Showing 1-17 of 17 resultados for "1161586"
Jon M Resch et al.
Synapse (New York, N.Y.), 0 (2014-07-30)
In the central nervous system, cystine import in exchange for glutamate through system x
Huailei Liu et al.
Toxicology letters, 232(2), 349-355 (2014-12-03)
Cancer cells are highly dependent on methionine and cystine (Met-Cys) for survival and proliferation. However, the molecular mechanism is not fully clear. The present study is to investigate the effects of Met-Cys deprivation on glioma cells proliferation. The results showed...
Maria José Alves et al.
Journal of medical microbiology, 63(Pt 3), 471-477 (2014-01-17)
A group of biofilm-producing bacteria isolated from patients with urinary tract infections was evaluated, identifying the main factors contributing to biofilm formation. Among the 156 isolates, 58 (37.2%) were biofilm producers. The bacterial species (P<0.001), together with patient's gender (P...
Jari J Hirvonen et al.
Journal of clinical microbiology, 52(7), 2334-2339 (2014-04-18)
Using a collection (n = 12) of ATCC and known stock isolates, as well as 328 clinical stool specimens, we evaluated the ESwab and the new FecalSwab liquid-based microbiology (LBM) devices for storing and transporting diarrheagenic bacteria. The stock isolates...
Mohamed A Elmonem et al.
Orphanet journal of rare diseases, 9, 155-155 (2014-11-20)
Nephropathic cystinosis is an inherited autosomal recessive lysosomal storage disorder characterized by the pathological accumulation and crystallization of cystine inside different cell types. WBC cystine determination forms the basis for the diagnosis and therapeutic monitoring with the cystine depleting drug...
Raffaele Fabrini et al.
PloS one, 9(11), e112797-e112797 (2014-11-14)
Glutathione transferases (GSTs) are a superfamily of detoxifying enzymes over-expressed in tumor tissues and tentatively proposed as biomarkers for localizing and monitoring injury of specific tissues. Only scarce and contradictory reports exist about the presence and the level of these...
Federico N Soria et al.
The Journal of clinical investigation, 124(8), 3645-3655 (2014-07-19)
During brain ischemia, an excessive release of glutamate triggers neuronal death through the overactivation of NMDA receptors (NMDARs); however, the underlying pathways that alter glutamate homeostasis and whether synaptic or extrasynaptic sites are responsible for excess glutamate remain controversial. Here...
Sabyasachi Baboo et al.
PloS one, 9(6), e99346-e99346 (2014-06-10)
In bacteria, protein synthesis can be coupled to transcription, but in eukaryotes it is believed to occur solely in the cytoplasm. Using pulses as short as 5 s, we find that three analogues--L-azidohomoalanine, puromycin (detected after attaching fluors using 'click'...
Hitomi Kanno et al.
PloS one, 9(12), e116275-e116275 (2015-01-01)
Effects of the kampo medicine yokukansan on gene expression of the cystine/glutamate antiporter system Xc-, which protects against glutamate-induced cytotoxicity, were examined in Pheochromocytoma cells (PC12 cells). Yokukansan inhibited glutamate-induced PC12 cell death. Similar cytoprotective effects were found in Uncaria...
Chao Sun et al.
PloS one, 9(10), e108839-e108839 (2014-10-07)
Inhibitors of the catalytic activity of the 20S proteasome are cytotoxic to tumor cells and are currently in clinical use for treatment of multiple myeloma, whilst the deubiquitinase activity associated with the 19S regulatory subunit of the proteasome is also...
Z X Xie et al.
Journal of animal physiology and animal nutrition, 99(3), 492-500 (2014-10-01)
Increased levels of plasma free amino acids (pFAAs) can disturb the blood glucose levels in patients with obesity, diabetes mellitus and metabolic syndrome (MS) and are associated with enhanced protein oxidation. Oxidation of proteins, especially in the muscles, can promote...
C Mast et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 65(5), 623-631 (2014-11-06)
The use of glutathione (GSH) and sulfate for the detoxification of paracetamol (acetaminophen, APAP) could occur at the expense of the physiological uses of cysteine (Cys). Indeed GSH and sulfate both originate from Cys. Significant APAP-induced Cys loss could generate...
Kamila Borowczyk et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 981-982, 57-64 (2015-01-24)
In this paper, we describe a simple and robust HPLC based method for determination of total low- and high-molecular-mass thiols, protein S-linked thiols and reduced albumin in plasma. The method is based on derivatization of analytes with 2-chloro-1-methylquinolinium tetrafluoroborate, separation...
Jeannette Boutter et al.
Oncotarget, 5(22), 11501-11512 (2014-11-22)
Interactions with the bone marrow microenvironment are essential for leukemia survival and disease progression. We developed an imaging-based RNAi platform to identify protective cues from bone marrow derived mesenchymal stromal cells (MSC) that promote survival of primary acute lymphoblastic leukemia...
Fouzia Khan et al.
Pakistan journal of medical sciences, 30(5), 951-954 (2014-09-17)
To determine the frequency and susceptibility pattern of multi-drug resistant (MDR) Pseudomonas aeruginosa isolated from clinical specimens in Karachi. This cross sectional study was conducted in Microbiology Department, University of Karachi, from January 2012 to January 2013. Clinical specimens were...
Sofi Eriksson et al.
Nature communications, 6, 6479-6479 (2015-03-21)
Across phyla, reduced nicotinamide adenine dinucleotide phosphate (NADPH) transfers intracellular reducing power to thioredoxin reductase-1 (TrxR1) and glutathione reductase (GR), thereby supporting fundamental housekeeping and antioxidant pathways. Here we show that a third, NADPH-independent pathway can bypass the need for...
E Patricia Owen et al.
Pediatric nephrology (Berlin, Germany), 30(4), 595-601 (2014-10-19)
The mutations responsible for cystinosis in South African patients are currently unknown. A pertinent question is whether they are similar to those described elsewhere in the world. Children who were being managed for cystinosis in the Western Cape Province of...

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