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Shaojuan Song et al.
PloS one, 9(9), e107685-e107685 (2014-09-23)
Antioxidant enzymes play a major role in defending against oxidative damage by copper. However, few studies have been performed to determine which antioxidant enzymes respond to and are necessary for copper detoxification. In this study, we examined both the activities
Snežana D Marković et al.
General physiology and biophysics, 33(4), 393-401 (2014-08-26)
The effects of nitroglycerin (glyceryl trinitrate - GTN) are mediated by liberated nitric oxide (NO) and formed reactive nitrogen species, which induces oxidative stress during biotransformation in red blood cells (RBCs). The aim of this study was to evaluate effects
R Li et al.
Allergy, 67(10), 1250-1258 (2012-08-23)
We previously reported that prior nasal administration of highly attenuated Bordetella pertussis BPZE1 provides effective and sustained protection against lethal challenge with influenza A viruses. The protective effect was mediated by suppressing the production of major pro-inflammatory mediators. To further
Nelson Leonel Martínez-Rodríguez et al.
Toxicology in vitro : an international journal published in association with BIBRA, 57, 54-61 (2019-02-17)
Ferrite nanoparticles (NPs) have gained attention in biomedicine due to their many potential applications, such as targeted drug delivery, their use as contrast agents for magnetic resonance imaging and oncological treatments. The information about the risk effects of ferrite NPs
Qi Yin et al.
Journal of biomedical nanotechnology, 11(10), 1764-1775 (2015-10-28)
The clinical success of anthracyclines-containing chemotherapy for breast cancer is mainly restricted by cardiac damage and the development of multidrug resistance (MDR). For efficient reversal of drug resistance, doxorubicin (DOX) loaded multifunctional bioreducible micelles were constructed from a new amphiphilic
Felix C Weber et al.
The Journal of experimental medicine, 212(1), 15-22 (2014-12-17)
Allergic contact dermatitis and its animal model, contact hypersensitivity (CHS), are T cell-mediated inflammatory skin diseases induced by contact allergens. Though numerous cellular and molecular players are known, the mechanism of chemical-induced sensitization remains poorly understood. Here, we identify neutrophils
Flavia Bieczynski et al.
Aquatic toxicology (Amsterdam, Netherlands), 154, 97-106 (2014-05-29)
We studied Abcc mediated-transport in middle and posterior intestine of the rainbow trout, Oncorhynchus mykiss. Luminal and serosal transport were evaluated in everted and non-everted intestinal sacs, respectively, incubated with 1-chloro-2,4-dinitrobenzene (CDNB; 200 μM). CDNB enters the cells and is
X-Q Yang et al.
Bulletin of entomological research, 105(3), 316-325 (2015-03-18)
The codling moth Cydia pomonella (L.) is an economically important fruit pest and it has been directly targeted by insecticides worldwide. Serious resistance to insecticides has been reported in many countries. As one of the most serious invasive pest, the
Nora L Krutz et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 515-523 (2015-07-18)
The monoterpene ascaridole, a fairly stable endoperoxide found in essential oils such as tea tree oil can provoke allergic contact dermatitis which has been evidenced under patch test conditions. However, concomitantly we observed irritative skin reactions that demand further data
Iva Boušová et al.
Xenobiotica; the fate of foreign compounds in biological systems, 42(9), 872-879 (2012-03-31)
Flavonoids are known to modulate catalytic activity and expression of various enzymes. Glutathione S-transferases (GSTs) are the important biotransformation enzymes defending cells against potentially toxic xenobiotics. Therefore, the modulation of GST activity may influence detoxification of xenobiotics. The aim of
Jae Ho Choi et al.
Environmental toxicology and pharmacology, 33(3), 446-452 (2012-03-13)
Platycodi Radix has been used to treat chronic diseases, such as bronchitis, asthma, and hyperlipidemia. In this study, we examined the effect of an aqueous extract, Changkil (CK), from the root of Platycodi Radix on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like
Denis Benito et al.
The Science of the total environment, 689, 1087-1103 (2019-08-31)
For reliable mussel monitoring programmes based on biomarkers, regionally relevant reference values and their natural variability need to be known. The Baltic Sea exhibits high inter-regional and seasonal variability in physical factors such as salinity, temperature and primary production. The
Ritika Nagar et al.
European journal of drug metabolism and pharmacokinetics, 40(1), 45-51 (2014-01-30)
Glutathione S-transferases (GSTs) play an important role in the biotransformation of endogenous compounds and xenobiotics as well as in the metabolic inactivation of pharmacologically active substances, including anticancer drugs. Using cisplatin as the prototype drug, we investigated if any correlation
Jin Kyeong Choi et al.
Toxicology and applied pharmacology, 269(1), 72-80 (2013-03-19)
Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common allergic and inflammatory skin diseases caused by a combination of eczema, scratching, pruritus, and cutaneous sensitization with allergens. This paper examines whether oleanolic acid acetate (OAA) modulates AD and ACD
Raffaele Fabrini et al.
PloS one, 9(11), e112797-e112797 (2014-11-14)
Glutathione transferases (GSTs) are a superfamily of detoxifying enzymes over-expressed in tumor tissues and tentatively proposed as biomarkers for localizing and monitoring injury of specific tissues. Only scarce and contradictory reports exist about the presence and the level of these
Zhaoguo Liu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 82, 12-18 (2015-05-10)
Inflammation and oxidative stress have been implicated in various pathological processes including skin tumorigenesis. Skin cancer is the most common form of cancer responsible for considerable morbidity and mortality, the treatment progress of which remains slow though. Therefore, chemoprevention and
Noomi Asker et al.
Environmental toxicology and chemistry, 34(7), 1511-1523 (2015-02-11)
A broad biomarker approach was applied to study the effects of marine pollution along the Swedish west coast using the teleost eelpout (Zoarces viviparus) as the sentinel species. Measurements were performed on different biological levels, from the molecular to the
Augustine Arukwe et al.
PloS one, 10(6), e0130002-e0130002 (2015-06-19)
In the present study, the biotransformation and oxidative stress responses in relation to chemical burden in the liver of male and female Nile crocodiles--Crocodylus niloticus--from a commercial crocodile farm passively exposed to various anthropogenic aquatic pollutants was investigated. In general
Le Son Tran et al.
Journal of innate immunity, 7(4), 392-404 (2015-02-28)
Human papillomaviruses (HPVs) have evoked numerous mechanisms to subvert host innate immunity and establish a local immunosuppressive environment to facilitate persistent virus infection. Topical application of 2,4-dinitrochlorobenzene (DNCB) was speculated to overcome this immunosuppressive environment and was employed in the
Francine R Ianiski et al.
The Journal of pharmacy and pharmacology, 66(12), 1747-1754 (2014-08-19)
In this study, the antioxidant action of ((4-tert-butylcyclohexylidene) methyl) (4-methoxystyryl) sulfide, a novel unsymmetrical divinyl sulfide, against oxidative damage induced by sodium nitroprusside (SNP) in brains of mice was investigated. Mice received SNP (0.335 μmol/site, intracerebroventricular) 30 min after administration of sulfide
Gabriela Chaufan et al.
Chemical research in toxicology, 32(4), 745-752 (2019-02-01)
The fungicide agents are a key component in the fruits and vegetables production. The Iprodione residues are one of the pesticide more frequently found in food products. The available data about the cytotoxicity of iprodione and its metabolites are scarce
Chun Wang et al.
International immunopharmacology, 24(2), 325-334 (2015-01-04)
The present study aimed to investigate the regulation exerted by the total glucosides of paeony (TGP) on the production of interleukin-2 (IL-2), IL-4, IL-10 and IL-17 in the serum and lymphocytes of mice with allergic contact dermatitis (ACD). ACD in
Sanjib Bhattacharya et al.
Journal of dietary supplements, 11(3), 248-261 (2014-07-25)
The present study investigated the alleviative effect of aqueous extract of Trichosanthes dioica fruit (AQTD) against arsenic induced cardiotoxicity in Wistar albino rats. AQTD (50 and 100 mg/kg) was administered orally to rats for 20 consecutive days before oral administration
Ivan V Maksymiv et al.
Pesticide biochemistry and physiology, 122, 67-75 (2015-06-15)
The effects of 96 h exposure to 7.14, 35.7, or 71.4 mg L(-1) of Sencor were studied on liver and plasma parameters in goldfish, Carassius auratus L. Goldfish exposure to 71.4 mg L(-1) of Sencor for 96 h resulted in a decrease in glucose
Valentina Galbiati et al.
The Journal of investigative dermatology, 134(11), 2719-2727 (2014-05-02)
Keratinocytes have a key role in all phases of allergic contact dermatitis. We have recently identified the possibility to use IL-18 production for the in vitro identification of contact allergens. The purpose of this study was to characterize the molecular
Camila R Murussi et al.
Archives of environmental contamination and toxicology, 68(4), 646-654 (2015-03-18)
Clomazone is considered a potential contaminant of groundwater and is persistent in the environment. To verify the effects of clomazone in Cyprinus carpio and Rhamdia quelen, a method that combines biomarker responses into an index of "integrated biomarker response" (IBR)
Rachana D Sharma et al.
Journal of pineal research, 59(2), 240-254 (2015-06-24)
Oxidative stress-induced methemoglobinemia remained an untouched area in venom pharmacology till date. This study for the first time explored the potential of animal venoms to oxidize hemoglobin to methemoglobin. In in vitro whole-blood assay, methemoglobin forming ability of venoms varied
Gabsik Yang et al.
Immunopharmacology and immunotoxicology, 34(3), 413-418 (2012-05-09)
The flower of Chrysanthemum boreale has traditionally been used for treatment of various inflammatory disease including atopic dermatitis (AD). However, its action on AD is unclear. Therefore, we investigated the effect of CB on AD using NC/Nga mice as an
Mahboobeh Sharifi et al.
Insect science, 22(5), 639-650 (2014-07-06)
Insecticidal effects of 4-hexylresorcinol, a phenoloxidase (PO) inhibitor, were determined on Hyphantria cunea (Drury) under laboratory conditions. The LC50 for the 15-d-old larvae was estimated to be 2.95 g/L after 96 h exposure. The activities of glutathione S-transferase (GST) and
Davorka K Hackenberger et al.
Chemosphere, 224, 572-579 (2019-03-06)
Organisms in soil are often exposed to different mixtures of contaminants. These contaminants may interact with each other and, consequently, may have a different effect on organisms than each of them alone. We wanted to investigate possible effects of ZnO
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