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Vincent Van Waes et al.
Neuropharmacology, 89, 77-86 (2014-09-15)
Drug combinations that include the psychostimulant methylphenidate plus a selective serotonin reuptake inhibitor (SSRI) such as fluoxetine are increasingly used in children and adolescents. For example, this combination is indicated in the treatment of attention-deficit/hyperactivity disorder and depression comorbidity and
Alexander Drobyshevsky et al.
Journal of magnetic resonance imaging : JMRI, 42(3), 666-672 (2015-04-10)
To validate DCE MRI method of placental perfusion estimation and to demonstrate application of the method in a rabbit model of fetal antenatal hypoxia-ischemia. Placental perfusion was estimated by dynamic contrast imaging with bolus injection of Gd-DTPA in 3 Tesla
I Yamamoto et al.
Journal of nutritional science and vitaminology, Spec No, 161-164 (1992-01-01)
AA-2G is a new stable derivative of AsA which is efficiently synthesized by regioselective transglucosylation with alpha-glucosidase and CGTase. AA-2G serves as a vitamin C supplement in experimental animals. AA-2G is easily hydrolyzed in vivo by alpha-glucosidase and also synthesized
Yi Zeng et al.
Biosensors & bioelectronics, 66, 55-61 (2014-12-03)
A sequential 'on/off' dual mode SERS assay platform for heparin with wider detection window and higher reliability is constructed based on electrostatic forces, in which the highly protonated chitosan encapsulated p-Mercaptobenzoic acid coated Au@Ag core-shell nanoparticles undergo sequential aggregation/segregation upon
Gyuman Park et al.
Biomaterials, 54, 201-212 (2015-04-25)
The possibility of controlling cell fates by overexpressing specific transcription factors has led to numerous studies in stem cell research. Small molecules can be used, instead of transcription factors, to induce the de-differentiation of somatic cells or to induce pluripotent
Yu-Juei Hsu et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(1), 116-127 (2014-07-06)
Inactivation of the thiazide-sensitive sodium chloride cotransporter (NCC) due to genetic mutations in Gitelman's syndrome (GS) or pharmacological inhibition with thiazide diuretics causes hypocalciuria and increased bone mineral density (BMD) with unclear extrarenal calcium (Ca(2+) ) regulation. We investigated intestinal
Madelyne M Cosme et al.
General and comparative endocrinology, 219, 89-101 (2015-02-04)
This study determined the effects of the estrogen receptor agonist ethinylestradiol (EE2) and the phospholipase A2 inhibitor quinacrine (QUIN) on the pathways controlling follicular development, steroidogenesis, oocyte maturation, ovulation and spawning success in adult zebrafish. Both EE2 and QUIN inhibited
Yongjun Wang et al.
Journal of cardiovascular pharmacology, 66(1), 63-71 (2015-03-26)
Osteoblast differentiation of valve interstitial cells (VICs) is a key step in valve calcification, but the molecular mechanisms involved are not fully understood. In this study, we aimed to investigate whether microRNA (miR)-204-regulated VICs differentiation through modulation of runt-related transcription
Christopher Grunseich et al.
Neurobiology of disease, 70, 12-20 (2014-06-14)
Spinal and bulbar muscular atrophy (SBMA, Kennedy's disease) is a motor neuron disease caused by polyglutamine repeat expansion in the androgen receptor. Although degeneration occurs in the spinal cord and muscle, the exact mechanism is not clear. Induced pluripotent stem
Javed Sheikh et al.
European journal of medicinal chemistry, 46(4), 1390-1399 (2011-02-23)
This research communication is toward the investigation of the antibacterial, antifungal and antioxidant activities of the synthesized compounds 1-(4'-O-β-D-glucopyranosyloxy-2'-hydroxyphenyl)-3-aryl-propane-1,3-diones (5a)-(5h). These compounds have been obtained by the interaction of α-acetobromoglucose with 1-(2',4'-dihydroxyphenyl)-3-aryl-propane-1,3-diones (3a)-(3h) under anhydrous condition and at lower temperature.
Chao Liu et al.
Biochemical and biophysical research communications, 452(4), 895-900 (2014-09-15)
Directed neural differentiation of human embryonic stem cells (ESCs) enables researchers to generate diverse neuronal populations for human neural development study and cell replacement therapy. To realize this potential, it is critical to precisely understand the role of various endogenous
Lucas Felipe de Oliveira et al.
Stem cells international, 2015, 685383-685383 (2015-08-25)
Systemic arterial hypertension (SAH), a clinical syndrome characterized by persistent elevation of arterial pressure, is often associated with abnormalities such as microvascular rarefaction, defective angiogenesis, and endothelial dysfunction. Mesenchymal stem cells (MSCs), which normally induce angiogenesis and improve endothelial function
Sara M Long et al.
Aquatic toxicology (Amsterdam, Netherlands), 162, 54-65 (2015-03-18)
Measuring biological responses in resident biota is a commonly used approach to monitoring polluted habitats. The challenge is to choose sensitive and, ideally, stressor-specific endpoints that reflect the responses of the ecosystem. Metabolomics is a potentially useful approach for identifying
Ming Yuan et al.
Cardiology, 131(1), 1-12 (2015-04-01)
High levels of soluble CD40 ligand (sCD40L) in the circulation have been suggested as an important indicator of cardiovascular diseases such as atherosclerosis and acute coronary syndromes. In the present study, we explored the role of sCD40L in the formation
Nao Suzuki et al.
Human reproduction (Oxford, England), 30(3), 608-615 (2015-01-09)
Is ovarian tissue cryopreservation using vitrification followed by in vitro activation (IVA) of dormant follicles a potential approach for infertility treatment of patients with primary ovarian insufficiency (POI)? Our vitrification approach followed by IVA treatment is a potential infertility therapy
Denis Fourches et al.
Chemical research in toxicology, 23(1), 171-183 (2009-12-18)
Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this
Shumin Lan et al.
Acta pharmaceutica (Zagreb, Croatia), 64(3), 369-378 (2014-10-10)
The aim of the present study was to determine the antioxidant activity of Coreopsis tinctoria flowering tops (CTFT). Studies were conducted to obtain suitable extraction conditions for chlorogenic acid, quercetin, luteolin, apigenin and kaempferol, which were identified and quantified by
E Kleszczewska
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 8(45), 155-158 (2000-06-28)
There is growing interest in the role of vitamin C physiological role. In this paper L-ascorbic acid is discussed in detail, including its physical properties, chemical activity and biological properties. The primary goal of this review is to present the
Patrick I Ferrell et al.
Stem cells (Dayton, Ohio), 33(4), 1130-1141 (2014-12-30)
Derivation of hematopoietic stem cells (HSCs) from human pluripotent stem cells remains a key goal for the fields of developmental biology and regenerative medicine. Here, we use a novel genetic reporter system to prospectively identify and isolate early hematopoietic cells
Mareike Hildegard Müller et al.
Chronobiology international, 32(1), 27-36 (2014-08-21)
The circadian clock of man and mammals shows a hierarchic organization. The master clock, located in the suprachiasmatic nuclei (SCN), controls peripheral oscillators distributed throughout the body. Rhythm generation depends on molecular clockworks based on transcriptional/translational interaction of clock genes.
Indira Prasadam et al.
Rheumatology (Oxford, England), 53(12), 2280-2287 (2014-07-06)
The aim of this study was to test the possible involvement, relevance and significance of dentin matrix protein 1 (DMP1) in chondrocyte redifferentiation and OA. To examine the function of DMP1 in vitro, bone marrow stromal cells (BMSCs) and articular
David J Burke et al.
International journal of molecular sciences, 16(10), 23630-23650 (2015-10-09)
In this study, we investigated the effect of positively and negatively charged Fe₃O₄ and TiO₂ nanoparticles (NPs) on the growth of soybean plants (Glycine max.) and their root associated soil microbes. Soybean plants were grown in a greenhouse for six
Cheng-Yi Chen et al.
Biology of reproduction, 93(4), 103-103 (2015-09-12)
We studied the smooth muscle cell differentiation capability of human placental multipotent mesenchymal stromal cells (hPMSCs) and identified how endothelial cells recruit hPMSCs participating in vessel formation. hPMSCs from term placentas were induced to differentiate into smooth muscle cells under
J C Silva et al.
Journal of cellular biochemistry, 116(8), 1658-1667 (2015-02-24)
Diabetes mellitus encompasses a group of metabolic conditions embracing the dysfunction and failure of various tissues and organs, including bone. Sustained bone alterations seem to result from anabolic, rather than catabolic processes, and suggest a decreased osteoblastic recruitment and activity.
Priyanka R Chaudhary et al.
Food chemistry, 188, 77-83 (2015-06-05)
In the current study, we examined the effects of postharvest degreening and storage on phytochemicals in Rio Red grapefruit. Grapefruits were degreened with 3.5 μl/l of ethylene at 21 °C and 80% relative humidity for 72 h, while non-degreened fruits
Wei Xie et al.
Nature communications, 6, 7570-7570 (2015-07-04)
Noble metals are important photocatalysts due to their ability to convert light into chemical energy. Hot electrons, generated via the non-radiative decay of localized surface plasmons, can be transferred to reactants on the metal surface. Unfortunately, the number of hot
Ning Xia et al.
Analytica chimica acta, 878, 95-101 (2015-05-24)
MicroRNAs (MiRNAs) have been regarded as clinically important biomarkers and drug discovery targets. In this work, we reported a simple and ultrasensitive electrochemical method for miRNAs detection based on single enzyme amplification and electrochemical-chemical-chemical (ECC) redox cycling. Specifically, upon contact
Victoria Osorio et al.
Journal of chromatography. A, 1347, 63-71 (2014-05-20)
An analytical method was developed and validated for the first determination of five major human metabolites of the non-steroidal anti-inflammatory drug diclofenac as well as two microbial transformation products in wastewater. The method was based on the extraction of diclofenac
Omar M Young et al.
American journal of reproductive immunology (New York, N.Y. : 1989), 73(1), 22-35 (2014-10-28)
Microbial-driven responses in placenta are linked with adverse pregnancy outcomes. The role of Toll-like receptor (TLR) function in Hofbauer cells (HBCs) and fetal macrophages of the placental villous core remains understudied. Flow cytometry and immunohistochemistry (IHC) were used to establish
Marta N Sanz-Ortiz et al.
ACS nano, 9(10), 10489-10497 (2015-09-16)
Noble metal nanoparticles are widely used as probes or substrates for surface enhanced Raman scattering (SERS), due to their characteristic plasmon resonances in the visible and near-IR spectral ranges. Aiming at obtaining a versatile system with high SERS performance, we
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