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Kristin Zscharnack et al.
Analytica chimica acta, 834, 51-57 (2014-06-15)
Here, we present a fast and simple hydrogen peroxide assay that is based on time-resolved fluorescence. The emission intensity of a complex consisting of terbium ions (Tb(3+)) and phthalic acid (PA) in HEPES buffer is quenched in the presence of
Akihiro Tai et al.
Bioscience, biotechnology, and biochemistry, 78(10), 1723-1730 (2014-10-03)
The antioxidative properties of ascorbigen, one of the major indole-derived compounds of Brassica vegetables, were systematically evaluated using multiple assay systems with comparison to the well-known antioxidants ascorbic acid and Trolox. We first performed assays using model radicals, DPPH radical
Amit Kumar De et al.
Journal of microencapsulation, 31(8), 725-737 (2014-06-26)
Abstract Context: Ursodeoxycholic acid (UDCA) exerts dose-dependent chemoprevention in colonic inflammation. Polycationic UDCA nanoparticles (UNPs) are envisaged for solubility enhancement and site directed drug delivery. The objective was to study the ameliorative efficacy of UNPs through localized delivery of the
Barbara Crone et al.
Metallomics : integrated biometal science, 7(7), 1189-1195 (2015-05-23)
cis-Diamminedichloroplatinum(II) (Cisplatin) is one of the most important and frequently used cytostatic drugs for the treatment of various solid tumors. Herein, a laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) method incorporating a fast and simple sample preparation protocol was developed for
Ivan V Maksymiv et al.
Pesticide biochemistry and physiology, 122, 67-75 (2015-06-15)
The effects of 96 h exposure to 7.14, 35.7, or 71.4 mg L(-1) of Sencor were studied on liver and plasma parameters in goldfish, Carassius auratus L. Goldfish exposure to 71.4 mg L(-1) of Sencor for 96 h resulted in a decrease in glucose
Soon Ok Kim et al.
Endocrinology, 155(4), 1466-1475 (2014-02-11)
Prostaglandin E2 (PGE2) is a key mediator of ovulation. All 4 PGE2 receptors (EP receptors) are expressed in the primate follicle, but the specific role of each EP receptor in ovulatory events is poorly understood. To examine the ovulatory events
Julia Thierauf et al.
Melanoma research, 25(6), 503-509 (2015-09-10)
Mucosal melanoma of the head and neck is a rare and aggressive tumor entity with a poor prognosis. The standard treatment is radical tumor resection, with or without adjuvant radiation, where conventional chemotherapies in advanced stage or recurrent diseases have
Catherine To et al.
PloS one, 9(11), e112106-e112106 (2014-11-25)
Eph and ephrin proteins are essential cell guidance cues that orchestrate cell navigation and control cell-cell interactions during developmental tissue patterning, organogenesis and vasculogenesis. They have been extensively studied in animal models of embryogenesis and adult tissue regeneration, but less
Yuan He et al.
Investigative ophthalmology & visual science, 55(10), 6742-6755 (2014-09-13)
Oxidative stress plays an important role in health and aging. We have shown that oxidative stress impairs mitochondrial function and promotes RPE cell death in an age-dependent manner. This study investigates the role of pigment epithelium-derived factor (PEDF) in limiting
Corina Danciu et al.
International journal of experimental pathology, 96(2), 73-80 (2015-02-11)
Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. The aim of this study was to explore the behaviour of four different B16 murine melanoma cell sublines after inoculation into C57BL/6J mice; and, more specifically to
Shinya Hayashi et al.
Arthritis research & therapy, 17, 314-314 (2015-11-08)
Osteoarthritis (OA) is a multifactorial disease, and recent studies have suggested that cell cycle-related proteins play a role in OA pathology. p21 was initially identified as a potent inhibitor of cell cycle progression. However, it has been proposed that p21
Frank Scalia et al.
The Journal of comparative neurology, 523(12), 1756-1791 (2014-12-17)
To provide a modern description of the Chiropteran visual system, the subcortical retinal projections were studied in the short-tailed fruit bat, Carollia perspicillata, using the anterograde transport of eye-injected cholera toxin B subunit, supplemented by the silver-impregnation of anterograde degeneration
Amin M D Shakhawat et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(41), 14070-14075 (2015-10-16)
Arc ensembles in adult rat olfactory bulb (OB) and anterior piriform cortex (PC) were assessed after discrimination training on highly similar odor pairs. Nonselective α- and β-adrenergic antagonists or saline were infused in the OB or anterior PC during training.
Chi Keung Lam et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6466-E6475 (2015-11-11)
The major underpinning of massive cell death associated with myocardial infarction involves opening of the mitochondrial permeability transition pore (mPTP), resulting in disruption of mitochondria membrane integrity and programmed necrosis. Studies in human lymphocytes suggested that the hematopoietic-substrate-1 associated protein
Justin E Mirus et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(7), 1764-1771 (2015-01-16)
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in the United States, and its incidence is on the rise. Advanced disease is nearly uniformly lethal, emphasizing the need to identify PDA at its earliest stages. To
Grazielle V B Huguenin et al.
Microcirculation (New York, N.Y. : 1994), 22(8), 687-699 (2015-07-28)
To investigate the effects of dietary supplementation with GBNs on microvascular endothelial function in hypertensive and dyslipidemic patients. Ninety-one patients of both sexes aged 62.1 ± 9.3 years received 13 g/day of GBNs or a placebo for three months with
Masahiro Sano et al.
The Journal of reproduction and development, 61(5), 439-448 (2015-07-15)
The corpus luteum (CL) is a temporary endocrine gland producing a large amount of progesterone, which is essential for the establishment and maintenance of pregnancy. Galectin-1 is a β-galactose-binding protein that can modify functions of membrane glycoproteins and is expressed
Melanie L Foster et al.
Toxicological sciences : an official journal of the Society of Toxicology, 145(2), 244-251 (2015-03-01)
Concerns exist as to whether individuals may be at greater risk for neurotoxicity following increased manganese (Mn) oral intake. The goals of this study were to determine the equivalence of 3 methods of oral exposure and the rate (mg Mn/kg/day)
Damián Dorfman et al.
PloS one, 9(7), e101829-e101829 (2014-07-09)
Diabetic retinopathy is a leading cause of reduced visual acuity and acquired blindness. Available treatments are not completely effective. We analyzed the effect of environmental enrichment on retinal damage induced by experimental diabetes in adult Wistar rats. Diabetes was induced
Lars Tomanek
The Journal of experimental biology, 218(Pt 12), 1867-1879 (2015-06-19)
Environmental (acute and chronic temperature, osmotic, hypoxic and pH) stress challenges the cellular redox balance and can lead to the increased production of reactive oxygen species (ROS). This review provides an overview of the reactions producing and scavenging ROS in
Li-Hua Mu et al.
Biological & pharmaceutical bulletin, 37(6), 1035-1041 (2014-06-03)
The aim of this study was to explore whether the ethanolic extract of Ardisia gigantifolia rhizomes (AGB-5), a traditional herbal medicine from China, could affect the proliferation of human breast adenocarcinoma (MCF-7) cells in vitro and to explore the antitumor
Yulei Wang et al.
Free radical biology & medicine, 79, 186-196 (2014-12-03)
Selenium is an essential trace element and has been extensively studied for preventive effects on cancers. Recent emerging evidence has also shown that selenium at supranutritional dosage has a preferential cytotoxicity in cancer cells and chemotherapeutic drug-resistant cells, but the
Hao Meng et al.
Acta biomaterialia, 17, 160-169 (2015-02-14)
To decouple the extracellular oxidative toxicity of catechol adhesive moiety from its intracellular non-oxidative toxicity, dopamine was chemically bound to a non-degradable polyacrylamide hydrogel through photo-initiated polymerization of dopamine methacrylamide (DMA) with acrylamide monomers. Network-bound dopamine released cytotoxic levels of
A L Anding et al.
Cell death and differentiation, 22(3), 457-464 (2014-10-25)
Autophagy is a catabolic process used to deliver cellular material to the lysosome for degradation. The core Vps34/class III phosphatidylinositol 3-kinase (PI3K) complex, consisting of Atg6, Vps15, and Vps34, is highly conserved throughout evolution, critical for recruiting autophagy-related proteins to
Macarena Munoz et al.
Chemosphere, 109, 34-41 (2014-05-31)
The application of the Fenton process for the treatment of sawmill wastewater has been investigated. The sawmill wastewater was characterized by a moderate COD load (≈3gL(-1)), high ecotoxicity (≈ 40 toxicity units) and almost negligible BOD/COD ratio (5×10(-3)) due to
Hossein Abdolmohammad-Zadeh et al.
Analytica chimica acta, 881, 54-64 (2015-06-05)
A simple dispersive solid-phase micro-extraction method based on CoFe2O4 nano-particles (NPs) functionalized with 8-hydroxyquinoline (8-HQ) with the aid of sodium dodecyl sulfate (SDS) was developed for separation of Al(III) ions from aqueous solutions. Al(III) ions are separated at pH 7
Rosalia Leonardi et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 44(10), 870-875 (2014-12-06)
Temporomandibular joint (TMJ) internal derangement (ID) is one of the most common form of temporomandibular disorders. There is evidence showing the increased expression of matrix metalloproteinases (MMPs) in the cells from degenerated TMJ disc. ADAMTS are a large family of
Taissia G Popova et al.
PloS one, 10(6), e0129860-e0129860 (2015-06-20)
Anthrax is a frequently fatal infection of many animal species and men. The causative agent Bacillus anthracis propagates through the lymphatic system of the infected host; however, the specific interactions of the host and microbe within the lymphatics are incompletely
Seydou Sylla et al.
Microbiology and immunology, 58(7), 398-408 (2014-05-23)
Post-weaning multisystemic wasting syndrome (PMWS) associated with porcine circovirus type 2 (PCV2) has caused the swine industry significant health challenges and economic damage. Although inactivated and subunit vaccines against PMWS have been used widely, so far no DNA vaccine is
Yusuke Ohara et al.
Cancer science, 104(8), 1127-1134 (2013-05-18)
CD44(+) /CD24(+) /EpCAM(+) cells have been reported to be cancer stem cells in pancreatic cancer; however, the histological and clinical importance of these cells has not yet been investigated. Here we clarified the characteristics of CD44(+) /CD24(+) /EpCAM(+) cells in
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