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Z X Xie et al.
Journal of animal physiology and animal nutrition, 99(3), 492-500 (2014-10-01)
Increased levels of plasma free amino acids (pFAAs) can disturb the blood glucose levels in patients with obesity, diabetes mellitus and metabolic syndrome (MS) and are associated with enhanced protein oxidation. Oxidation of proteins, especially in the muscles, can promote
Xiaomei Yang et al.
The Science of the total environment, 512-513, 406-414 (2015-02-04)
Repeated applications of glyphosate may contaminate the soil and water and threaten their quality both within the environmental system and beyond it through water erosion related processes and leaching. In this study, we focused on the transport of glyphosate and
William L Scott et al.
Journal of combinatorial chemistry, 11(1), 34-43 (2008-12-25)
For the successful implementation of Distributed Drug Discovery (D(3)) (outlined in the accompanying Perspective), students, in the course of their educational laboratories, must be able to reproducibly make new, high quality, molecules with potential for biological activity. This article reports
J Bernal et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(31), 3290-3296 (2010-11-26)
A simple and fast method has been developed and validated to measure glyphosate (GLYP) and aminomethylphosphonic acid (AMPA) in rat plasma based on reversed-phase high performance liquid chromatography (RP-HPLC) coupled to fluorescence (FLD) and electrospray ionization mass spectrometry (ESI-MS) detection.
Chengke Li et al.
Methods in molecular biology (Clifton, N.J.), 970, 307-317 (2013-01-04)
Macrocyclic antibiotics, especially vancomycin, represent a class of versatile chiral selectors for enantioseparations by capillary electrophoresis (CE). In this chapter, we describe the protocol for performing CE enantioseparations with vancomycin as the chiral selector. Dynamic coating of the capillary with
Sri Puvanesvari Gannasin et al.
Food chemistry, 182, 292-301 (2015-04-07)
Tamarillo (Solanum betaceum Cav.) is an underutilised fruit in Malaysia. The fruit, however, contains good proportions of soluble fibre, protein, starch, anthocyanins and carotenoids. Amongst the fruits, only tamarillo mesocarp contains both polar (anthocyanins) and non-polar (carotenoids) pigments. The ability
Jörg Ziegler et al.
Amino acids, 46(12), 2799-2808 (2014-09-15)
A new method for the determination of amino acids is presented. It combines established methods for the derivatization of primary and secondary amino groups with 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) with the subsequent amino acid specific detection of the derivatives by LC-ESI-MS/MS
Jing Zhu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 31(22), 1865-1868 (2007-02-09)
To establish a reversed-phase high performance liquid chromatorgraphy (RP-HPLC) method for detecting the dencichine in Panax notoginseng extracts and drug preparations. Dencichine was extracted with the borate buffer (pH 9. 18) and the clear supernatant was used for the derivatization.
Bahareh Mohammadi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 880(1), 12-18 (2011-12-17)
In High Performance Liquid Chromatographic (HPLC) determination of chemicals with acidic functions, different labeling agents are used to improve sensitivity of the assay. 9-Fluorenylmethyl chloroformate (FMOC-Cl), on the other hand, is a suitable labeling agent, which reacts with both primary
Wahid Khan et al.
Drug testing and analysis, 3(6), 363-372 (2011-06-24)
Paromomycin (PM) is an aminoglycoside antibiotic, first isolated in the 1950s, and approved in 2006 for treatment of visceral leishmaniasis. Although isolated six decades back, sufficient information essential for development of pharmaceutical formulation is not available for PM. The purpose
Joonho Bae et al.
International journal of pharmaceutics, 480(1-2), 37-47 (2015-01-18)
We prepared an injectable depot system for the long-term delivery of alendronate using a solid/water/oil/water multiple emulsion technique with poly(lactic-co-glycolic acid) as a carrier. The microparticles were spherical with smooth surfaces, ranging from 20 to 70 μm in size. The
Marco Napoli et al.
Journal of environmental quality, 44(5), 1667-1673 (2015-10-06)
Glyphosate [-(phosphono-methyl)-glycine] is the main herbicide used in the Chianti vineyards. Considering the pollution risk of the water table and that the vineyard tile drain may deliver this pollutant into nearby streams, the objective of the present study was to
Ingrid Freuze et al.
Journal of chromatography. A, 1175(2), 197-206 (2007-11-21)
Experimental and theoretical influence of multivalent cations on the analysis of glyphosate and aminomethyl phosphonic acid (AMPA) was studied in pure water and in one surface water. The procedure chosen, based on derivatization with FMOC-Cl, HPLC separation, and fluorescence detection
Sourav Majumdar et al.
International journal of biological macromolecules, 79, 477-489 (2015-05-13)
Fibrin(ogen)olytic enzymes offer great promise for the treatment of thrombosis associated disorders. The present study describes the characterization of an extracellular fibrin(ogen)olytic serine protease (named Bacethrombase) purified from the Bacillus cereus strain FF01. The molecular mass of the Bacethrombase was
Angela Patti et al.
Chirality, 20(2), 63-68 (2007-11-15)
The HPLC enantioseparation of the last generation antidepressive drug milnacipran (+/-)-1 was investigated on different cellulose-based chiral stationary phases (CSPs). On carbamate-type columns, Chiralcel OD and OD-H (+/-)-1 could be separated with alpha value about 1.20 but the resolution was
Bahareh Mohammadi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 928, 32-36 (2013-04-20)
Topiramate is an antiepileptic agent, which is structurally different from the other anticonvulsants. The drug has no UV-Vis absorption or emits fluorescence. Thus for its analysis using high performance liquid chromatography (HPLC) with conventional UV or fluorescence detectors, the drug
Miyako Nakano et al.
Glycobiology, 19(2), 135-143 (2008-10-29)
It is well known that most protein therapeutics such as monoclonal antibody pharmaceuticals and other biopharmaceuticals including cancer biomarkers are glycoproteins, and thus the development of high-throughput and sensitive analytical methods for glycans is essential in terms of their determination
A Jámbor et al.
Journal of chromatography. A, 1216(15), 3064-3077 (2009-02-14)
A literature overview is given of HPLC methods currently in use to determine amino acids as their 9-fluorenylmethyloxycarbonyl (FMOC) derivatives. On the basis of the detailed literature overview an exhaustive derivatization study was performed with 22 amino acids, applying photodiode
Virender Singh et al.
Soft matter, 11(26), 5353-5364 (2015-06-11)
Hydrogels of low molecular weight molecules are important in biomedical applications. Multiple factors are responsible for hydrogel formation, but their role in governing self-assembly to hydrogel formation is poorly understood. Herein, we report the hydrogel formation of fluorenylmethyloxycarbonyl phenylalanine (FmocF)
Divyabharathi Chepyala et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 980, 48-54 (2015-01-16)
Recently, colistin has become one of the most important drugs for treating infections caused by multidrug-resistant Gram-negative bacteria. Therapeutic drug monitoring is recommended to ensure the safety and efficacy of colistin and to improve clinical outcomes. This study developed an
Yang Chen et al.
Analytical and bioanalytical chemistry, 399(7), 2503-2509 (2011-01-19)
Functionalization of the surfaces of silica particles is often the first step in their various applications. An improved heterogeneous Fmoc-Cl fluorescent assay using an aqueous solution was developed to detect the number of amino groups on solid-phase supports. The fluorescent
Päivi Uutela et al.
Analytica chimica acta, 633(2), 223-231 (2009-01-27)
The efficiencies of three derivatisation reagents that react with either the amine (9-fluorenylmethyl chloroformate (FMOC)) or the carboxylic acid group (butanol) of amino acid or with both types of functional groups (propyl chloroformate) were compared in the analysis of amino
Sary El Daker et al.
PloS one, 10(4), e0123772-e0123772 (2015-04-17)
Tuberculosis (TB) is still the principal cause of death caused by a single infectious agent, and the balance between the bacillus and host defense mechanisms reflects the different manifestations of the pathology. The aim of this work was to study
Qiong-Hui Zou et al.
Journal of separation science, 30(16), 2647-2655 (2007-09-18)
A novel approach for simultaneous determination of 12 sulphonamides (sulphadiazine, sulphamethazine, sulphathiazole, sulphadimethoxine, sulphamerazine, sulphapyridine, sulphamethoxazole, suphamethizole, sulphaquinoxaline, sulphameter, sulphamonomethoxine, and sulphachloropyridazine) in animal tissues (swine muscle and liver, chicken muscle, beef muscle) by HPLC with UV detection has been
Hamed Gilzad Kohan et al.
PloS one, 10(5), e0126786-e0126786 (2015-05-16)
The aim of this study was to synthesize a peptide prodrug of glucosamine (GlcN) with increased gut permeability through the gut peptide transporter 1 (PepT1). Glycine-Valine ester derivative of GlcN (GVG) was synthesised using solid phase synthesis followed by characterization
Jae Hyun Kim et al.
Nanomaterials (Basel, Switzerland), 11(1) (2020-12-31)
Here, we report a post-synthesis functionalization of the shell of Au nanoclusters (NCs) synthesized using glutathione as a thiolate ligand. The as-synthesized Au NCs are subjected to the post-synthesis functionalization via amidic coupling of dopamine on the cluster shell to
Shengyuan Xiao et al.
Analytical biochemistry, 384(1), 20-26 (2008-10-11)
Methylamine and aminoacetone are endogenous aliphatic amines found in human blood and urine. They can be oxidized by semicarbazide-sensitive amine oxidase (SSAO), leading to the production of toxic aldehydes such as formaldehyde and methylglyoxal as well as hydrogen peroxide and
Kun Qian et al.
Analytica chimica acta, 635(2), 222-226 (2009-02-17)
A pre-column derivatization high-performance liquid chromatographic method for glyphosate analysis has been developed. Derivatization of glyphosate was performed with 4-chloro-3,5-dinitrobenzotrifluoride (CNBF). In pH 9.5 H(3)BO(3)-Na(2)B(4)O(7) media, the reaction of glyphosate with CNBF completed at 60 degrees C for 30min. The
Ying Liu et al.
Journal of chromatographic science, 47(10), 925-930 (2009-11-26)
A sensitive and reliable method has been developed to determine synephrine in a famous purgative Chinese medicinal prescription, da-cheng-qi decoction. After purified by solid-phase extraction (SPE), the decoction was derivatized with 9-fluorenylmethyl chloroformate in borate buffer and analyzed by reversed-phase
Bart Hens et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 233-242 (2014-07-30)
The purpose of this study was to explore the transfer of drug solutions from stomach to small intestine and its impact on intraluminal drug concentrations in humans. The collected intraluminal data were used as reference to evaluate simulations of gastrointestinal
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