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Colby S Shemesh et al.
Pharmaceutical research, 32(5), 1604-1614 (2014-11-20)
The focus of this research was to formulate and evaluate a theranostic liposomal delivery system using indocyanine green (ICG) as a photosensitizer, triggered by near infrared (NIR) irradiation, for in vivo photodynamic therapy (PDT) of breast cancer. Cytotoxicity of PDT
Michelle T Ma et al.
Dalton transactions (Cambridge, England : 2003), 44(11), 4884-4900 (2014-10-30)
Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β(+), Emax = 897 keV, Eav = 397 keV, Eγ = 909 keV, Iγ = 100%) (89)Zr is an appealing radionuclide for immunoPET imaging with whole
Mohammad Mahdi Moein et al.
The Analyst, 140(6), 1939-1946 (2015-02-11)
In this work, a novel method based on in situ molecularly imprinted sol-gel for the surface modification of a polysulfone membrane (PSM) was developed. A modified molecularly imprinted sol-gel polysulfone membrane (MSM) was placed in a homemade plastic tube and
Ali Athab Al-Kinani et al.
Analytical and bioanalytical chemistry, 407(9), 2645-2650 (2015-02-11)
Oxidative damage due to low levels of glutathione (GSH) is one of the main causes of cataract formation. It has been reported that 2-oxothiazolidine-4-carboxylic acid (OTZ), a cysteine prodrug, can increase the cellular level of GSH. Currently, there is no
Atsushi Kambayashi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 236-243 (2014-01-28)
The objective of this research was to characterize the dissolution profile of a poorly soluble drug, diclofenac, from a commercially available multiple-unit enteric coated dosage form, Diclo-Puren® capsules, and to develop a predictive model for its oral pharmacokinetic profile. The
L Pacella-Ince et al.
Human reproduction (Oxford, England), 29(7), 1490-1499 (2014-04-29)
Is the activity of sirtuin 3 (SIRT3) altered in granulosa and cumulus cells from young women with reduced ovarian reserve or women of advanced maternal age? SIRT3 mRNA and active protein in granulosa and cumulus cells were decreased in women
Xing Zhang et al.
Biomedical chromatography : BMC, 29(4), 560-569 (2014-08-29)
This report describes the development and validation of an LC-MS/MS method for the quantitative determination of glyburide (GLB), its five metabolites (M1, M2a, M2b, M3 and M4) and metformin (MET) in plasma and urine of pregnant patients under treatment with
Leslie C Dickson
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 203-210 (2014-08-16)
This paper describes an extension and performance characterization of a quantitative confirmatory multi-residue liquid chromatography-tandem mass spectrometric method for residues of macrolide and lincosamide antibiotics, originally validated for application to bovine kidney tissues, to tissues of salmon, shrimp and tilapia.
Lucille Stuani et al.
Metabolomics : Official journal of the Metabolomic Society, 10(6), 1223-1238 (2014-11-07)
Expansive knowledge of bacterial metabolism has been gained from genome sequencing output, but the high proportion of genes lacking a proper functional annotation in a given genome still impedes the accurate prediction of the metabolism of a cell. To access
S Schauf et al.
Journal of animal physiology and animal nutrition, 102(1), e21-e29 (2017-04-28)
Although studies in rodents and humans have evidenced a weaker effect of fat in comparison to carbohydrates on the suppression of food intake, very few studies have been carried out in this field in dogs. This study investigates the effects
Marion Girod et al.
PloS one, 9(7), e101642-e101642 (2014-07-08)
Accumulation of oxidative damage in proteins correlates with aging since it can cause irreversible and progressive degeneration of almost all cellular functions. Apparently, native protein structures have evolved intrinsic resistance to oxidation since perfectly folded proteins are, by large most
Terence S Crofts et al.
Biochemistry, 53(49), 7805-7815 (2014-11-21)
Cobamides, which include vitamin B₁₂ (cobalamin), are a class of modified tetrapyrroles synthesized exclusively by prokaryotes that function as cofactors for diverse biological processes. Cobamides contain a centrally bound cobalt ion that coordinates to upper and lower axial ligands. The
Li Zhang et al.
Journal of chromatography. A, 1386, 22-30 (2015-02-24)
A new analytical method was established and validated for the analysis of 19 substances of very high concern (SVHCs) in textiles, including phthalic acid esters (PAEs), organotins (OTs), perfluorochemicals (PFCs) and flame retardants (FRs). After ultrasonic extraction in methanol, the
E Roemer et al.
Regulatory toxicology and pharmacology : RTP, 70 Suppl 1, S2-14 (2014-12-17)
This publication introduces a series of six other publications describing the toxicological assessment of kretek cigarettes, i.e., cigarettes characterized primarily by the use of a significant amount of cloves as an ingredient added to the tobacco. This paper presents background
Alptug Atila et al.
Journal of pharmaceutical and biomedical analysis, 97, 33-38 (2014-05-08)
A rapid, simple and sensitive UFLC-MS/MS method was developed and validated for the determination of bosentan in rat plasma using etodolac as an internal standard (IS) after liquid-liquid extraction with diethyl ether-chloroform (4:1, v/v). Bosentan and IS were detected using
Muzaffar Iqbal et al.
Journal of analytical toxicology, 39(2), 106-112 (2014-11-19)
Vilazodone is a novel antidepressant agent, approved by the US Food and Drug Administration (US FDA) for the treatment of major depressive disorder. In this study, a fast sensitive ultra-high performance liquid chromatography-tandem mass spectroscopy method was developed and validated
L Horev et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 29(4), 761-766 (2014-09-02)
Preservatives are important and frequent skin sensitizers, found in a wide range of products for personal and occupational use. According to the European legislation, some cosmetic ingredients are restricted in terms of quantity and a detailed list of ingredients must
Shrilatha Balakrishna et al.
American journal of physiology. Lung cellular and molecular physiology, 307(2), L158-L172 (2014-05-20)
The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches. Recent studies have shown that transient receptor potential vanilloid 4 (TRPV4), an ion channel expressed in pulmonary tissues
Eva Cífková et al.
Analytical and bioanalytical chemistry, 407(3), 991-1002 (2014-10-30)
The comprehensive approach for the lipidomic characterization of human breast cancer and surrounding normal tissues is based on hydrophilic interaction liquid chromatography (HILIC)-electrospray ionization mass spectrometry (ESI-MS) quantitation of polar lipid classes of total lipid extracts followed by multivariate data
Jianjun Liu et al.
PloS one, 9(9), e108816-e108816 (2014-10-01)
Hand, foot, and mouth disease (HFMD) affects more than one million children, is responsible for several hundred child deaths every year in China and is the cause of widespread concerns in society. Only a small fraction of HFMD cases will
Justin Mak et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 94-99 (2015-03-01)
Voriconazole is an azole antifungal drug indicated for use in the treatment of invasive aspergillosis. Due to the large intra- and interindividual variation seen in voriconazole pharmacokinetics along with a high probability of drug-drug interactions, therapeutic drug monitoring is of
Olga Hernández de la Cruz et al.
Journal of proteomics, 111, 46-58 (2014-04-12)
Actin cytoskeleton is an essential structure involved in cell migration and invasion in parasites. In Entamoeba histolytica, the protozoan parasite causing human amoebiasis, the mechanisms underlying the expression of migration-related genes are poorly understood. Here, we investigated the biological effects
Emma-Dune Leriche et al.
Molecules (Basel, Switzerland), 19(12), 20731-20750 (2014-12-17)
Highly branched polyamidoamine (PAMAM) dendrimers presenting biological activities have been envisaged as non-viral gene delivery vectors. They are known to associate with nucleic acid (DNA) in non-covalent complexes via electrostatic interactions. Although their transfection efficiency has been proved, PAMAMs present
Ju-Xiu He et al.
The Journal of pharmacy and pharmacology, 66(11), 1623-1630 (2014-06-26)
To investigate the influence of co-administrated Da-Chaihu-Tang (DCT; a traditional Chinese formulation) on the pharmacokinetics of nifedipine, as well as the safe optimal dosing interval to avoid the adverse interactions. A single dose of DCT was administered with nifedipine simultaneously
Junko Murai et al.
Cell reports, 30(12), 4137-4151 (2020-03-27)
Schlafen 11 (SLFN11) was recently discovered as a cellular restriction factor against replication stress. Here, we show that SLFN11 increases chromatin accessibility genome wide, prominently at active promoters in response to replication stress induced by the checkpoint kinase 1 (CHK1)
Karsten Nödler et al.
International journal of environmental research and public health, 11(10), 10390-10405 (2014-10-14)
Attenuation of micro-contaminants is a very complex field in environmental science and evidence suggests that biodegradation rates of micro-contaminants in the aqueous environment depend on the water matrix. The focus of the study presented here is the systematic comparison of
Elisabete Ricardo et al.
Antimicrobial agents and chemotherapy, 58(8), 4604-4611 (2014-05-29)
Candida krusei is an important agent of opportunistic infections that often displays resistance to several antifungals. We describe here the in vivo acquisition of resistance to voriconazole (VRC) by C. krusei isolates recovered from a leukemia patient during a long
Ji Won Jung et al.
Biological & pharmaceutical bulletin, 38(2), 285-291 (2015-03-10)
DA-9701, a new botanical gastroprokinetic agent, has potential for the management of delayed gastric emptying in Parkinson's disease if it has no central anti-dopaminergic activity. Therefore, we examined the pharmacokinetics of DA-9701 components having dopamine D2 receptor antagonizing activity, tetrahydropalmatine
M A Torres-Vega et al.
Gene therapy, 22(1), 58-64 (2014-10-24)
Hyperammonemia, a condition present in patients with urea cycle disorders (UCDs) or liver diseases, can cause neuropsychiatric complications, which in the worst cases result in brain damage, coma or death. Diverse treatments exist for the treatment of hyperammonemia, but they
Siti Nur Fadzilah Muhsain et al.
Toxicology and applied pharmacology, 282(1), 77-89 (2014-12-06)
The intracellular level of bilirubin (BR), an endogenous antioxidant that is cytotoxic at high concentrations, is tightly controlled within the optimal therapeutic range. We have recently described a concerted intracellular BR regulation by two microsomal enzymes: heme oxygenase 1 (HMOX1)
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