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Diclofenac: an update on its mechanism of action and safety profile
Gan, Tong J
Current Medical Research and Opinion, 26(7), 1715-1731 (2010)
Giuseppe Cirillo et al.
Materials science & engineering. C, Materials for biological applications, 48, 499-510 (2015-01-13)
Thermo-responsive hydrogel films, synthesized by UV-initiated radical polymerization, are proposed as delivery devices for non-steroidal anti-inflammatory drugs (Diclofenac sodium and Naproxen). N-isopropylacrylamide and N,N'-ethylenebisacrylamide were chosen as thermo-sensitive monomer and crosslinker, respectively. Infrared spectroscopy was used to assess the incorporation
A Soler Roselló et al.
Archivos espanoles de urologia, 43(8), 831-835 (1990-10-01)
The irritative micturition syndrome is commonly observed following endoscopic surgery for benign prostatic hyperplasia. This condition almost consistently presents following removal of the bladder catheter and may last from 15 to 45 days. The present study was undertaken to determine
Adaptation of a color reaction for spectrophotometric determination of diclofenac sodium and piroxicam in pure form and in pharmaceutical formulations
El-Didamony, AM and Amin, AS
Analytical Letters, 37(6), 1151-1162 (2004)
Daniel D Singer et al.
Cornea, 34(5), 541-543 (2015-04-01)
Topical nonsteroidal antiinflammatory drugs (NSAIDs) are administered topically for a variety of ophthalmologic conditions. Brand diclofenac and brand ketorolac were previously shown to have topical anesthetic effects in addition to analgesic effects. Using the same method, we measured similar anesthetic
George M Martin et al.
Journal of drugs in dermatology : JDD, 11(5), 600-608 (2012-04-25)
Diclofenac sodium 3% gel (Solaraze®) gained US approval for the treatment of actinic keratosis (AK) more than 10 years ago. Since the publication of the pivotal phase 3 studies, numerous clinical studies have assessed use of this therapy in a
Md Moniruzzaman et al.
Journal of ethnopharmacology, 161, 82-85 (2014-12-17)
Hedyotis corymbosa (Linn.) Lam. is a small herb commonly called as khetpapra, traditionally used to treat a wide range of diseases including abdominal pain, arthritis and inflammation. This study was conducted to evaluate the antinociceptive effect of ethanol extract of
Ismail O Ishola et al.
Pharmaceutical biology, 52(9), 1208-1216 (2014-04-05)
The roots of Alafia barteri Oliver (Apocynaceae), Combretum mucronatum Schumach (Combretaceae) and Capparis thonningii Schum (Capparaceae) are used in Traditional African Medicine to alleviate painful and inflammatory conditions. This study investigated the analgesic and anti-inflammatory effects of the methanol root
Thomas G Hammond et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 387-402 (2014-06-07)
Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain carboxylate drugs. The complex rearrangements and reactivities of drug AG have been defined in great detail, and protein adducts of carboxylate drugs
Kristen Moyer et al.
Optometry and vision science : official publication of the American Academy of Optometry, 91(4 Suppl 1), S66-S70 (2014-02-18)
This article reviews the diagnosis and management of a patient with cancer-associated retinopathy (CAR) secondary to small cell lung cancer who developed a rare presentation of CAR, cystoid macular edema (CME). CAR is a rare cause of unexplained, often rapid
Mohd Aftab Alam et al.
Journal of chromatographic science, 53(1), 47-53 (2014-03-29)
A new UPLC-MS-MS method was developed and validated for quantification of diclofenac sodium in rabbit plasma. Acetonitrile-based protein precipitation method was used to extract the drug from plasma samples. Chromatographic separation was carried out on Acquity UPLC(®)BEH phenyl C18 1.7
D Aygün et al.
Histology and histopathology, 27(4), 417-436 (2012-03-01)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of pain, fever, and inflammation associated with rheumatoid arthritis, sports injuries, and temporary pain. However, treatment
Deborah S Keller et al.
Diseases of the colon and rectum, 57(11), 1290-1297 (2014-10-07)
Superior early pain control has been suggested with transversus abdominis plane blocks, but evidence-based recommendations for transversus abdominis plane blocks and their effects on patient outcomes are lacking. The aim of this study was to determine whether transversus abdominis plane
Ashwinee Ragam et al.
Eye & contact lens, 40(5), 283-288 (2014-08-02)
To evaluate the use of topical cyclosporine A (CsA) 1% emulsion in the treatment of chronic ocular surface inflammation (OSI). We conducted a retrospective chart review of patients with various forms of OSI treated with topical CsA 1% from 2001
Grace Carolaine Esquivel Velásquez et al.
Journal of oral & facial pain and headache, 28(2), 153-158 (2014-05-14)
To evaluate the preemptive analgesia of ketoprofen in comparison with diclofenac after mandibular third molar surgery. This study was a double-blind, randomized clinical trial. Forty patients were randomized into two treatment groups (each with 20 patients) by using a series
Yoshihiko Shimokawa et al.
Biological & pharmaceutical bulletin, 37(11), 1727-1735 (2014-11-05)
Delamanid is a new drug for the treatment of multidrug-resistant tuberculosis. Individuals who are co-infected with human immunodeficiency virus and Mycobacterium tuberculosis may require treatment with a number of medications that might interact significantly with the CYP enzyme system as
Improvement of Darier disease with diclofenac sodium 3% gel.
Fernando Millán-Parrilla et al.
Journal of the American Academy of Dermatology, 70(4), e89-e90 (2014-03-19)
Solveig Esmann et al.
The Journal of dermatological treatment, 25(5), 375-379 (2012-12-12)
In recent years, a number of topical treatments suitable for field-directed therapy of actinic keratosis (AK) have been developed. Non-surgical treatment of AK however requires strict adherence by patients. Patients' views on the different possible topical treatments are therefore relevant
Phornchai Pingsusaen et al.
Journal of ethnopharmacology, 162, 199-206 (2014-12-03)
Stahlianthus involucratus (Zingiberaceae) has long been used in traditional medicine to treat inflammation, pain, and fever. However, no pharmacological study of this plant has been reported to confirm these activities. The aim of this study was to investigate the anti-inflammatory
Yasin Cınar et al.
Cutaneous and ocular toxicology, 33(2), 168-171 (2013-07-25)
To evaluate the efficacy of accelerated corneal cross-linking (CXL) procedure for progressive keratoconus. Twenty-three eyes of 23 patients undergone accelerated CXL procedure were evaluated preoperatively and postoperatively at 1st, 3rd and 6th month for uncorrected distant visual acuity (UDVA), best
Laila H Emara et al.
Pharmaceutical development and technology, 19(6), 681-691 (2013-12-11)
The objective of this study was to develop controlled porosity osmotic pump (CPOP) tablets of diclofenac sodium (DS). The influence of different cores (polymers and osmogens) and coats (thickness and porosigen content) on DS release were studied. Results revealed that
Atsushi Kambayashi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 236-243 (2014-01-28)
The objective of this research was to characterize the dissolution profile of a poorly soluble drug, diclofenac, from a commercially available multiple-unit enteric coated dosage form, Diclo-Puren® capsules, and to develop a predictive model for its oral pharmacokinetic profile. The
K Vithani et al.
Pharmaceutical development and technology, 19(5), 531-538 (2013-06-15)
Sustained release diclofenac sodium (Df-Na) solid lipid matrices with Compritol® 888 ATO were developed in this study. The drug/lipid powders were processed via cold and hot melt extrusion at various drug loadings. The influence of the processing temperatures, drug loading
Development and implication of a capillary electrophoresis methodology for ciprofloxacin, paracetamol and diclofenac sodium in pharmaceutical formulations and simultaneously in human urine samples
Solangi AR, et al.
Pakistan Journal of Pharmaceutical Sciences, 24(4), 539-544 (2011)
L K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 193, 29-36 (2014-07-06)
Pharmaceutical and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs) enter the soil environment via irrigation with treated wastewater, groundwater recharge, and land application of biosolids. The transformation and fate of PPCP/EDCs in soil affects their potential for plant
Xiaoyu Niu et al.
Archives of toxicology, 89(1), 107-119 (2014-04-29)
The use of diclofenac (DCF), a nonsteroidal anti-inflammatory drug, is associated with a high prevalence of gastrointestinal side effects. In vivo studies in rodents suggested that reactive metabolites of DCF produced by the liver or the intestine might be responsible
Thomas H Miller et al.
The Science of the total environment, 511, 153-160 (2014-12-30)
The development, characterisation and application of a new analytical method for multi-residue PPCP determination in the freshwater amphipod, Gammarus pulex are presented. Analysis was performed using pulverised liquid extraction (PuLE), solid phase extraction (SPE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Yalong Dang et al.
Drug design, development and therapy, 8, 1441-1449 (2014-09-27)
Our objective was to investigate the efficacy and safety of dexa methasone (DEX) implant for the treatment of pseudophakic cystoid macular edema (PCME) in diabetic patients. This was a prospective, non-randomized, interventional case series of 43 participants. Eighteen patients were
Ugur Celik et al.
Contact lens & anterior eye : the journal of the British Contact Lens Association, 37(6), 420-426 (2014-08-02)
To compare the efficacy, safety and postoperative pain of mechanical versus transepithelial photorefractive keratectomy (PRK) techniques. Cornea and refractive surgery subspecialty. Prospective clinical trial. This prospective comparative study included 84 eyes of 42 patients with myopia who received mechanical PRK
A new threat to European vultures.
Alvaro Camiña et al.
Science (New York, N.Y.), 344(6180), 150-150 (2014-04-12)
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