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Izabela Laczmanska et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(12), 12397-12401 (2014-09-10)
The protective effect of vitamin D against several cancers including colorectal cancer is modulated by the vitamin D receptor (VDR) and its ligand, the active form of vitamin D. VDR response has been found to play a role in various
Anne-Coline Laurent et al.
Cardiovascular research, 105(1), 55-64 (2014-11-21)
Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood mechanisms. We previously demonstrated that Exchange protein directly activated by cAMP 1 (Epac1)-induced hypertrophy in primary cardiomyocytes. Among the
James W Wynne et al.
Genome biology, 15(11), 532-532 (2014-11-16)
Bats are a major reservoir of emerging infectious viruses. Many of these viruses are highly pathogenic to humans however bats remain asymptomatic. The mechanism by which bats control viral replication is unknown. Here we utilize an integrated approach of proteomics
Sorina Motoc et al.
Journal of environmental sciences (China), 25(4), 838-847 (2013-08-09)
This work describes the electrochemical behaviour of ibuprofen on two types of multi-walled carbon nanotubes based composite electrodes, i.e., multi-walled carbon nanotubes-epoxy (MWCNT) and silver-modified zeolite-multi-walled carbon nanotubes-epoxy (AgZMWCNT) composites electrodes. The composite electrodes were obtained using two-roll mill procedure.
Chieh-Jui Tsou et al.
Nanoscale, 7(9), 4217-4225 (2015-02-13)
Continuous and simultaneous 3D single-particle movement and local pH detection in HeLa cells were demonstrated for the first time by combining fluorescent mesoporous silica nanoparticles (FMSNs) and a single-particle tracking (SPT) technique with a precision of ∼10 nm. FMSNs, synthesized
Klaus Gerwert et al.
Biochimica et biophysica acta, 1837(5), 606-613 (2013-09-24)
Protein-bound internal water molecules are essential features of the structure and function of microbial rhodopsins. Besides structural stabilization, they act as proton conductors and even proton storage sites. Currently, the most understood model system exhibiting such features is bacteriorhodopsin (bR).
Fanbin Meng et al.
International journal of oncology, 46(3), 1109-1120 (2014-12-17)
CCL18 is a chemokine that is primarily expressed in monocytes, macrophages and immature dendritic cells and plays a crucial role in immune and inflammation responses. Recently, CCL18 was found to play pivotal roles in the development of several kinds of
Esther Nkuipou-Kenfack et al.
Oncotarget, 6(33), 34106-34117 (2015-10-03)
To assess normal and pathological peptidomic changes that may lead to an improved understanding of molecular mechanisms underlying ageing, urinarypeptidomes of 1227 healthy and 10333 diseased individuals between 20 and 86 years of age were investigated. The diseases thereby comprised
Bo-Ram Kim et al.
Tissue engineering. Part A, 20(23-24), 3279-3289 (2014-06-18)
To confirm the effect of recombinant human bone morphogenetic protein-2 (BMP-2) for bone regeneration, BMP-2-loaded polycaprolactone (PCL)-gelatin (Gel)-biphasic calcium phosphate (BCP) fibrous scaffolds were fabricated using the electrospinning method. The electrospinning process to incorporate BCP nanoparticles into the PCL-Gel scaffolds
Rachel Parke-Houben et al.
Journal of materials science. Materials in medicine, 26(2), 107-107 (2015-02-11)
Three-dimensional scaffolds based on inverted colloidal crystals (ICCs) were fabricated from sequentially polymerized interpenetrating polymer network (IPN) hydrogels of poly(ethyleneglycol) and poly(acrylic acid). This high-strength, high-water-content IPN hydrogel may be suitable for use in an artificial cornea application. Development of
Kazuyuki Matsushita et al.
Oncotarget, 6(7), 5102-5117 (2015-02-12)
FUSE-binding protein (FBP)-interacting repressor (FIR) is a c-myc transcriptional suppressor. A splice variant of FIR that lacks exon 2 in the transcriptional repressor domain (FIRΔexon2) upregulates c-myc transcription by inactivating wild-type FIR. The ratio of FIRΔexon2/FIR mRNA was increased in
M O Oke et al.
Pakistan journal of biological sciences : PJBS, 16(24), 2015-2020 (2014-02-13)
The nutritional and anti-nutritional compositions of African Yam Bean (AYB) and Lima bean flours under different processing methods were determined. Nutritional and anti-nutritional properties studied include moisture content, crude protein, crude fibre, ash content, ether extract, carbohydrate, tannin, protease inhibitor
Wei Zhang-Sun et al.
FEBS letters, 589(1), 165-171 (2014-12-06)
The levels of sulfate-reducing bacteria (SRB), including Desulfovibrionaceae, in the gut increase following a fat-enriched diet. Endotoxins from gut microbiota contribute to the inflammation process, leading to metabolic diseases. Thus, we sought to characterize the lipid A structures of Desulfovibrionaceae
Weishuai Bian et al.
International journal of clinical and experimental medicine, 8(8), 13954-13961 (2015-11-10)
The aim of the present study was to explore a novel insight to determine the positive end expiratory pressure (PEEP) for sustained ventilation after lung recruitment in an acute respiratory distress syndrome (ARDS) model. Continuous infusion of oleic acid was
Yuliya K Nikitina et al.
Journal of chromatography. A, 1363, 71-78 (2014-09-04)
The adsorption of two typical hydro-organic mobile phases, with methanol and acetonitrile as the organic component, on an antibiotic based chiral stationary phase (CSP) Nautilus-E was studied by the minor perturbation method. In both cases, the excess adsorption of water
Chunna Liu et al.
Pharmacological reports : PR, 67(2), 394-398 (2015-02-26)
Urocortin (UCN) is a newly identified vascular-active peptide that has been shown to reverse cardiovascular remodeling and improve left ventricular (LV) function. The effects and mechanism of urocortin 2 (UCN2) in vivo on the electrical remodeling of left ventricle and
Yanliang Tan et al.
Health physics, 107(3), 255-260 (2014-07-30)
Generally, 88% of the freshly generated 218Po ions decayed from 222Rn are positively charged. These positive ions become neutralized by recombination with negative ions, and the main source of the negative ions is the OH- ions formed by radiolysis of
[The cutting-edge of medicine; hyponatremia and water metabolism disorders in elderly].
San-e Ishikawa
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102(7), 1807-1813 (2013-08-21)
Chang Soo Eun et al.
Helicobacter, 19(6), 407-416 (2014-07-24)
Helicobacter pylori (H. pylori) infection plays an important role in the early stage of cancer development. However, various bacteria that promote the synthesis of reactive oxygen and nitrogen species may be involved in the later stages. We aimed to determine
Yi Li et al.
SpringerPlus, 4, 637-637 (2015-11-07)
CYP3A5 and ABCB1 polymorphisms have been shown to influence tacrolimus blood concentrations and dose requirements, but the conclusion in the current reports were inconformity. Sirolimus are also metabolized by CYP3A subfamily and are substrates of the P-gp. The aim was
A Overbeck et al.
Letters in applied microbiology, 61(4), 333-338 (2015-07-21)
Industrial biotechnology uses microbiological cells to produce a wide range of products. While the organisms in question are well understood regarding their genetic and molecular properties, less is known about their mechanical properties. Previous work has established a testing procedure
Lucio Isa
Chimia, 67(4), 231-235 (2013-08-24)
Since the seminal work of Pickering and Ramsden more than a century ago, adsorption of solid micro- and nanoparticles at the interface between two fluids has been recognized as a means to enormously improve emulsion stability against coalescence. Despite their
Kevin Kennedy et al.
Current allergy and asthma reports, 13(6), 672-680 (2013-11-20)
Exposure to dampness and mold in indoor environments has received significant attention in recent research. This review focuses on studies looking at the impact of dampness, moisture and microbial agents on children's health. We then look more broadly at how
Christoph Janiak et al.
Chimia, 67(6), 419-424 (2013-08-16)
Porous coordination polymers (PCPs)/metal-organic frameworks (MOFs) are inorganic-organic hybrid materials with a permanent three-dimensional porous metal-ligand network. PCPs or MOFs are inorganic-organic analogs of zeolites in terms of porosity and reversible guest exchange properties. Microporous water-stable PCPs with high water
Rossella Melchiotti et al.
BMC medical genetics, 15, 73-73 (2014-06-28)
Extracellular ATP is a pro-inflammatory molecule released by damaged cells. Regulatory T cells (Treg) can suppress inflammation by hydrolysing this molecule via ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1), also termed as CD39. Multiple studies have reported differences in CD39+ Treg percentages
Shaoyin Wang et al.
Organic letters, 16(13), 3592-3595 (2014-06-25)
A novel Lewis acid catalyzed dehydrative [3 + 3]-annulation of readily available benzylic alcohols and propargylic alcohols was developed to give polysubstituted carbazoles and naphthalenes in moderate to good yields with water as the only byproduct. The reaction was presumed
Daniela Rigano et al.
Fitoterapia, 99, 198-203 (2014-10-07)
A new acetophenone derivative named gnaphaliol 9-O-propanoate (1) was isolated from the chloroform fraction of EtOH extract of Helichrysum italicum ssp. italicum flowers along with the five known acetophenones 12-acetoxytremetone (2), 13-(2-methylpropanoyloxy)toxol (3), [2,3-dihydro-2-[1-(hydroxymethyl)ethenyl]-5-benzofuranyl]-ethanone (4), 1-[2-[1-[(acetyloxy)methyl]ethenyl]-2,3-dihydro-3-hydroxy-5-benzofuranyl]-ethanone (5) and gnaphaliol (6).
Asya Akbar et al.
International journal of food microbiology, 188, 116-121 (2014-08-12)
Two new species of Aspergillus (A. aculeatinus, A. sclerotiicarbonarius) were previously isolated from coffee in Thailand. The objective of this study was to examine the effect of interacting environmental factors of water availability (water activity, aw) and temperature on lag
Stephen Estes et al.
Developmental neurobiology, 75(5), 435-451 (2014-09-25)
The electrical activity in developing and mature neurons determines the intracellular calcium concentration ([Ca(2+)]i), which in turn is translated into biochemical activities through various signaling cascades. Electrical activity is under control of neuromodulators, which can alter neuronal responses to incoming
Nicholas Cox et al.
Science (New York, N.Y.), 345(6198), 804-808 (2014-08-16)
The photosynthetic protein complex photosystem II oxidizes water to molecular oxygen at an embedded tetramanganese-calcium cluster. Resolving the geometric and electronic structure of this cluster in its highest metastable catalytic state (designated S3) is a prerequisite for understanding the mechanism
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