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Jie Xing et al.
Journal of cellular biochemistry, 120(6), 10145-10154 (2018-12-15)
The aim of this study is to evaluate the effects of microRNA-183 (miRNA-183) in myocardial damager. In the cell experiment, the H9C2 cell was divided into three groups: NC group, Model group, and miRNA group. The cell apoptosis and relative
Sidharth Razdan et al.
Scientific reports, 9(1), 8867-8867 (2019-06-22)
The presence of endotoxin, also known as lipopolysaccharides (LPS), as a side product appears to be a major drawback for the production of certain biomolecules that are essential for research, pharmaceutical, and industrial applications. In the biotechnology industry, gram-negative bacteria
Wan-Ting Hung et al.
The European journal of neuroscience, 52(12), 4890-4907 (2020-07-09)
The cellular and molecular mechanisms underlying leptin-mediated brain protection against cerebral ischemia were investigated at the blood-brain barrier (BBB) and neutrophil level. Through the ischemia/reperfusion (I/R) animal model, we found that leptin expression level was significantly decreased in ischemic hemisphere.
Jingjing Lu et al.
Life sciences, 260, 118305-118305 (2020-08-23)
The study aims to investigate the roles of LncRNA and miRNA in ferroptosis in brain ischemia/reperfusion (I/R) in vivo and in vitro. qPCR assay was used to analyze lncRNA PVT1 and miR-214 expressions in acute ischemic stroke (AIS) patients. Then
Gehan H Heeba et al.
Life sciences, 90(11-12), 388-395 (2012-01-10)
Oxidative stress-induced cell damage is reported to contribute to the pathogenesis of cerebral ischemia/reperfusion injury. This study investigated the neuroprotective effect of nebivolol against cerebral ischemia/reperfusion insult in rats. The model adopted was that of surgically-induced forebrain ischemia, performed by
Anjing Zhang et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 39(5), 613-618 (2012-08-31)
The current study explored the effects of treadmill exercise intensity on functional recovery and hippocampal phospho-NR2B (p-NR2B) expression in cerebral ischemic rats, induced by permanent middle cerebral artery occlusion (MCAO) surgery. Adult male Sprague-Dawley rats were randomly divided into four
Suning Ping et al.
Aging and disease, 12(1), 72-92 (2021-02-04)
Chemokine (C-C motif) receptor 5 (CCR5) is expressed not only in the immune cells but also in cerebral cells such as neurons, glia, and vascular cells. Stroke triggers high expression of CCR5 in the brain. However, the role of CCR5
O Kenny et al.
Food chemistry, 161, 79-86 (2014-05-20)
Antimicrobial properties of ethanol and water extracts from eight Asteraceae species were investigated against three Gram positive (Staphylococcus aureus, MRSA and Bacillus cereus) and two Gram negative (Escherichia coli and Salmonella typhimurium) bacterial strains. Ethanol extracts from Centaurea scabiosa, Arctium
Ratchanee Kongkachuichai et al.
Food chemistry, 173, 838-846 (2014-12-04)
Evidence from epidemiological studies has strongly suggested that diets rich in fruits and vegetables play a vital role in disease prevention. The aim of this study was to determine nutrient and antioxidant content for 15 varieties of indigenous vegetables and
Silvia Ruiz-Crespo et al.
Metabolic brain disease, 28(1), 21-24 (2012-11-20)
Biochemical and metabolic analysis of ischemic cerebral tissue is central in stroke investigation and is usually performed in animal stroke models, such as the permanent occlusion of the middle cerebral artery (MCAO) in the rat that we have used. To
Hui Ji et al.
Neuroscience letters, 506(1), 1-6 (2011-12-03)
Oxidative and cytotoxic damage play an important role in cerebral ischemic pathogenesis and may represent a target for treatment. Recent studies have indicated that sonic hedgehog (Shh) signaling could protect neurons against oxidative stress by increasing superoxide dismutase 1 (SOD1)
Roya Hosseini et al.
Iranian journal of pharmaceutical research : IJPR, 19(2), 98-114 (2020-11-24)
One of the newest methods to reduce cerebral ischemia damages is cell therapy. The aim of this study is to evaluate the effect of Sertoli cell transplantation on ischemia-induced injuries in animal models of stroke. Rats were divided into four
Junyi Shen et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 192-200 (2019-01-22)
After cerebral infarction, the regeneration of microvascular played an important role in the recovery. Ginsenoside Rg1 (Rg1) had good effects on promoting angiogenesis and neuro-protection in cerebral infarction treatment. However, the blood-brain barrier (BBB) restricted Rg1 to enter into cerebral
Mei Yang et al.
Food chemistry, 177, 304-312 (2015-02-11)
It has been claimed that consumptions of Abrus cantoniensis (AC) and Abrus mollis (AM) as folk beverages and soups are good to cleanse liver toxicants and prevent liver diseases. There is scant information on the phytochemical profiles and antioxidant activities
Sunan Wang et al.
Journal of medicinal food, 18(3), 345-353 (2014-10-15)
Previous works on staghorn sumac (Rhus hirta) were mostly dedicated to its phytochemical profiles, antioxidant properties, and antidiabetic potentials. This study explored the potential of staghorn-sumac-derived functional ingredients for food and pharmacological applications. Sumac may have other biological functions, such
Aseesh Pandey et al.
Molecular biology reports, 46(2), 2231-2241 (2019-02-14)
Efficient micropropagation procedure was developed for Origanum vulgare, a high-value culinary herb, and the phytochemicals, phenolic content, antioxidant and antimutagenic activity of leaf and stem, derived from different growing stages were analyzed. The agar solidified Murashige and Skoog (MS) medium
John Thundyil et al.
PloS one, 8(1), e53528-e53528 (2013-01-12)
Ephrin (Eph) signaling within the central nervous system is known to modulate axon guidance, synaptic plasticity, and to promote long-term potentiation. We investigated the potential involvement of EphA2 receptors in ischemic stroke-induced brain inflammation in a mouse model of focal
Yao Tang et al.
Food chemistry, 174, 502-508 (2014-12-23)
Composition of fatty acids, tocopherols, tocotrienols, and carotenoids, and their contribution to antioxidant activities were investigated in seeds of three coloured quinoa cultivars (white, red and black). The major components and individual compounds were significantly different, and their concentrations were
Ruiqing Ni et al.
Neurophotonics, 5(1), 015005-015005 (2018-03-14)
Oxygen metabolism and matrix metalloproteinases (MMPs) play important roles in the pathophysiology of cerebral ischemia. Using multispectral optoacoustic tomography (MSOT) imaging, we visualized in vivo changes in cerebral tissue oxygenation during 1 h of transient middle cerebral artery occlusion (tMCAO) and
Jingzi Beiyuan et al.
The Science of the total environment, 612, 1463-1472 (2017-09-15)
Remediation of CCA-contaminated soil (Cr, Cu, and As) by biodegradable chelant-enhanced washing (EDDS, S,S-ethylene-diamine-disuccinic-acid) needs further enhancement. This study investigated the effectiveness of coupling with pre-treatment by selective dissolution and post-treatment by soil amendments, respectively. Three groups of reagents (reductants
Xiang Hou et al.
PloS one, 9(9), e108314-e108314 (2014-10-01)
The aim of this study was to investigate the antioxidant potential of ampelopsin (APS) by using various methods in vitro, as well as to determine effects of APS on LPS-induced oxidative stress in piglets. The results showed that APS exhibited
Na Zhu et al.
Frontiers in pharmacology, 11, 367-367 (2020-04-16)
Berberine (BBR) has a variety of pharmacological activities and is widely used in Asian countries. However, the clinical application of BBR still lacks scientific basis, what protective mechanism of BBR against myocardial ischemia-reperfusion injury (MIRI). In vitro experiments, BBR pretreatment
Jin-Min Guo et al.
Cell research, 23(7), 915-930 (2013-05-22)
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an unbiased proteomic search, we identified ALDH2 deficiency in stroke-prone spontaneously hypertensive rats (SHR-SP) as compared with spontaneously hypertensive rats (SHR).
Li Li et al.
Experimental neurology, 234(1), 181-190 (2012-01-10)
Transmembrane protein 166 (TMEM166) is a lysosomal/endoplasmic reticulum-associated protein found in various species where it acts as a regulator of programmed cell death, mediating both autophagy and apoptosis. In the present study, we investigated the role of TMEM166 following MCAO
Y-box protein 1 promotes hypoxia/reoxygenation- or ischemia/reperfusion-induced cardiomyocyte apoptosis via SHP-1-dependent STAT3 inactivation.
Cao, et al.
Journal of Cellular Physiology, 235, 8187-8198 (2021)
Jun Cheng et al.
Food chemistry, 168, 90-99 (2014-08-31)
The aim of this study was to investigate the applicability of artificial neural network (ANN) and multiple linear regression (MLR) models for the estimation of acrylamide reduction by flavonoids, using multiple antioxidant capacities of Maillard reaction products as variables via
Linfeng Qian et al.
Aging, 11(15), 5368-5388 (2019-08-14)
This study is intended to figure out the function of microRNA-218 (miR-218) together with microphthalmia-associated transcription factor (MITF) on the cardiac fibrosis and cardiac function impairment in rat models of myocardial infarction (MI). The rats with MI exhibited cardiac function
Yi Li et al.
Pharmacological research, 130, 110-122 (2018-02-07)
Mitochondrial reactive oxygen species (mtROS) directly stimulate the inflammatory cytokines cascades and participate in age-related changes of cardiovascular diseases. Application of small molecule targeting the mtROS is significant towards development of better therapy to combat inflammatory response after myocardial infarction
Emilie Decaup et al.
Frontiers in immunology, 10, 1943-1943 (2019-09-03)
Follicular lymphoma (FL) is the second most frequent subtype of B non-Hodgkin's lymphomas (NHL) for which the treatment is based on the use of anti-CD20 mAbs. NK cells play a crucial role in their mechanism of action and the number
Hui Chen et al.
Applied biochemistry and biotechnology, 187(3), 677-690 (2018-07-25)
Lotus seed epicarp, a byproduct of lotus seed production process, is usually discarded as a waste. In this study, antioxidant and anti-α-amylase activities of freeze-dried water and various methanol extracts of lotus seed epicarp were evaluated. The extract obtained by
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