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Tatjana Orct et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 28(4), 701-712 (2015-05-08)
Detoxification of mercury (Hg) with selenium (Se) in the early postnatal period with regard to the expression of metallothionein protein (MT), essential element status, and lipid peroxidation level in tissues has not been studied. Seven-day-old Wistar pups were orally pretreated...
Hong Gao et al.
Environmental toxicology and pharmacology, 37(3), 1079-1089 (2014-05-02)
The aim of this work was to investigate genomic DNA damage in human oral cavity cells after exposure to different tobacco product preparations (TPPs). The oral carcinoma cell line 101A, gingival epithelial cells HGEC, and gingival fibroblasts HGF were exposed...
Youbin Liu et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(5), 1986-1998 (2015-04-15)
Urothelial carcinoma-associated 1 (UCA1) is a recently identified long non coding RNA (lncRNA). However, few studies have explored its role in cardiomyocytes after focal cardiac ischemia reperfusion injury (CIR). Rat CIR models were established using ligation of the Lower Anterior...
Eva Vergaño-Vera et al.
Developmental neurobiology, 75(8), 823-841 (2014-12-03)
The transcription factor Nurr1 is expressed in the mouse olfactory bulb (OB), although it remains unknown whether it influences the generation of dopaminergic neurons (DA) (DA neurons) in cells isolated from this brain region. We found that expressing Nurr1 in...
Ulrike Fischer et al.
Oncotarget, 6(9), 7023-7039 (2015-03-12)
In development of amphibians and flies, gene amplification is one of mechanisms to increase gene expression. In mammalian cells, gene amplification seems to be restricted to tumorigenesis and acquiring of drug-resistance in cancer cells. Here, we report a complex gene...
Valerie L Flax et al.
The American journal of clinical nutrition, 99(4), 950-956 (2014-02-07)
Selenium is found in soils and is essential for human antioxidant defense and immune function. In Malawi, low soil selenium and dietary intakes coupled with low plasma selenium concentrations in HIV infection could have negative consequences for the health of...
Simon P W Hageman et al.
Water research, 47(7), 2118-2128 (2013-03-15)
Removal of the toxic selenium compounds selenite and selenate from waste water before discharge is becoming increasingly imperative in industrialized countries. Bacteria can reduce selenate to selenite, but also further to elemental selenium, selenide or organic selenium. In this paper...
Hina Mir et al.
Oncotarget, 6(12), 9985-9998 (2015-04-19)
Lung cancer (LuCa) is the leading cause of cancer-related deaths worldwide regardless of the gender. High mortality associated with LuCa is due to metastasis, molecular mechanisms of which are yet to be defined. Here, we present evidence that chemokine receptor...
Y Ci et al.
Cell death & disease, 5, e1542-e1542 (2014-11-28)
Reactive oxygen species (ROS) have an important role in regulating various cellular processes. Our previous study confirmed that selenite, an anti-tumour agent, triggered apoptosis through the production of ROS in multiple types of cancer cells. In this study, we discovered...
Kun Wang et al.
Nature communications, 6, 7619-7619 (2015-07-18)
Mitochondrial fragmentation plays an important role in the progression of cardiac diseases, such as myocardial infarction and heart failure. Mitochondrial network is controlled by many factors in different cell types. Here we show that the interplay between E2F1, miR-421 and...
Young-Hoon Kim et al.
Nature communications, 6, 7451-7451 (2015-06-17)
Group O D-negative blood cells are universal donors in transfusion medicine and methods for converting other blood groups into this universal donor group have been researched. However, conversion of D-positive cells into D-negative is yet to be achieved, although conversion...
Zhu-Xu Zhang et al.
Transplantation, 99(5), 916-924 (2015-02-27)
Chronic allograft injury remains the leading cause of late kidney graft loss despite improvements in immunosuppressive drugs and a reduction in acute T cell-mediated rejection. We have recently demonstrated that natural killer (NK) cells are cytotoxic to tubular epithelial cells...
Kang Sun et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 52, 36-41 (2012-11-10)
Selenium, an essential trace element, can also be toxic at higher levels of exposure. Several lines of evidence show epigallocatechin-3-gallate (EGCG), a predominant component of green tea catechins with numerous health benefits, can ameliorate the toxicity of many agents. A...
Nikolce Gjorevski et al.
Scientific reports, 5, 11458-11458 (2015-07-15)
Collective cell migration drives tissue remodeling during development, wound repair, and metastatic invasion. The physical mechanisms by which cells move cohesively through dense three-dimensional (3D) extracellular matrix (ECM) remain incompletely understood. Here, we show directly that migration of multicellular cohorts...
Catarina Galinha et al.
Journal of food science and technology, 52(7), 4236-4245 (2015-07-04)
Agronomic biofortification of staple crops is an effective way to enhance their contents in essential nutrients up the food chain, with a view to correcting for their deficiencies in animal or human status. Selenium (Se) is one such case, for...
Celine Thiry et al.
Biological trace element research, 152(1), 152-160 (2013-02-12)
Most European people have selenium (Se) intake inferior to recommended values that are considered necessary to ensure the beneficial action of antioxidant selenoproteins. People could therefore tend to have recourse to Se-enriched food supplements (FS) aiming to increase their Se...
Kenjiro Bandow et al.
Bone, 74, 125-133 (2014-12-17)
Chondrocytes are derived from mesenchymal stem cells, and play an important role in cartilage formation. Sex determining region Y box (Sox) family transcription factors are essential for chondrogenic differentiation, whereas the intracellular signal pathways of Sox activation have not been...
Kun Wang et al.
Nature communications, 6, 6779-6779 (2015-04-11)
The abnormal autophagy is associated with a variety of cardiovascular diseases. Long noncoding RNAs (lncRNAs) are emerging as new factors in gene regulation, but how lncRNAs operate in the regulation of autophagy in the heart is unclear. Here we report...
Maria Teresa Dell'Anno et al.
The Journal of clinical investigation, 124(7), 3215-3229 (2014-06-18)
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional...
Ibtissem Ben Amara et al.
Environmental toxicology, 28(11), 630-643 (2011-09-03)
There is considerable interest in the study of free radical-mediated damage to biological systems due to pesticide exposure. However, there is a lack of consensus as to which determinations are best used to quantify future risks arising from xenobiotic exposure...
Jianjun Hu et al.
Human molecular genetics, 23(17), 4663-4673 (2014-04-25)
Filamin B (FlnB) is an actin-binding protein thought to transduce signals from various membrane receptors and intracellular proteins onto the actin cytoskeleton. Formin1 (Fmn1) is an actin-nucleating protein, implicated in actin assembly and intracellular signaling. Human mutations in FLNB cause...
Vivek Narayan et al.
The Journal of nutritional biochemistry, 26(2), 138-145 (2014-12-03)
Acetylation of histone and non-histone proteins by histone acetyltransferases plays a pivotal role in the expression of proinflammatory genes. Given the importance of dietary selenium in mitigating inflammation, we hypothesized that selenium supplementation may regulate inflammatory gene expression at the...
Lan Yang et al.
Neurochemical research, 45(8), 1888-1901 (2020-05-25)
Selenium has been shown to possess antioxidant and neuroprotective effects by modulating mitochondrial function and activating mitochondrial biogenesis. Our previous study has also suggested that selenium protected neurons against glutamate toxicity and hyperglycemia-induced damage by regulating mitochondrial fission and fusion....
Larbi Amazit et al.
The Journal of biological chemistry, 290(36), 21876-21889 (2015-07-24)
Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antagonists such as spironolactone and eplerenone are clinically useful for...
Jia Liu et al.
Molecular and cellular biochemistry, 398(1-2), 207-215 (2014-09-23)
It is well accepted that β1 integrin plays a key role in maintaining normal podocytes form and functions; however, its mechanism of the potential protective effect remains unclear. Furthermore, the investigation and understanding of the non-lipid-dependent renal protection of Statins...
Yongchao Li et al.
American journal of physiology. Cell physiology, 309(8), C532-C540 (2015-08-14)
Loss of oligodendrocytes as the result of central nervous system disease causes demyelination that impairs axon function. Effective directional migration of endogenous or grafted oligodendrocyte precursor cells (OPCs) to a lesion is crucial in the neural remyelination process. In this...
Rooban B Nahomi et al.
The Biochemical journal, 465(1), 115-125 (2014-10-22)
Previous studies have identified peptides in the 'crystallin-domain' of the small heat-shock protein (sHSP) α-crystallin with chaperone and anti-apoptotic activities. We found that peptides in heat-shock protein Hsp20 (G71HFSVLLDVKHFSPEEIAVK91) and Hsp27 (D93RWRVSLDVNHFAPDELTVK113) with sequence homology to α-crystallin also have robust...
Eizo Masuda et al.
BioTechniques, 58(6), 318-324 (2014-01-01)
During mammalian embryogenesis, sclerotome-derived chondrocytes in the limb bud are arranged into a complicated bone shape with specific areas undergoing hypertrophy and calcification, creating a region-specific mineralized pattern in the cartilage. To follow chondrogenesis progression in vitro, we isolated limb...
Ying Yi Chen et al.
Cancer chemotherapy and pharmacology, 74(1), 25-35 (2014-05-08)
SN 28049 is a new DNA-binding topoisomerase II poison identified by its curative activity against the murine colon 38 carcinoma. Previous studies showed activity to be associated with selective drug accumulation and retention in tumour tissue. Retention varied widely among...
A Dalle Zotte et al.
Poultry science, 94(9), 2114-2123 (2015-07-29)
This study investigated the impact of 2 coccidiosis control systems (vaccine vs anticoccidial) and 2 feeding plans (standard energy vs low energy content, the latter supplemented with threonine and enzymes in the second half of the production cycle) on white...
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