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31642

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Jingying Hou et al.
Experimental and molecular pathology, 96(3), 284-291 (2014-03-25)
Substantial evidence suggests that the expansion of regulatory T cells (T(regs)) plays a pivotal role in immunological evasion of tumors. Recent studies have demonstrated that a majority of tumor cells overexpress B7-H1, and this overexpression is associated with poor disease
Integration of wetland wastewater treatment with disinfection via bioelectrochemical H2O2 production.
J B A Arends et al.
Communications in agricultural and applied biological sciences, 78(1), 173-177 (2013-07-24)
Tian Wang et al.
Toxicology mechanisms and methods, 24(8), 560-566 (2014-08-20)
Escin, a natural mixture of triterpenoid saponin isolated from the seed of the horse chestnut, is reported to have a potent antiulcer activity against ethanol-induced gastric mucosal lesions. This study investigated the possible mechanisms underlying the gastroprotective effect of escin
Xiaojin Zhang et al.
International journal of oncology, 46(3), 1141-1148 (2014-12-30)
Breast cancer is the most common malignancy in women. The Notch signaling pathway has been shown to be associated with the development and progression of many human cancers, including breast cancer, but the precise mechanism remains unknown. Here, the influence
S Tiwary et al.
Oncogenesis, 3, e110-e110 (2014-07-08)
Melanoma is curable when it is at an early phase but is lethal once it becomes metastatic. The recent development of BRAF(V600E) inhibitors (BIs) showed great promise in treating metastatic melanoma, but resistance developed quickly in the treated patients, and
S M Wabaidur et al.
Luminescence : the journal of biological and chemical luminescence, 29(6), 684-688 (2014-10-23)
A sensitive flow-injection chemiluminescence method for the determination of acetylsalicylic acid is described. It is based on the enhanced chemiluminescent emission of the alkaline lucigenin–H2O2 system by acetylsalicylic acid. The difference in chemiluminescent intensity of alkaline lucigenin–H2O2 in the presence
Steven J Conrad et al.
Journal of experimental & clinical cancer research : CR, 34, 19-19 (2015-04-19)
Colorectal cancers are significant causes of morbidity and mortality and existing therapies often perform poorly for individuals afflicted with advanced disease. Oncolytic virotherapy is an emerging therapeutic modality with great promise for addressing this medical need. Herein we describe the
W M K R T W Bandara et al.
Water environment research : a research publication of the Water Environment Federation, 85(5), 387-390 (2013-06-26)
The effectiveness of degasification using a degassing membrane to improve chemical oxygen demand (COD) removal efficiency was investigated using a bench-scale upflow anaerobic sludge blanket (UASB) reactor. Vacuum degasification was able to transfer dissolved gas in the bulk liquid of
Fu-Chao Liu et al.
Shock (Augusta, Ga.), 43(5), 470-474 (2015-02-19)
Casodex (bicalutamide), an androgen receptor antagonist, is used for the treatment of prostate cancer. Recent evidences show that Akt signaling pathway exerts organ-protective effects after injury. The aim of this study was to investigate whether Akt plays any role in
Paula Santoyo-Ramos et al.
PloS one, 9(11), e112580-e112580 (2014-11-15)
This study examined the role played by hypoxia-inducible factors (HIFs) in malignant phenotype maintenance and canonical Wnt signaling. Under normoxia, we determined that both HIF-1α and HIF-2α are expressed in human colon cancer cells but not in their non-malignant counterparts.
Mohammad Parwez Ahmad et al.
Pakistan journal of pharmaceutical sciences, 28(2), 509-513 (2015-03-03)
Lipopolysaccharide (LPS) induced oxidative stress and impairment of normal physiological function generally categorized by increased anxiety and reduced mobility. Therefore, the present study was to find out the effect Methanolic extract of Asparagus racemosus (MEAR ) in lipopolysaccharide (LPS)-induced oxidative
Lydia Herrmann et al.
PloS one, 10(3), e0119423-e0119423 (2015-03-24)
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in neurons
F Q Hu et al.
Journal of biological regulators and homeostatic agents, 28(4), 649-657 (2015-01-27)
Pentraxin-3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but the function and molecular underlying mechanisms of PTX3 remain unclear. In the present study, the expression of PTX3 in
Daniel S Levic et al.
Journal of molecular medicine (Berlin, Germany), 93(2), 165-176 (2015-01-07)
Anderson disease (ANDD) or chylomicron retention disease (CMRD) is a rare, hereditary lipid malabsorption syndrome associated with mutations in the SAR1B gene that is characterized by failure to thrive and hypocholesterolemia. Although the SAR1B structure has been resolved and its
Tingting Weng et al.
American journal of respiratory and critical care medicine, 190(12), 1402-1412 (2014-10-31)
Idiopathic pulmonary fibrosis (IPF) is a deadly lung disease with few therapeutic options. Apoptosis of alveolar epithelial cells, followed by abnormal tissue repair characterized by hyperplastic epithelial cell formation, is a pathogenic process that contributes to the progression of pulmonary
Narendra Kumar et al.
Canadian journal of physiology and pharmacology, 93(1), 71-79 (2014-12-05)
Diabetes, characterized by hyperglycemia, leads to several complications through the generation of reactive oxygen species and initiates tissue damage. Pyrroloquinoline quinone (PQQ) is believed to be a strong antioxidant, as it protects cells from oxidative damage. In this study, we
Walid M Ebeid et al.
Analytical and bioanalytical chemistry, 406(26), 6701-6712 (2014-09-06)
A RP-LC method was developed and validated for simultaneous determination of the active components, azilsartan medoxomil (AZL) and chlorthalidone (CLT), in their novel antihypertensive combined recipe. The chromatographic separation was achieved on an Eclipse XDB-C18 (4.6 × 150 mm, 5 μm) column using a mobile
Rushi Gandhi et al.
American journal of physiology. Renal physiology, 307(2), F205-F221 (2014-05-16)
Efficient clearance of apoptotic cells (efferocytosis) prevents inflammation and permits repair following tissue injury. Kidney injury molecule-1 (KIM-1) is a receptor for phosphatidylserine, an "eat-me" signal exposed on the surface of apoptotic cells that marks them for phagocytic clearance. KIM-1
Fernando Henrique Borba et al.
Environmental technology, 34(5-8), 653-661 (2013-07-11)
In this work, an optimized photo-Fenton process was applied to remove pollutants from tannery industrial effluent (TIE) with its final toxicity level being assessed by a lettuce-seed-based bioassay test. A full 33 factorial design was applied for the optimization of
Angelo R F Pipi et al.
Chemosphere, 109, 49-55 (2014-05-31)
Here, solutions with 0.185mM of the herbicide diuron of pH 3.0 have been treated by electrochemical advanced oxidation processes (EAOPs) like electrochemical oxidation with electrogenerated H2O2 (EO-H2O2), electro-Fenton (EF) and UVA photoelectro-Fenton (PEF) or solar PEF (SPEF). Trials were performed
Stephen D Dingley et al.
Journal of molecular biology, 426(11), 2199-2216 (2014-02-19)
Mitochondrial DNA (mtDNA) sequence variation can influence the penetrance of complex diseases and climatic adaptation. While studies in geographically defined human populations suggest that mtDNA mutations become fixed when they have conferred metabolic capabilities optimally suited for a specific environment
Sun-Hwa Song et al.
Cardiovascular research, 103(1), 147-155 (2014-04-22)
Reactive oxygen species (ROS) are involved in a wide range of cellular processes. However, few studies have examined the generation and function of ROS in human embryonic vascular development. In this study, the sources of ROS and their roles in
K J Taylor et al.
Parasite immunology, 37(1), 23-31 (2014-11-08)
Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial
Beibei Xu et al.
Biochimica et biophysica acta, 1842(9), 1638-1647 (2014-06-11)
Nrf2 is a bZIP transcription factor regulating the expression of antioxidant and detoxification genes. We have found that Nrf2 knockout mice have an increased infarction size in response to regional ischemic reperfusion and have a reduced degree of cardiac protection
Jason M Sobota et al.
Journal of bacteriology, 196(11), 1980-1991 (2014-03-25)
In Escherichia coli, aromatic compound biosynthesis is the process that has shown the greatest sensitivity to hydrogen peroxide stress. This pathway has long been recognized to be sensitive to superoxide as well, but the molecular target was unknown. Feeding experiments
Anne Bravard et al.
Nucleic acids research, 43(2), 904-916 (2014-12-30)
The prion protein (PrP) is highly conserved and ubiquitously expressed, suggesting that it plays an important physiological function. However, despite decades of investigation, this role remains elusive. Here, by using animal and cellular models, we unveil a key role of
Pennelope K Blakely et al.
Journal of neurovirology, 21(1), 43-55 (2014-11-02)
While alphaviruses spread naturally via mosquito vectors, some can also be transmitted as aerosols making them potential bioterrorism agents. One such pathogen, western equine encephalitis virus (WEEV), causes fatal human encephalitis via multiple routes of infection and thus presumably via
Yuetan Dou et al.
Journal of bacteriology, 196(23), 4057-4070 (2014-09-17)
The adaptation of Porphyromonas gingivalis to H2O2-induced stress while inducible is modulated by an unknown OxyR-independent mechanism. Previously, we reported that the PG_2212 gene was highly upregulated in P. gingivalis under conditions of prolonged oxidative stress. Because this gene may
Yunus Emre Unsal et al.
Journal of AOAC International, 97(4), 1034-1038 (2014-08-26)
Total concentration of metal ions at trace levels does not give sufficient information about toxicity and biological availability of these elements in fertilizer samples. In the presented work, a sequential extraction procedure modified by the European Community Bureau of Reference
Daniel J O'Shannessy et al.
Oncotarget, 5(12), 3983-3995 (2014-07-02)
Tumor survival is influenced by interactions between tumor cells and the stromal microenvironment. One example is Endosialin (Tumor Endothelial Marker-1 (TEM-1) or CD248), which is expressed primarily by cells of mesenchymal origin and some tumor cells. The expression, as a
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