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Xing-Jie Bao et al.
The Tohoku journal of experimental medicine, 244(4), 283-290 (2018-04-13)
Essential hypertension (EH) is a multifactorial disease. Interferon-γ (IFN-γ) plays an important role in the onset of EH through cytokine-mediated systemic inflammatory responses. We aimed to determine whether the methylation status of the IFN-γ gene (IFNG) promoter is involved in...
Xie Zhang et al.
World journal of gastroenterology, 21(9), 2629-2637 (2015-03-12)
To investigate GATA5, SFRP2, and ITGA4 methylation in plasma DNA as noninvasive biomarkers for colorectal cancer (CRC) or adenomas. There were 57 CRC patients, 30 adenomas patients, and 47 control patients enrolled in this study. Methylation-specific polymerase chain reaction was...
R Herruzo et al.
Journal of applied microbiology, 128(5), 1339-1346 (2019-12-21)
ChloraPrep™ (CHP) is a clear solution of 2% (w/v) chlorhexidine (CHG) in 70% (v/v) isopropyl alcohol (IPA) administered with a specially designed sterile single-use applicator in which a tinting agent can be added to the CHP solution upon activation of...
Wenxiao Zhang et al.
Plant science : an international journal of experimental plant biology, 291, 110326-110326 (2020-01-14)
Transcription factor activation and DNA methylation are important plant responses to abiotic stress. Here, we established that the salinity stress-induced expression of the soybean (Glycine max) transcription factor-encoding gene GmMYB84 relies on DNA methylation. The level of DNA methylation at...
Alexander Unterberger et al.
Methods in molecular biology (Clifton, N.J.), 863, 303-317 (2012-02-24)
The disruption and alteration of genomic methylation patterns is a hallmark of cancer and other disease states. Understanding and characterizing genome-wide methylation will have a profound effect on our understanding of tumorigenesis and provide novel avenues for therapy. This chapter...
Debodipta Das et al.
Clinical epigenetics, 11(1), 178-178 (2019-12-05)
Gingivo-buccal oral squamous cell carcinoma (OSCC-GB) is the most common cancer among men in India and is associated with high mortality. Although OSCC-GB is known to be quite different from tongue cancer in its genomic presentation and its clinical behavior...
Ana-Luisa Silva et al.
BMC cancer, 14, 891-891 (2014-11-30)
There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive stage. Here, we investigated whether epigenetic silencing of Wnt antagonists...
Meixian Huang et al.
Cancer medicine, 7(4), 1297-1316 (2018-02-24)
Cytosine arabinoside (Ara-C) is one of the key drugs for the treatment of acute myeloid leukemia. It is also used for consolidation therapy of acute lymphoblastic leukemia (ALL). Ara-C is a deoxyadenosine analog and is phosphorylated to form cytosine arabinoside...
Shanchun Guo et al.
PloS one, 7(8), e43610-e43610 (2012-09-07)
TREX (transcription/export) is a multiprotein complex that plays a key role in the transcriptional elongation and transport of mRNA from the nucleus to the cytoplasm. We previously reported the purification of the human TREX protein and found that expression of...
Hewen Wu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(2), 461-474 (2018-07-18)
Endoplasmic reticulum lipid raft-associated 2 (ERLIN2) is reported to be overexpressed in human breast cancer cells and plays an important role in cell proliferation. MicroRNAs (miRNAs) act as post-transcriptional regulators of gene expression and are involved in the development of...
Ayumi Nakagaki et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 29(9-10), 680-689 (2018-09-19)
Necdin (Ndn) transgenic (Tg) mice were generated with a bacterial artificial chromosome (BAC) clone. Droplet digital PCR (ddPCR) and inverse PCR methods revealed that the transgene consisted of four fragments with a total length of 171 kb. Two of these fragments...
Hitomi Matsuzaki et al.
Epigenetics & chromatin, 13(1), 2-2 (2020-01-16)
Paternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 genes. The molecular mechanism by which differential methylation of the H19 ICR is established during gametogenesis and maintained after fertilization, however, is not...
Yui Murata et al.
Scientific reports, 7(1), 13624-13624 (2017-10-21)
Retrotransposon long interspersed nuclear element-1 (LINE-1) occupies a large proportion of the mammalian genome, comprising approximately 100,000 genomic copies in mice. Epigenetic status of the 5' untranslated region (5'-UTR) of LINE-1 is critical for its promoter activity. DNA methylation levels...
Guang Hua Li et al.
Pathology international, 67(11), 564-574 (2017-10-14)
Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH...
Daniela Ferreira et al.
Frontiers in genetics, 10, 101-101 (2019-02-28)
Satellite ncRNAs are emerging as key players in cell and cancer pathways. Cancer-linked satellite DNA hypomethylation seems to be responsible for the overexpression of satellite non-coding DNAs in several tumors. FA-SAT is the major satellite DNA of Felis catus and...
Iván Meneses-Morales et al.
Molecular carcinogenesis, 58(6), 887-897 (2019-01-19)
The knowledge about the role of calcium-regulated pathways in cancer cell growth and differentiation could be useful for the development of new therapeutic approaches to diminish its mortality. The ATP2A genes encode for SERCA pumps, which modulate cytosolic Ca2+ concentration...
Michaela Wrage et al.
International journal of cancer, 136(10), 2264-2272 (2014-10-30)
For better lung cancer diagnosis and therapy, early detection markers of tumor dissemination are urgently needed, as most lung cancers do not show symptoms until extensive metastasis formation has already taken place. Our previous studies showed that in non-small cell...
Asghar Ghasemi et al.
Clinical laboratory, 63(7), 1079-1088 (2017-08-10)
Deregulated expressions of tumor-suppressive microRNAs (miRNAs) by epigenetic aberrations has a critical role in tumorigenesis. The aim of the present study was to investigate the epigenetic aberrations of miR205 and to understand how this modification may contribute to molecular events...
Hyang Sook Seol et al.
Cancer letters, 353(2), 232-241 (2014-07-27)
The role of microRNAs (miRNAs) in carcinogenesis as tumor suppressors or oncogenes has been widely reported. Epigenetic change is one of the mechanisms of transcriptional silencing of miRNAs in cancer. To identify lung cancer-related miRNAs that are mediated by histone...
Gang Liu et al.
Frontiers in bioengineering and biotechnology, 7, 364-364 (2020-01-11)
Background: Adolescent idiopathic scoliosis (AIS) is a complex disease affecting a large number of teenagers, especially in female. This study reveals novel epigenetic perturbation to the pathogenesis of AIS. Methods: A female monozygotic (MZ) twin pair discordant for AIS were...
Anilkumar Yadav et al.
Biomacromolecules, 21(2), 589-596 (2019-12-14)
Cellulose-derived nanographene oxide (nGO)-type carbon dot reinforced porous scaffolds of poly(ε-caprolactone) (PCL) were developed as templates from high internal phase emulsions (HIPE). The mechanical strength, structural integrity, and reusability of the scaffolds were enhanced via in situ cross-linking. An oil-in-oil...
K J Nagarajan et al.
Carbohydrate polymers, 235, 115997-115997 (2020-03-04)
The Used Disposal Paper Cups (UDPCs) have become a concern to the solid waste management sector as scientists triggered the problems in recent years, to proceed forward in developing the process for this issue. Based on this concern, the present...
Michael H McGuire et al.
EBioMedicine, 43, 127-137 (2019-05-06)
Investigations into the function of non-promoter DNA methylation have yielded new insights into the epigenetic regulation of gene expression. However, integrated genome-wide non-promoter DNA methylation and gene expression analyses across a wide number of tumour types and corresponding normal tissues...
Huoqun Gan et al.
Science advances, 6(14), eaay2793-eaay2793 (2020-04-10)
Activation-induced cytidine deaminase (AID) mediates immunoglobulin class switch DNA recombination (CSR) and somatic hypermutation (SHM), critical processes for maturation of the antibody response. Epigenetic factors, such as histone deacetylases (HDACs), would underpin B cell differentiation stage-specific AID expression. Here, we...
Lina Leiss et al.
Glia, 68(5), 979-988 (2019-11-27)
The microenvironment and architecture of peritumoral tissue have been suggested to affect permissiveness for infiltration of malignant cells. Astrocytes constitute a heterogeneous population of cells and have been linked to proliferation, migration, and drug sensitivity of glioblastoma (GBM) cells. Through...
Milena N Leseva et al.
Human molecular genetics, 29(2), 335-350 (2019-12-24)
Despite the many advances made in the diagnosis and management of preeclampsia, this syndrome remains a leading cause of maternal mortality and life-long morbidity, as well as adverse fetal outcomes. Successful prediction and therapeutic intervention require an improved understanding of...
Maria Maryam et al.
Journal of medical virology, 90(9), 1516-1523 (2018-05-10)
Epigenetic modifications such as DNA methylation contribute to progression of hepatitis C virus (HCV) infection to life-threatening hepatocellular carcinoma (HCC) by promoting the silencing of tumor suppressor genes through DNA hypermethylation and by causing genomic instability through global hypomethylation. However...
Shiro Iwagami et al.
Annals of surgical oncology, 19(8), 2726-2732 (2011-12-22)
Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. DNA methylation in the long interspersed nucleotide element 1 L1 (LINE-1) repetitive element is a good indicator of global DNA methylation level. LINE-1 methylation is a useful marker for...
Tobias Weinmann et al.
BMC public health, 15, 1210-1210 (2015-12-08)
Atopic diseases are a major burden of disease on a global scale. Regarding their aetiology, the early years of life are assumed to play a crucial role. In addition, there is growing evidence that elucidating the impact of cross-generational effects...
Reza Mousavi Ardehaie et al.
Bioengineered, 8(5), 555-564 (2017-02-01)
Cancers are among the most serious threats of human health worldwide. Survival and mortality rates of colorectal cancer (CRC) strongly depend on the early diagnosis. The aberrant methylation pattern of genes as a diagnostic biomarker can serve as a practical...
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