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Victor J Pai et al.
PloS one, 9(5), e97637-e97637 (2014-05-20)
Transgenic mice (named "Omega mice") were engineered to carry both optimized fat-1 and fat-2 genes from the roundworm Caenorhabditis elegans and are capable of producing essential omega-6 and omega-3 fatty acids from saturated fats or carbohydrates. When maintained on a
Shin-Yi Yang et al.
Archives of biochemistry and biophysics, 564, 43-51 (2014-12-03)
The aim of the present study aimed to investigate whether glycated bovine serum albumin (BSA) showed novel activities on the lipid-water interface. Mannosylated BSA (Man-BSA) was prepared by modification of the carboxyl groups with p-aminophenyl α-d-mannopyranoside. In contrast to BSA
Weilin Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 157-165 (2015-03-18)
Intranasal delivery is emerging as a promising alternative for oral or intravenous administration of central nervous system (CNS) drugs, such as pramipexole which is widely used for the treatment of Parkinson's disease. To evaluate the effectiveness of intranasal delivery of
Sara Jaffari et al.
Pharmaceutical research, 31(12), 3251-3264 (2014-07-13)
To investigate the agglomeration behaviour of the fine (<5.0 μm) and coarse (>12.8 μm) particle fractions of salmeterol xinafoate (SX) and fluticasone propionate (FP) by isolating aerodynamic size fractions and characterising their physicochemical and re-dispersal properties. Aerodynamic fractionation was conducted
Osmolal gap, the clue of diagnosis and role of sodium bicarbonate and hemodialysis in methanol intoxication.
Narat Srivali et al.
The American journal of emergency medicine, 32(12), 1549-1550 (2014-12-03)
Khairia M Al-Ahmary et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 154, 135-144 (2015-11-02)
Proton transfer reaction between 2-amino-4-methylpyridine (2AMP) as the proton acceptor with 2,6-dichloro-4-nitrophenol (DCNP) as the proton donor has been investigated spectrophotometrically in methanol (MeOH), acetonitrile (AN) and a binary mixture composed of 50% MeOH and 50% AN (AN-Me). The composition
Yingchun Li et al.
The American journal of pathology, 184(12), 3332-3343 (2014-10-14)
Proper differentiation of placental epithelial cells, called trophoblast, is required for implantation. Early during placentation, trophoblast cell columns help anchor the developing embryo in the uterine wall. Although proximally continuous with villous cytotrophoblast (CTB) distally, these cells differentiate into invasive
A Kuo et al.
British journal of pharmacology, 172(2), 532-548 (2014-03-20)
For patients experiencing inadequate analgesia and intolerable opioid-related side effects on one strong opioid analgesic, pain relief with acceptable tolerability is often achieved by rotation to a second strong opioid. These observations suggest subtle pharmacodynamic differences between opioids in vivo.
Katrein Schaefer et al.
PloS one, 9(12), e114824-e114824 (2014-12-06)
The prevalence of sexually transmitted infections (STIs) is often higher in females than in males. Although the reproductive cycle profoundly modulates local immunity in the female reproductive tract (FRT) system, significant gaps in our knowledge of the immunobiology of the
T Tony Yang et al.
Molecular biology of the cell, 30(7), 828-837 (2019-02-14)
Primary cilia play a vital role in cellular sensing and signaling. An essential component of ciliogenesis is intraflagellar transport (IFT), which is involved in IFT protein recruitment, axonemal engagement of IFT protein complexes, and so on. The mechanistic understanding of
Daniela Roversi et al.
ACS chemical biology, 9(9), 2003-2007 (2014-07-25)
Antimicrobial peptides (AMPs) kill bacteria mainly through the perturbation of their membranes and are promising compounds to fight drug resistance. Models of the mechanism of AMPs-induced membrane perturbation were developed based on experiments in liposomes, but their relevance for bacterial
Adnan Y Chowdhury et al.
Virology, 456-457, 300-309 (2014-06-04)
We previously found that human pegivirus (HPgV; formerly GBV-C) NS3 protease activity inhibits Human Immunodeficiency Virus (HIV) replication in a CD4+ T cell line. Given the protease׳s similarity to the Hepatitis C virus (HCV) NS3 protease, we characterized HPgV protease
Mostafa Khajeh et al.
Journal of chromatographic science, 53(7), 1217-1221 (2015-02-26)
Electromembrane extraction (EME) coupled with high-performance liquid chromatography was developed for determination of organic compounds including citric, tartaric and oxalic acid in biological samples. Organic compounds moved from aqueous samples, through a thin layer of 1-octanol immobilized in the pores
Md Nasar Mallick et al.
BioMed research international, 2015, 513875-513875 (2015-11-12)
Hydroalcoholic extract of Picrorhiza kurroa and its fractions were subjected to in vitro screening for cytotoxicity; further best active fraction (BAF) obtained was tested against Ehrlich ascites carcinoma (EAC) model in Balb/c mice after its quality control analysis. Cytotoxicities of
Gunnel H Nilsson et al.
Journal of analytical toxicology, 38(6), 327-334 (2014-05-03)
A simple liquid chromatography-tandem mass spectrometry method was validated to allow determination of zopiclone (ZOP), N-desmethylzopiclone (NDZOP), zopiclone N-oxide (ZOPNO) and 2-amino-5-chloropyridine (ACP) in urine at concentrations up to 3,000 ng/mL within 3.5 min. This method was used for quantitative
Li Wang et al.
Biological & pharmaceutical bulletin, 38(11), 1779-1787 (2015-08-14)
Candida albicans is the most common cause of invasive fungal infections in humans. The C. albicans cell wall proteins play an important role in crucial host-fungus interactions and might be ideal vaccine targets to induce protective immune response in host.
Zhi-Rong Lin et al.
Chemosphere, 141, 7-12 (2015-06-13)
In order to find out the truth of influence of solution chemistry on the oxidation efficiency of a goethite-catalyzed Fenton-like reaction, the amount of hydroxyl radicals (OH) was quantified by using coumarin as its trapping agent to produce the only
Ramzia I El-Bagary et al.
Talanta, 146, 83-92 (2015-12-24)
Two simple, sensitive, rapid, and stability-indicating liquid chromatographic (LC) methods have been developed for the determination of varenicline tartrate. They comprised the determination of varenicline (VRC) in the presence of its oxidative degradates and related impurity (N-formyl varenicline) (NFV). The
Mehran Dastmalchi et al.
Planta, 241(2), 507-523 (2014-11-12)
Soybean chalcone isomerase (CHI) family contains twelve members with unique evolutionary background, expression patterns and is compartmentalized to specific subcellular locations. The phenylpropanoid pathway produces a diverse array of plant natural products. A key branch-point enzyme, chalcone isomerase, catalyzes the
Mi-Ri-Nae Lee et al.
Marine pollution bulletin, 99(1-2), 157-165 (2015-08-04)
Twelve organotins (methyl-, octyl-, butyl-, and phenyl-tin), and eight tin-free antifouling paints and their degradation products were measured in marine sediments from the Korean coastal area, and Busan and Ulsan bays, the largest harbor area in Korea. The total concentration
Patrick Neiens et al.
ChemMedChem, 10(11), 1924-1931 (2015-09-04)
MS Binding Assays are a label-free alternative to radioligand binding assays. They provide basically the same capabilities as the latter, but an unlabeled reporter ligand is used instead of a radioligand. The study presented herein describes the development of MS
Pinaki B Patel et al.
Indian journal of experimental biology, 53(3), 152-157 (2015-04-16)
In systemic therapy, chemotherapeutic drugs, often, cause considerable side effects; and combination of natural compounds lessen the extent of such effects. In the present study, combined effect of citral and 5-fluorouracil was studied in Schizosaccharomyces pombe cells. The antagonistic combination
Jevgenija Ponomarenko et al.
Phytochemistry, 103, 178-187 (2014-04-08)
A series of diarylheptanoids, namely 1,7-bis-(3,4-dihydroxyphenyl)-heptan-3-one-5-O-D-xylopyranoside (oregonin), 1,7-bis-(3,4-dihydroxyphenyl)-3-hydroxyheptane-5-O-β-D-xylopyranoside and 1,7-bis-(4-hydroxyphenyl)-heptane-3-one-5-O-β-D-glucopyranoside (platyphylloside), were isolated from the bark of alder family trees, a species widely spread over in Europe. As antioxidants, these natural polyphenols have a promising potential in various fields of
Jayanta K Das et al.
Microvascular research, 98, 126-138 (2015-02-11)
While significant progress has been made to advance our knowledge of microvascular lesion formation, yet the investigation of how stem-like cells may contribute to the pathogenesis of microvascular diseases is still in its infancy. We assessed whether the inhibitor of
Pimsumon Jiamboonsri et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 12-17 (2015-02-24)
Methyl gallate (MG) and pentagalloyl glucopyranose (PGG) are bioactive phenolic compounds that are widely distributed in herbs and plant foods. Their potential activities include anti-oxidant, anti-inflammatory, anti-cancer, anti-bacterial and anti-viral activities. However, knowledge concerning the pharmacokinetic characteristics of MG and
Tonggui Ding et al.
Basic & clinical pharmacology & toxicology, 116(5), 385-389 (2014-09-25)
This study firstly investigated the effects of cucurbitacin E (CuE), a tetracyclic triterpene compound from Cucurbitaceae, on the pharmacokinetics (PK) and pharmacodynamics (PD) of warfarin, a model CYP2C probe substrate, in the rat. In PK studies, the concentration of warfarin
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in
Amr A Abdeen et al.
Tissue engineering. Part A, 20(19-20), 2737-2745 (2014-04-08)
The secretion of trophic factors that promote angiogenesis from mesenchymal stem cells (MSCs) is a promising cell-based therapeutic treatment. However, clinical efficacy has proved variable, likely on account of ill-defined cell delivery formulations and the inherent complexity of cellular secretion.
Anto Budiharjo et al.
PloS one, 9(5), e98267-e98267 (2014-05-23)
Bacillus amyloliquefaciens ssp. plantarum FZB42 represents the prototype of Gram-positive plant growth promoting and biocontrol bacteria. In this study, we applied transposon mutagenesis to generate a transposon library, which was screened for genes involved in multicellular behavior and biofilm formation
Yumao Jiang et al.
Journal of ethnopharmacology, 159, 102-112 (2014-12-03)
The root of Panax ginseng C.A. Meyer (Family Araliaceae) is an important medicinal plant which has been employed as a panacea for more than 2,000 years in China. It has the actions of invigorating primordial qi, recovering pulse and desertion
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