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Hui Liu et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt B, 483-491 (2014-09-24)
Leydig cells are the primary source of testosterone in the testes, and their steroidogenic function is strictly controlled by the hypothalamus-pituitary-gonad axis. Emerging evidence has indicated that fibroblast growth factors play a role in regulating stem Leydig cell development and
Simon Godin et al.
Journal of agricultural and food chemistry, 63(28), 6484-6492 (2015-07-15)
Two forms of selenium (Se) supplementation of fish feeds were compared in two different basal diets. A 12-week feeding trial was performed with rainbow trout fry using either a plant-based or a fish meal-based diet. Se yeast and selenite were
Francisco Javier Rodriguez-Jimenez et al.
International journal of molecular sciences, 16(11), 26608-26618 (2015-11-13)
Ion channels included in the family of Connexins (Cx) help to control cell proliferation and differentiation of neuronal progenitors. Here we explored the role of Connexin 50 (Cx50) in cell fate modulation of adult spinal cord derived neural precursors located
Fabiola Rusolo et al.
Molecules (Basel, Switzerland), 18(3), 2549-2562 (2013-02-28)
The need to explore new alternative therapeutic strategies and chemoprevention methods for hepatocellular carcinoma is growing significantly. Selenium is a trace element that plays a critical role in physiological processes, and is used in cancer chemoprevention. The aim of this
Vivek Narayan et al.
The Journal of nutritional biochemistry, 26(2), 138-145 (2014-12-03)
Acetylation of histone and non-histone proteins by histone acetyltransferases plays a pivotal role in the expression of proinflammatory genes. Given the importance of dietary selenium in mitigating inflammation, we hypothesized that selenium supplementation may regulate inflammatory gene expression at the
Lan Yang et al.
Neurochemical research, 45(8), 1888-1901 (2020-05-25)
Selenium has been shown to possess antioxidant and neuroprotective effects by modulating mitochondrial function and activating mitochondrial biogenesis. Our previous study has also suggested that selenium protected neurons against glutamate toxicity and hyperglycemia-induced damage by regulating mitochondrial fission and fusion.
Lei Rao et al.
International journal of nanomedicine, 9, 4819-4828 (2014-11-08)
As a potential protein therapeutic for type 2 diabetes mellitus (T2DM), BAY 55-9837 is limited by poor stability and a very short half-life in vivo. The purpose of this study was to construct a novel nanostructured biomaterial by conjugating BAY
Eizo Masuda et al.
BioTechniques, 58(6), 318-324 (2014-01-01)
During mammalian embryogenesis, sclerotome-derived chondrocytes in the limb bud are arranged into a complicated bone shape with specific areas undergoing hypertrophy and calcification, creating a region-specific mineralized pattern in the cartilage. To follow chondrogenesis progression in vitro, we isolated limb
María Sancho-Tello et al.
The International journal of artificial organs, 38(4), 210-223 (2015-05-09)
Tissue engineering techniques were used to study cartilage repair over a 12-month period in a rabbit model. A full-depth chondral defect along with subchondral bone injury were originated in the knee joint, where a biostable porous scaffold was implanted, synthesized
Jia Liu et al.
Molecular and cellular biochemistry, 398(1-2), 207-215 (2014-09-23)
It is well accepted that β1 integrin plays a key role in maintaining normal podocytes form and functions; however, its mechanism of the potential protective effect remains unclear. Furthermore, the investigation and understanding of the non-lipid-dependent renal protection of Statins
Hitoshi Ueno et al.
Biological & pharmaceutical bulletin, 37(8), 1352-1358 (2014-08-05)
Although supplementation with the selenocompound, sodium selenite has been shown to stimulate the concanavalin A-induced T-cell mitogenic response, the mechanisms responsible remain unclear. This study was conducted to evaluate the relationships between the induction of apoptosis, formation of tumor necrosis
C Linscheid et al.
Placenta, 36(8), 832-838 (2015-06-23)
Maternal T-cells reactive towards paternally inherited fetal minor histocompatibility antigens are expanded during pregnancy. Placental trophoblast cells express at least four fetal antigens, including human minor histocompatibility antigen 1 (HA-1). We investigated oxygen as a potential regulator of HA-1 and
Yongchao Li et al.
American journal of physiology. Cell physiology, 309(8), C532-C540 (2015-08-14)
Loss of oligodendrocytes as the result of central nervous system disease causes demyelination that impairs axon function. Effective directional migration of endogenous or grafted oligodendrocyte precursor cells (OPCs) to a lesion is crucial in the neural remyelination process. In this
Justin L Luebke et al.
Metallomics : integrated biometal science, 5(4), 335-342 (2013-02-07)
Staphylococcus aureus CstR (CsoR-like sulfur transferase repressor) is a member of the CsoR family of transition metal sensing metalloregulatory proteins. Unlike CsoR, CstR does not form a stable complex with transition metals but instead reacts with sulfite to form a
Suk Ho Bhang et al.
Biomaterials, 55, 33-43 (2015-05-03)
At high concentrations, manganese (Mn) promotes cellular neurodevelopment but causes toxicity. Here, we report that Mn ion at high concentrations can be delivered to pheochromocytoma 12 (PC12) cells using gold nanoparticles (AuNPs) to enhance cellular neurodevelopment without toxicity. Mn(2+) release
J I Eze et al.
Experimental parasitology, 135(2), 331-336 (2013-08-07)
Trypanosomosis has been associated with immunosuppression, anemia and oxidative damage while selenium possesses both immunostimulatory and antioxidative effects. This study was designed to assess the effect of dietary selenium supplementation on parasitemia, anemia, survival pattern and serum protein profiles of
Larbi Amazit et al.
The Journal of biological chemistry, 290(36), 21876-21889 (2015-07-24)
Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antagonists such as spironolactone and eplerenone are clinically useful for
H Luo et al.
Cell death & disease, 4, e481-e481 (2013-02-09)
Mounting evidence shows that selenium possesses chemotherapeutic potential against tumor cells, including leukemia, prostate cancer and colorectal cancer (CRC) cells. However, the detailed mechanism by which sodium selenite specifically kills tumor cells remains unclear. Herein, we demonstrated that supranutritional doses
A Dalle Zotte et al.
Poultry science, 94(9), 2114-2123 (2015-07-29)
This study investigated the impact of 2 coccidiosis control systems (vaccine vs anticoccidial) and 2 feeding plans (standard energy vs low energy content, the latter supplemented with threonine and enzymes in the second half of the production cycle) on white
Alexandra C Weaver et al.
Toxins, 6(12), 3336-3353 (2014-12-24)
To evaluate the effects of the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA) on pigs and the benefits of two mycotoxin mitigation strategies, gilts (n = 84, 9.1 ± 0.1 kg) were allotted to four treatments: CON (control); MT (4.8 mg/kg
Hitoshi Ueno et al.
Biological & pharmaceutical bulletin, 37(9), 1569-1574 (2014-09-02)
The effects of administering the selenocompounds, sodium selenite, methylseleninic acid (MSA), and seleno-L-methionine (SeMet) on glucose tolerance were compared in the nicotinamide (NA) and streptozotocin (STZ)-induced diabetic mouse model. ICR mice were intraperitoneally treated twice with STZ (100 mg/kg) 15 min after
Hatice Baş et al.
Environmental toxicology and pharmacology, 39(3), 1019-1026 (2015-04-12)
The adverse effects of lead nitrate (LN) and the preventive role of sodium selenite were investigated in diabetic and non-diabetic rat blood by measuring trolox equivalent antioxidant capacity (TEAC), ferric reducing antioxidant power (FRAP), malondialdehyde (MDA) levels and activities of
Ibtissem Ben Amara et al.
Environmental toxicology, 28(11), 630-643 (2011-09-03)
There is considerable interest in the study of free radical-mediated damage to biological systems due to pesticide exposure. However, there is a lack of consensus as to which determinations are best used to quantify future risks arising from xenobiotic exposure
Jianjun Hu et al.
Human molecular genetics, 23(17), 4663-4673 (2014-04-25)
Filamin B (FlnB) is an actin-binding protein thought to transduce signals from various membrane receptors and intracellular proteins onto the actin cytoskeleton. Formin1 (Fmn1) is an actin-nucleating protein, implicated in actin assembly and intracellular signaling. Human mutations in FLNB cause
Rooban B Nahomi et al.
The Biochemical journal, 465(1), 115-125 (2014-10-22)
Previous studies have identified peptides in the 'crystallin-domain' of the small heat-shock protein (sHSP) α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in heat-shock protein Hsp20 (G71HFSVLLDVKHFSPEEIAVK91) and Hsp27 (D93RWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin also have robust
Ying Yi Chen et al.
Cancer chemotherapy and pharmacology, 74(1), 25-35 (2014-05-08)
SN 28049 is a new DNA-binding topoisomerase II poison identified by its curative activity against the murine colon 38 carcinoma. Previous studies showed activity to be associated with selective drug accumulation and retention in tumour tissue. Retention varied widely among
Terry W Moody et al.
Journal of molecular neuroscience : MN, 56(3), 663-672 (2015-03-13)
Cholecystokinin (CCK) receptors are G-protein coupled receptors (GPCR) which are present on lung cancer cells. CCK-8 stimulates the proliferation of lung cancer cells, whereas the CCK2R receptor antagonist CI-988 inhibits proliferation. GPCR for some gastrointestinal hormones/neurotransmitters mediate lung cancer growth
Tao Yin et al.
PloS one, 9(12), e114581-e114581 (2014-12-19)
According to the cancer stem cells (CSCs) theory, malignant tumors may be heterogeneous in which a small population of CSCs drive the progression of cancer. Because of their intrinsic abilities, CSCs may survive a variety of treatments and then lead
Dongwook Lee et al.
Fish physiology and biochemistry, 41(6), 1569-1576 (2015-08-05)
This study was conducted to identify embryonic stem cell (ESC) activities of a long-term cultured embryonic cell line previously derived from blastula-stage Oryzias dancena embryos. Five sub-cell lines were established from the embryonic cell line via clonal expansion of single
Urška Kristan et al.
Biological trace element research, 151(2), 240-246 (2012-12-18)
The distribution and speciation of selenium (Se) in freshwater fish (muscle and liver tissue) from lakes in Argentina was investigated. Three introduced species, brown trout (Salmo trutta), rainbow trout (Oncorhynchus mykiss) and brook trout (Salvelinus fontinalis), and one native species
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