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Chia-Yang Lu et al.
Biochemical pharmacology, 91(1), 40-50 (2014-07-08)
Andrographolide, the major bioactive component of Andrographis paniculata, has been demonstrated to have various biological properties including anti-inflammation, antioxidation, and anti-hepatotoxicity. Oxidative stress is considered a major risk factor in aging, inflammation, cancer, atherosclerosis, and diabetes mellitus. NADPH oxidase is...
Kaisorn L Chaichana et al.
Journal of neuroscience methods, 180(1), 116-125 (2009-05-12)
The discoveries of neural (NSCs) and brain tumor stem cells (BTSCs) in the adult human brain and in brain tumors, respectively, have led to a new era in neuroscience research. These cells represent novel approaches to studying normal phenomena such...
Angélica T Vieira et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(6), 1646-1656 (2015-04-29)
Host-microbial interactions are central in health and disease. Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1β (IL-1β) production and neutrophil recruitment. This study was undertaken to investigate the relevance of gut microbiota, acetate...
B Kocatürk et al.
Journal of thrombosis and haemostasis : JTH, 13(9), 1683-1693 (2015-07-17)
Procoagulant full-length tissue factor (flTF) and its minimally coagulant alternatively spliced isoform (asTF), promote breast cancer (BrCa) progression via different mechanisms. We previously showed that flTF and asTF are expressed by BrCa cells, resulting in autoregulation in a cancer milieu....
Osama Eltboli et al.
BMC pulmonary medicine, 14, 112-112 (2014-07-11)
Eosinophilic airway inflammation is observed in 10-30% of COPD subjects. Whether increased eosinophils or impairment in their clearance by macrophages is associated with the severity and frequency of exacerbations is unknown. We categorised 103 COPD subjects into 4 groups determined...
Luciana de Á Santos et al.
Molecules (Basel, Switzerland), 20(5), 8168-8180 (2015-05-12)
Chagas' disease is caused by a parasitic protozoan and affects the poorest population in the world, causing high mortality and morbidity. As a result of the toxicity and long duration of current treatments, the discovery of novel and more efficacious...
Apolinar Maya-Mendoza et al.
Molecular oncology, 9(3), 601-616 (2014-12-02)
Both Myc and Ras oncogenes impact cellular metabolism, deregulate redox homeostasis and trigger DNA replication stress (RS) that compromises genomic integrity. However, how are such oncogene-induced effects evoked and temporally related, to what extent are these kinetic parameters shared by...
Moran Zur et al.
International journal of pharmaceutics, 489(1-2), 304-310 (2015-05-11)
The purpose of this work was to study the challenges and prospects of regional-dependent absorption in a controlled-release scenario, through the oral biopharmaceutics of the sulfonylurea antidiabetic drug glipizide. The BCS solubility class of glipizide was determined, and its physicochemical...
Anatoly V Rubtsov et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 71-79 (2015-06-03)
In addition to the secretion of Ag-specific Abs, B cells may play an important role in the generation of immune responses by efficiently presenting Ag to T cells. We and other investigators recently described a subpopulation of CD11c(+) B cells...
In Young Hwang et al.
Biomolecules & therapeutics, 23(5), 458-464 (2015-09-04)
Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gastroprotective effects, the inhibitions of HCl•EtOH-induced gastritis...
Daniel Koller et al.
PloS one, 9(10), e110486-e110486 (2014-10-22)
Oxidized phospholipids (oxPLs) are components of oxidized LDL (oxLDL). It is known that oxLDL activates expression of a series of atherogenic genes and their oxPLs contribute to their biological activities. In this study we present the effects of 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC)...
Masahiro Sano et al.
Theriogenology, 84(5), 827-832 (2015-06-29)
The indolizidine alkaloid swainsonine (SW), a potent inhibitor of Golgi α-mannosidase II, is considered the primary toxicant in locoweeds causing toxicity syndrome known as locoism in livestock. Locoweed consumption decreases serum progesterone concentration and causes serious disorders in reproductive functions...
Christian D S Nelson et al.
Journal of virology, 89(7), 3910-3921 (2015-01-23)
JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers...
Sofiane Bakour et al.
Microbial drug resistance (Larchmont, N.Y.), 21(3), 279-285 (2015-01-15)
The aim of this study was to investigate the prevalence and the mechanisms of carbapenem and colistin resistance in Acinetobacter baumannii clinical isolates in an Algerian hospital. Twelve isolates were collected between October 2013 and March 2014. All isolates were...
Takuo Suzuki et al.
mAbs, 7(4), 759-769 (2015-04-22)
Many monoclonal antibodies have been developed for therapy over the last 2 decades. In the development of therapeutic antibodies, the preclinical assessment of an antibody's biodistribution is important for the prediction of the antibody's efficacy and safety. For imaging analyses...
Rama K Koppisetti et al.
Nature communications, 5, 5552-5552 (2014-11-22)
Matrix metalloproteinases (MMPs) regulate tissue remodelling, inflammation and disease progression. Some soluble MMPs are inexplicably active near cell surfaces. Here we demonstrate the binding of MMP-12 directly to bilayers and cellular membranes using paramagnetic NMR and fluorescence. Opposing sides of...
Sung Hyun Kang et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(7), 781-791 (2015-02-04)
Intravesical mitomycin C (MMC) is commonly used to treat bladder cancer but is associated with local adverse effects. Here, we investigate the effects of MMC on release of urothelial mediators and production of inflammatory cytokines. Recovery and the effects of...
Eleftherios K Pefkianakis et al.
Photochemistry and photobiology, 91(5), 1191-1202 (2015-06-30)
A new family of Ru(II)-based photosensitizers was synthesized and systematically characterized. The ligands employed to coordinate the ruthenium metal center were the commercially available 2,2'-bipyridine and a pyridine-quinoline hybrid bearing an anthracene moiety. The complexes obtained carry either PF6- or...
Antoine Lesur et al.
Proteomics. Clinical applications, 9(7-8), 695-705 (2015-02-07)
We report an immunocapture strategy to extract proteins known to harbor driver mutations for a defined cancer type before the simultaneous assessment of their mutational status by MS. Such a method bypasses the sensitivity and selectivity issues encountered during the...
Li-Feng Wang et al.
Molecular neurobiology, 52(1), 478-491 (2014-09-10)
Microwaves have been suggested to induce neuronal injury and increase permeability of the blood-brain barrier (BBB), but the mechanism remains unknown. The role of the vascular endothelial growth factor (VEGF)/Flk-1-Raf/MAPK kinase (MEK)/extracellular-regulated protein kinase (ERK) pathway in structural and functional...
A G Beristain et al.
Oncogene, 34(9), 1160-1173 (2014-03-26)
Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic ablation of Prkar1a, which encodes for the...
Kathryn E Williams et al.
Stem cells (Dayton, Ohio), 33(2), 327-341 (2014-09-05)
Cancer stem cells (CSCs) can avoid or efficiently repair DNA damage from radio and chemotherapy, which suggests they play a role in disease recurrence. Twenty percentage of patients treated with surgery and radiotherapy for ductal carcinoma in situ (DCIS) of...
Hyunku Shin et al.
Journal of nanoscience and nanotechnology, 13(11), 7287-7290 (2013-11-20)
Real-time detection of pH value in a living cell is in central importance for research about cells and diseases. In spite of the great advances in science and technology, pH measurement in a living cell is still limited in spatial...
Mary Anne Conti et al.
Scientific reports, 5, 14068-14068 (2015-09-16)
To investigate the contribution of nonmuscle myosin II-A (NM II-A) to early cardiac development we crossed Myh9 floxed mice and Nkx2.5 cre-recombinase mice. Nkx2.5 is expressed in the early heart (E7.5) and later in the tongue epithelium. Mice homozygous for...
Benjamin S Freedman et al.
Nature communications, 6, 8715-8715 (2015-10-27)
Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specific epithelial physiology, including disease phenotypes...
Houcine Bougherara et al.
Frontiers in immunology, 6, 500-500 (2015-11-04)
T cells play a key role in the battle against cancer. To perform their antitumor activities, T cells need to adequately respond to tumor antigens by establishing contacts with either malignant cells or antigen-presenting cells. These latter functions rely on...
Anna Zajakina et al.
BMC cancer, 14, 460-460 (2014-06-22)
The combination of virotherapy and chemotherapy may enable efficient tumor regression that would be unachievable using either therapy alone. In this study, we investigated the efficiency of transgene delivery and the cytotoxic effects of alphaviral vector in combination with 5-fluorouracil...
Boya Feng et al.
Biochimica et biophysica acta, 1842(12 Pt A), 2345-2356 (2014-10-05)
The D178N mutation of the prion protein (PrP) results in the hereditary prion disease fatal familial insomnia (FFI). Little is known regarding the effects of methionine oxidation on the pathogenesis of D178N-associated FFI. In the present study, we found that...
Yi-Ping Zhu et al.
Oncotarget, 6(16), 14488-14496 (2015-04-22)
Castration-resistant prostate cancer (CRPC) remains the most critical challenge in the clinical management of prostate cancer (PCa). Reactive stromal changes in PCa are likely involved in the emergence of CRPC. In the present study, we identified a novel oncogene termed...
Anthony R Glover et al.
Oncotarget, 6(34), 36675-36688 (2015-10-10)
Adrenocortical carcinoma (ACC) has a poor prognosis with significant unmet clinical need due to late diagnosis, high rates of recurrence/metastasis and poor response to conventional treatment. Replacing tumor suppressor microRNAs (miRNAs) offer a novel therapy, however systemic delivery remains challenging....
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