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M Jawad Khan et al.
Functional & integrative genomics, 15(5), 563-576 (2015-05-06)
The prepartal dietary energy level is tightly correlated with the degree of tissue mobilization that the animal experiences around parturition (giving birth). To better understand the link between the dry period dietary energy management and the inflammatory status around parturition
Yu-Xi He et al.
Molecular medicine reports, 12(2), 2291-2300 (2015-05-06)
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is a technique widely used for the quantification of mRNA transcription, It is well recognized that the reference genes used in RT-qPCR require appropriate validation to ensure that gene expression is unaffected by experimental
Francisca O Peixoto et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(1), 104-115 (2014-12-31)
BACKGROUND/ AIMS: The knowledge of the molecular network that governs fetal lung branching is an essential step towards the discovery of novel therapeutic targets against pulmonary pathologies. Lung consists of two highly branched systems: airways and vasculature. Ephrins and its
Fatai Adigun Aborode et al.
Metallomics : integrated biometal science, 7(7), 1056-1066 (2015-03-10)
Three month old Thunbergia alata were exposed for 13 days to 10 μM selenite to determine the biotransformation of selenite in their roots. Selenium in formic acid extracts (80 ± 3%) was present as selenopeptides with Se-S bonds and selenium-PC
Yuan He et al.
Investigative ophthalmology & visual science, 55(10), 6742-6755 (2014-09-13)
Oxidative stress plays an important role in health and aging. We have shown that oxidative stress impairs mitochondrial function and promotes RPE cell death in an age-dependent manner. This study investigates the role of pigment epithelium-derived factor (PEDF) in limiting
Chi Keung Lam et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6466-E6475 (2015-11-11)
The major underpinning of massive cell death associated with myocardial infarction involves opening of the mitochondrial permeability transition pore (mPTP), resulting in disruption of mitochondria membrane integrity and programmed necrosis. Studies in human lymphocytes suggested that the hematopoietic-substrate-1 associated protein
Grazielle V B Huguenin et al.
Microcirculation (New York, N.Y. : 1994), 22(8), 687-699 (2015-07-28)
To investigate the effects of dietary supplementation with GBNs on microvascular endothelial function in hypertensive and dyslipidemic patients. Ninety-one patients of both sexes aged 62.1 ± 9.3 years received 13 g/day of GBNs or a placebo for three months with
Sveta Chakrabarti et al.
PLoS genetics, 10(9), e1004659-e1004659 (2014-09-26)
The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various substrates, transcription factors of the
Suvi-Katriina Ruokonen et al.
Journal of chromatography. A, 1405, 178-187 (2015-06-15)
The effect of three phosphonium and imidazolium ionic liquids (ILs) on the interaction between liposomes and common pharmaceuticals found in wastewaters was studied. The liposomes comprised zwitterionic phosphatidyl choline and negatively charged phosphatidyl glycerol. A set of common cationic, anionic
Vishal Singh et al.
Nature communications, 6, 7113-7113 (2015-05-13)
During an inflammatory response in the gut, some commensal bacteria such as E. coli can thrive and contribute to disease. Here we demonstrate that enterobactin (Ent), a catecholate siderophore released by E. coli, is a potent inhibitor of myeloperoxidase (MPO)
Thiago C Genaro-Mattos et al.
PloS one, 10(6), e0129963-e0129963 (2015-06-23)
Caffeic acid (CA) is a phenolic compound widely found in coffee beans with known beneficial effects in vivo. Many studies showed that CA has anti-inflammatory, anti-mutagenic, antibacterial and anti-carcinogenic properties, which could be linked to its antioxidant activity. Taking in
Roman Davydov et al.
Biochemistry, 53(30), 4894-4903 (2014-07-22)
The fleeting ferric peroxo and hydroperoxo intermediates of dioxygen activation by hemoproteins can be readily trapped and characterized during cryoradiolytic reduction of ferrous hemoprotein-O2 complexes at 77 K. Previous cryoannealing studies suggested that the relaxation of cryogenerated hydroperoxoferric intermediates of
P Persson et al.
Acta physiologica (Oxford, England), 214(3), 311-318 (2015-04-22)
Diabetic patients are at increased risk for kidney disease. There is presently no clinical treatment available that effectively protects kidney function in diabetics. This study investigates whether chronic stimulation of the adenosine A2a receptor (A2a AR) protects kidney function in
Michael R Kierny et al.
PloS one, 10(4), e0124492-e0124492 (2015-04-23)
Candidate biomarkers, indicative of disease or injury, are beginning to overwhelm the process of validation through immunological means. Recombinant antibodies developed through phage-display offer an alternative means of generating monoclonal antibodies faster than traditional immunization of animals. Peptide segments of
Yohannes Wagesho et al.
SpringerPlus, 4, 107-107 (2015-03-20)
Ginger (Zingiber officinale Roscoe) is a common condiment for various foods and beverages and widely used worldwide as a spice. Its extracts are used extensively in the food, beverage, and confectionary industries in the production of products such as marmalade
Vipin Kumar et al.
Nanoscale, 7(27), 11777-11786 (2015-06-25)
The crystallographic structure and morphology of redox active transition metal oxides have a pronounced effect on their electrochemical properties. In this work, h-MoO3 nanostructures with three distinct morphologies, i.e., pyramidal nanorod, prismatic nanorod and hexagonal nanoplate, were synthesized by a
Jixiang Zhang et al.
Medical oncology (Northwood, London, England), 32(4), 101-101 (2015-03-05)
Hesperetin, a flavonoid from citrus fruits, has been proved to possess biological activity on various types of human cancers. However, few related studies on hepatocellular carcinoma are available. In this study, we aimed to investigate the effect of hesperetin on
Pascale Perret et al.
International journal of molecular sciences, 16(11), 27730-27740 (2015-11-28)
Maurocalcine (MCa) is the first natural cell penetrating peptide to be discovered in animal venom. In addition to the fact that it represents a potent vector for the cell penetration of structurally diverse therapeutic compounds, MCa also displays several distinguishing
Wen-Qing Li et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 23(8), 1579-1588 (2014-05-29)
Germline genetic variants in PLCE1 (10q23) have demonstrated consistent associations with risk of esophageal squamous cell carcinoma (ESCC) and gastric cancer among Chinese. We evaluated PLCE1 mRNA and protein expression in paired tumor-normal tissues, and their relationship with survival. PLCE1
Seishiro Hirano et al.
Toxicology and applied pharmacology, 287(3), 191-201 (2015-06-07)
Promyelocytic leukemia (PML), which is a tumor suppressor protein that nevertheless plays an important role in the maintenance of leukemia initiating cells, is known to be biochemically modified by As(3+). We recently developed a simple method to evaluate the modification
Takayuki Tanaka et al.
Journal of gastroenterology, 50(9), 975-983 (2014-12-30)
Pancreatic ductal adenocarcinoma (PDAC) is known as one of the most malignant potential diseases with poor neovascularization. By comparing PDAC to hepatocellular carcinoma (HCC), which is well vascularized, we investigated the mechanisms and tumor biological significance of the poor neovascularization
Kelly K Arthur et al.
Journal of pharmaceutical sciences, 104(4), 1548-1554 (2015-01-07)
Differential scanning calorimetry (DSC) is a useful tool for monitoring thermal stability of the molecular conformation of proteins. Here, we present an example of the sensitivity of DSC to changes in stability arising from a common chemical degradation pathway, oxidation.
Nichole K Nadermann et al.
Advanced materials (Deerfield Beach, Fla.), 27(33), 4924-4930 (2015-07-17)
Indentation of hydrated Nafion thin films reveals that both the in-plane diffusivity of water and the intrinsic permeability of the phase-segregated network decrease dramatically with decreasing film thickness. Using pore-network theory, this decrease in diffusivity is attributed to both an
Erik Berglund et al.
Experimental cell research, 326(2), 315-325 (2014-05-16)
DOG1, a Ca(2+)-activated Cl(-) channel (CaCC), was identified in 2004 to be robustly expressed in gastrointestinal stromal tumors (GIST). It was rapidly included as a tumor marker in routine diagnostics, but the functional role remained unknown. CaCCs are important regulators
Justin E Mirus et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(7), 1764-1771 (2015-01-16)
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in the United States, and its incidence is on the rise. Advanced disease is nearly uniformly lethal, emphasizing the need to identify PDA at its earliest stages. To
Seydou Sylla et al.
Microbiology and immunology, 58(7), 398-408 (2014-05-23)
Post-weaning multisystemic wasting syndrome (PMWS) associated with porcine circovirus type 2 (PCV2) has caused the swine industry significant health challenges and economic damage. Although inactivated and subunit vaccines against PMWS have been used widely, so far no DNA vaccine is
Jian Chen et al.
International journal of food microbiology, 193, 152-158 (2014-12-03)
The use of antagonistic yeasts to control postharvest pathogens is a promising alternative to fungicides. The effectiveness of the antagonists against fungal pathogens is greatly dependent on their viability, which is usually mediated by reactive oxygen species (ROS). Here, we
Eva Cuypers et al.
Forensic science international, 242, 103-110 (2014-07-23)
Today, forensic hair analysis is considered to be a standard method for identifying chronic drug users since information about drug use stored and located in hair can cover several months to even years. When interpreting these results, one should be
Aksorntong Chooruk et al.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 96(5), 519-522 (2013-06-12)
To study the prevalence and the number of lactobacilli in normal subjects and in women with bacterial vaginosis (BV). The studied subjects consisted of 60 normal and 60 BV women. The diagnosis of BV was based on at least three
Hildegunn Iversen et al.
PloS one, 10(2), e0118140-e0118140 (2015-02-27)
Enterohemorrhagic E. coli (EHEC) is associated with severe gastrointestinal disease. Upon entering the gastrointestinal tract, EHEC is exposed to a fluctuating environment and a myriad of other bacterial species. To establish an infection, EHEC strains have to modulate their gene
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