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Nicholas J Schaub et al.
PloS one, 10(9), e0136780-e0136780 (2015-09-05)
The surface of aligned, electrospun poly-L-lactic acid (PLLA) fibers was chemically modified to determine if surface chemistry and hydrophilicity could improve neurite extension from chick dorsal root ganglia. Specifically, diethylenetriamine (DTA, for amine functionalization), 2-(2-aminoethoxy)ethanol (AEO, for alcohol functionalization), or
Zhou Peng et al.
Journal of the American Society for Mass Spectrometry, 26(10), 1686-1694 (2015-07-01)
Gas-phase amidation of carboxylic acids in multiply-charged peptides is demonstrated via ion/ion reactions with Woodward's reagent K (wrk) in both positive and negative mode. Woodward's reagent K, N-ethyl-3-phenylisoxazolium-3'-sulfonate, is a commonly used reagent that activates carboxylates to form amide bonds
M Dinarvand et al.
International journal of biological macromolecules, 78, 112-121 (2015-04-11)
An oral delivery system intended for treatment of colon cancer in HT29 cancerous cells was investigated by encapsulating hSET1 antisense and SN38 anticancer in nanoparticles based on cysteine trimethyl chitosan (cysTMC) and carboxymethyl dextran (CMD). Studies have shown hSET1 as
Anthony S Danko et al.
New biotechnology, 30(1), 39-43 (2012-05-23)
The ability of pentane, benzene, and toluene to support aerobic cometabolism of ethylene dibromide (1,2-dibromoethane, EDB) was evaluated. A pentane enrichment culture cometabolized EDB, with a transformation capacity of 0.35 μmol EDB/mg biomass (66.2 μg EDB/mg biomass) in the absence
Rongqiang Liao et al.
Chembiochem : a European journal of chemical biology, 16(11), 1622-1628 (2015-06-03)
A targeting gene carrier for cancer-specific delivery was successfully developed through a "multilayer bricks-mortar" strategy. The gene carrier was composed of adamantane-functionalized folic acid (FA-AD), an adamantane-functionalized poly(ethylene glycol) derivative (PEG-AD), and β-cyclodextrin-grafted low-molecular-weight branched polyethylenimine (PEI-CD). Carriers produced by
Rong Yu et al.
Applied and environmental microbiology, 79(4), 1359-1367 (2012-12-25)
1,2-Dichloroethane (1,2-DCA) and 1,2-dibromoethane (ethylene dibromide [EDB]) contaminate groundwater at many hazardous waste sites. The objectives of this study were to measure yields, maximum specific growth rates (μ), and half-saturation coefficients (K(S)) in enrichment cultures that use 1,2-DCA and EDB
Peter S Toth et al.
The Analyst, 140(6), 1947-1954 (2015-02-11)
Two-phase voltammetry has been carried out using a reverse cell configuration, i.e. with the lower density organic solvent on the top of the aqueous solution in the cell, where the organic solvents contain either nitrile or ketone functional groups. The
Changkun Liu et al.
International journal of biological macromolecules, 78, 189-194 (2015-04-08)
The acetylsalicylic acid-acylated chitosan (ASACTS) with high degree of substitution (DS) was successfully synthesized, and characterized with FTIR, (1)H NMR and elemental analysis methods. The optimum synthesis conditions were obtained which gave the highest DS (about 60%) for ASACTS. Its
In Kap Ko et al.
Biomaterials, 40, 72-79 (2014-12-01)
Donor shortage remains a continued challenge in liver transplantation. Recent advances in tissue engineering have provided the possibility of creating functional liver tissues as an alternative to donor organ transplantation. Small bioengineered liver constructs have been developed, however a major
Ling Zhang et al.
Biosensors & bioelectronics, 74, 924-930 (2015-08-11)
In this work, a new manganese ions doped zinc oxide porous six arrises column nanorods was rapidly synthesized with L-Lys as the precipitating and capping agent (L-Lys/Mn-ZnONRs). The as-synthesized L-Lys/Mn-ZnONRs exhibited large specific surface area and high ferromagnetism, which could
Xiaojun Zhou et al.
ACS applied materials & interfaces, 7(29), 15777-15789 (2015-07-03)
Bone morphogenetic protein-2 (BMP-2), a growth factor that induces osteoblast differentiation and promotes bone regeneration, has been extensively investigated in bone tissue engineering. The peptides of bioactive domains, corresponding to residues 73-92 of BMP-2 become an alternative to reduce adverse
Rajan Swami et al.
International journal of pharmaceutics, 486(1-2), 287-296 (2015-04-04)
Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted drugs.
B P Antunes et al.
Carbohydrate polymers, 130, 104-112 (2015-06-17)
Frequently, skin is subjected to damaging events, such as deep cuts, burns or ulcers, which may compromise the integrity of this organ. To overcome such lesions, different strategies have been employed. Among them, wound dressings aimed to re-establish skin native
Label free aptasensor for Lysozyme detection: A comparison of the analytical performance of two aptamers.
Cristina Ocaña et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 72-77 (2015-05-27)
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 20, 429-448 (1979-10-01)
Jiadi Sun et al.
Biosensors & bioelectronics, 70, 239-245 (2015-04-02)
A novel DNA sensor for the detection of the Escherichia coli O157:H7 (E. coli O157:H7) eaeA gene was constructed using surface enhanced fluorescence (SEF). The spacing distance dependence nature of Au@Ag nanorods surface enhanced fluorescence was investigated when the cy3-labled
Ting Zhang et al.
Nanotechnology, 26(14), 145101-145101 (2015-03-17)
Based on the complementary effects of doxorubicin (DOX), all-trans retinoic acid (ATRA) and low molecular weight heparin (LMWH), the combination therapy of DOX, ATRA and LMWH was expected to exert the enhanced anti-tumor effects and reduce the side effects. In
D Belletti et al.
International journal of pharmaceutics, 490(1-2), 85-93 (2015-05-20)
In this investigation, Nutlin-3 (Nut3), a novel antitumor drug with low water solubility (<0.1mg/L at 25°C), was loaded into liposomes (Lipo-Nut3), polymeric nanoparticles (NPs-Nut3) and nanoparticles engineered with an antibody direct against Syndecan-1/CD 138 (Syn-NPs-Nut3) to obtain carriers targeted to
Raghuraj S Chouhan et al.
Biosensors & bioelectronics, 69, 26-33 (2015-02-24)
In this study, we surface engineered living S. cerevisiae cells by decorating quantum dots (QDs) and traced the fate of QDs on molecular landscape of single mother cell through several generation times (progeny cells). The fate of QDs on cell-surface
Zhengze Yu et al.
ACS nano, 9(11), 11064-11074 (2015-10-13)
Photodynamic therapy (PDT) is a well-established modality for cancer therapy, which locally kills cancer cells when light irradiates a photosensitizer. However, conventional PDT is often limited by the extremely short lifespan and severely limited diffusion distance of reactive oxygen species
Samira Hosseini et al.
Biosensors & bioelectronics, 69, 257-264 (2015-03-15)
Electrospun polyhydroxybutyrate (PHB) fibers were dip-coated by polymethyl methacrylate-co-methacrylic acid, poly(MMA-co-MAA), which was synthesized in different molar ratios of the monomers via free-radical polymerization. Fabricated platfrom was employed for immobilization of the dengue antibody and subsequent detection of dengue enveloped
Report on carcinogens : carcinogen profiles, 12, 145-148 (2011-08-20)
Anirudh Sharma et al.
Nanotechnology, 26(13), 135102-135102 (2015-03-13)
We present non-cytotoxic, magnetic, Arg-Gly-Asp (RGD)-functionalized nickel nanowires (RGD-nanowires) that trigger specific cellular responses via integrin transmembrane receptors, resulting in dispersal of the nanowires. Time-lapse fluorescence and phase contrast microscopy showed that dispersal of 3 μm long nanowire increased by
Hong-Yong Duan et al.
Vascular, 23(4), 358-365 (2014-09-12)
To evaluate the possibility of using heparin-bonded polycaprolactone grafts to replace small-diameter arteries. Polycaprolactone was bonded with heparin. The activated partial thromboplastin time of heparin-bonded polycaprolactone grafts was determined in vitro. Small-diameter grafts were electrospun with heparin-bonded polycaprolactone and polycaprolactone
Chiara Di Bari et al.
Bioelectrochemistry (Amsterdam, Netherlands), 107, 30-36 (2015-11-03)
cathodes. Nanostructuring was provided by gold nanorods (AuNRs), which were characterized and covalently attached to electrodes made of low-density graphite. The nanostructured electrode was the scaffold for covalent and oriented attachment of ThLc. The bioelectrocatalytic currents measured for oxygen reduction
Niels E Kirkhus et al.
Environmental science. Processes & impacts, 17(7), 1257-1264 (2015-05-29)
The aim was to study exposure to airborne contaminants in oil drillers during ordinary work. Personal samples were collected among 65 drill floor workers on four stationary and six moveable rigs in the Norwegian offshore sector. Air concentrations of drilling
Qingxiu Yang et al.
Scientific reports, 5, 17727-17727 (2015-12-05)
In this work, we demonstrated a convenient and green strategy for the synthesis of highly luminescent and water-soluble carbon dots (Cdots) by carbonizing carbon precursors, i.e., Bovine serum albumin (BSA) nanoparticles, in water solution. Without post surface modification, the as-synthesized
Jianbo Liu et al.
Nanotechnology, 25(50), 505502-505502 (2014-11-26)
Protein labeling for dynamic living cell imaging plays a significant role in basic biological research, as well as in clinical diagnostics and therapeutics. We have developed a novel strategy in which the dynamic visualization of proteins within living cells is
Salita Sinlapabodin et al.
Materials science & engineering. C, Materials for biological applications, 58, 960-970 (2015-10-20)
In cell culture, a perfusion bioreactor provides effective transportation of nutrients, oxygen, and waste removal to and from the core of the scaffold. In addition, it provides mechanical stimuli for enhancing osteogenic differentiation. In this study, we used an axial
Nikhil Bhalla et al.
Biosensors & bioelectronics, 71, 121-128 (2015-04-22)
Protein kinases are cellular switches that mediate phosphorylation of proteins. Abnormal phosphorylation of proteins is associated with lethal diseases such as cancer. In the pharmaceutical industry, protein kinases have become an important class of drug targets. This study reports a
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