of physiology. Renal physiology, 305(10), F1402-F1411 (2013-10-04)
K(+)-Cl(-) cotransporter (KCC) isoforms 3 (KCC3) and 4 (KCC4) are expressed at the basolateral membrane of proximal convoluted tubule cells, and KCC4 is present in the basolateral membrane of the thick ascending loop of Henle's limb and α-intercalated cells of
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