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Pengkai Ma et al.
International journal of nanomedicine, 10, 2173-2190 (2015-04-04)
Antibody-dendrimer conjugates have the potential to improve the targeting and release of chemotherapeutic drugs at the tumor site while reducing adverse side effects caused by drug accumulation in healthy tissues. In this study, trastuzumab (TMAB), which binds to human epidermal
Christopher J Silva
Prion, 6(2), 163-173 (2012-03-23)
PrP(Sc) is an infectious protein. The only experimentally verified difference between PrP(Sc) and its normal cellular isoform (PrP(C)) is conformational. This work describes an approach to determining the presence of surface exposed or sequestered amino acids present in the PrP(Sc)
Irene Kyrmizi et al.
Nature microbiology, 3(7), 791-803 (2018-06-01)
LC3-associated phagocytosis (LAP) is a non-canonical autophagy pathway regulated by Rubicon, with an emerging role in immune homeostasis and antifungal host defence. Aspergillus cell wall melanin protects conidia (spores) from killing by phagocytes and promotes pathogenicity through blocking nicotinamide adenine
Arun Kumar et al.
ACS applied materials & interfaces, 7(17), 9211-9227 (2015-04-04)
To minimize cardiotoxicity and to increase the bioavailability of doxorubicin, polymersomes based on redox sensitive amphiphilic triblock copolymer poly(polyethylene glycol methacrylate)-poly(caprolactone)-s-s-poly(caprolactone)-poly(polyethylene glycol methacrylate) (pPEGMA-PCL-ss-PCL-pPEGMA) with disulfide linkage were designed and developed. The polymers were synthesized by ring opening polymerization (ROP)
Nopporn Sawatjui et al.
Materials science & engineering. C, Materials for biological applications, 52, 90-96 (2015-05-09)
Tissue engineering is becoming promising for cartilage repair due to the limited self-repair capacity of cartilage tissue. We previously fabricated and characterized a three-dimensional silk fibroin/gelatin-chondroitin sulfate-hyaluronic acid (SF-GCH) scaffold and showed that it could promote proliferation of human bone
Natasha Buwa et al.
FEBS letters, 595(4), 532-547 (2020-12-15)
Integrin-mediated adhesion regulates cellular responses to changes in the mechanical and biochemical properties of the extracellular matrix. Cell-matrix adhesion regulates caveolar endocytosis, dependent on caveolin 1 (Cav1) Tyr14 phosphorylation (pY14Cav1), to control anchorage-dependent signaling. We find that cell-matrix adhesion regulates
Maike G Müller et al.
Infection and immunity, 83(4), 1257-1264 (2015-01-15)
The ability of the human bacterial pathogen Neisseria meningitidis to cause invasive disease depends on survival in the bloodstream via mechanisms to suppress complement activation. In this study, we show that prophage genes coding for T and B cell stimulating
Ping Yang et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(30), 9294-9299 (2012-06-30)
Multifunctional Ag@Au@ phenol formaldehyde resin (PFR) particles loaded with folic acids (FA) have been designed for killing tumor cells through photothermy conversion under the irradiation of near-infrared (NIR) light. Possessing the virtue of good fluorescence, low toxicity, and good targeting
Edvin Memet et al.
eLife, 7 (2018-06-02)
We use optical trapping to continuously bend an isolated microtubule while simultaneously measuring the applied force and the resulting filament strain, thus allowing us to determine its elastic properties over a wide range of applied strains. We find that, while
Huile Gao et al.
Molecular pharmaceutics, 11(8), 2755-2763 (2014-07-02)
Gliomas are hard to treat because of the two barriers involved: the blood-brain barrier and blood-tumor barrier. In this study, a dual-targeting ligand, angiopep-2, and an activatable cell-penetrating peptide (ACP) were functionalized onto nanoparticles for glioma-targeting delivery. The ACP was
Claire Valotteau et al.
ACS applied materials & interfaces, 7(32), 18086-18095 (2015-08-08)
Classical antibacterial surfaces usually involve antiadhesive and/or biocidal strategies. Glycosylated surfaces are usually used to prevent biofilm formation via antiadhesive mechanisms. We report here the first example of a glycosylated surface with biocidal properties created by the covalent grafting of
Yajie Gao et al.
Pharmaceutical research, 32(8), 2649-2662 (2015-02-14)
The purpose of the present study was to design and fabricate endosomal pH-sensitive dual-ligand-modified micellar nanoparticles to achieve enhanced drug delivery to tumor cells and facilitated intracellular drug release. End-group-carboxylated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) and cyclic Arg-Gly-Asp-Tyr-Lys- and anti-prostate specific membrane antigen antibody-modified
Yi Liu et al.
International journal of nanomedicine, 10, 2295-2311 (2015-04-08)
7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with
Noelle M do Nascimento et al.
Biosensors & bioelectronics, 90, 166-173 (2016-11-27)
An autoantigen piezoelectric sensor to quantify specific circulating autoantibodies in human serum is developed. The sensor consisted on a quartz crystal microbalance with dissipation monitoring (QCM-D) where TRIM21 and TROVE2 autoantigens were covalently immobilized, allowing the selective determination of autoantibodies
Suresh Gadde et al.
Advanced healthcare materials, 3(9), 1448-1456 (2014-03-25)
Liver X receptors (LXRs) attenuate inflammation by modulating the expression of key inflammatory genes, making LXRs and their ligands particularly attractive candidates for therapeutic intervention in cardiovascular, metabolic, and/or inflammatory diseases. Herein, enhanced proresolving activity of polymeric nanoparticles (NPs) containing
Yan Xu et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(3), 670-678 (2014-07-22)
The aim of this study was to assess the feasibility of creating extracellular matrix (ECM) scaffolds from mesenchymal stem cells. Bone marrow mesenchymal stem cell (BMSC)-derived ECM (BMSC-dECM) scaffolds were fabricated by lyophilization after crosslinking, without using a decellularization process.
Anna Sankiewicz et al.
Analytical biochemistry, 469, 4-11 (2014-10-15)
We have developed a new method for highly selective determination of the ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) concentration using a surface plasmon resonance imaging (SPRI) technique and two different biosensors. UCH-L1 was captured from a solution by immobilized specific rabbit
Shan Lu et al.
Molecular pharmaceutics, 12(2), 621-629 (2015-01-16)
In this study, we formulated polyplexes with different compositions for codelivery of DNA and small-interfering RNA (siRNA). Since DNA and siRNA have distinctive and complementary morphological characteristics (DNA is long and winding and siRNA is short and rigid), we hypothesized
Min Lu et al.
Carbohydrate polymers, 181, 668-674 (2017-12-20)
In this work, an in situ gelling system composed of glycol chitosan (GC) was fabricated and evaluated regarding its tissue-adhesive, anti-bacterial and hemostatic properties. GC conjugated with 3-(4-hydroxyphenyl) propionic acid gelled immediately after illumination with blue light in the presence
Huifang Li et al.
Talanta, 147, 430-436 (2015-11-26)
A polydimethylsiloxane (PDMS) microfluidic chemiluminescence (CL) immunodevice for sensitive detection of human immunoglobin G (IgG) with the signal amplification strategy was developed in this work. The immunodevice was prepared by covalently immobilizing capture antibodies (Abs) on the silanized microchannel of
Min Li et al.
Colloids and surfaces. B, Biointerfaces, 131, 191-201 (2015-05-20)
Drug loading is a key procedure in the preparation of drug-loaded nano-carriers. In this study, the paclitaxel (PTX)-loaded polymeric complex micelles (FA-P123-PTX/PTX micelles) with double drug-loading strategies were designed and prepared to improve the drug loading percentage of carriers and
Christopher P Landowski et al.
PloS one, 10(8), e0134723-e0134723 (2015-08-27)
The filamentous fungus Trichoderma reesei has tremendous capability to secrete proteins. Therefore, it would be an excellent host for producing high levels of therapeutic proteins at low cost. Developing a filamentous fungus to produce sensitive therapeutic proteins requires that protease
Kuldeep Kumar Bansal et al.
Pharmaceutics, 12(8) (2020-08-05)
Biodegradable polymers from renewable resources have attracted much attention in recent years within the biomedical field. Lately, poly(δ-decalactone) based copolymer micelles have emerged as a potential drug delivery carrier material as a sustainable alternative to fossil-based polymers. However, their intracellular
Louise Mc Grath-Lone et al.
BMC cancer, 15, 618-618 (2015-09-06)
Inequalities in cancer research participation are thought to exist with certain groups under-represented in research populations; however, much of the evidence is based on small-scale studies. The aim of this study was to explore data from in-depth interviews with cancer
Rongqiang Liao et al.
Chembiochem : a European journal of chemical biology, 16(11), 1622-1628 (2015-06-03)
A targeting gene carrier for cancer-specific delivery was successfully developed through a "multilayer bricks-mortar" strategy. The gene carrier was composed of adamantane-functionalized folic acid (FA-AD), an adamantane-functionalized poly(ethylene glycol) derivative (PEG-AD), and β-cyclodextrin-grafted low-molecular-weight branched polyethylenimine (PEI-CD). Carriers produced by
Wei Wang et al.
Immunological investigations, 44(4), 385-399 (2015-05-06)
The strategy of specifically depleting antigen-specific T cells can potentially be used for the treatment of allograft rejection and autoimmunity because it does not suppress the overall immune systems. In this study, we generated killer polylactic-co-glycolic acid (PLGA) microspheres by
Tisen Xu et al.
Biosensors & bioelectronics, 73, 167-173 (2015-06-13)
A novel sandwich-type electrochemical immunoassay with sensitivity enhancement was developed for quantitative detection of tissue polypeptide antigen (TPA) by coupling with target-induced tyramine signal amplification on prussian blue-gold hybrid nanostructures. The immunosensor was prepared through immobilizing anti-TPA capture antibody on
Chaemyeong Lee et al.
Colloids and surfaces. B, Biointerfaces, 127, 89-95 (2015-02-07)
Adopting the strong metal binding moiety of a mussel protein, a novel bolaamphiphile molecule was prepared and applied to the fabrication of magnetic core-shell nanoparticles. The novel bolaamphiphile molecule with 3,4-dihydroxyphenylalanine (DOPA) end groups was synthesized and its self-assembly was
Manuel Valero et al.
Nature neuroscience, 18(9), 1281-1290 (2015-07-28)
Sharp-wave ripples represent a prominent synchronous activity pattern in the mammalian hippocampus during sleep and immobility. GABAergic interneuronal types are silenced or fire during these events, but the mechanism of pyramidal cell (PC) participation remains elusive. We found opposite membrane
Rees F Garmann et al.
Journal of virology, 88(18), 10472-10479 (2014-06-27)
We have recently discovered (R. D. Cadena-Nava et al., J. Virol. 86:3318-3326, 2012, doi:10.1128/JVI.06566-11) that the in vitro packaging of RNA by the capsid protein (CP) of cowpea chlorotic mottle virus is optimal when there is a significant excess of
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