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Dimitrios Karvelis et al.
Journal of AOAC International, 97(6), 1519-1525 (2015-01-30)
A novel, fast, and sensitive stability-indicating HPLC method was developed, fully validated, and applied to the simultaneous determination of aliskiren and hydrochlorothiazide in a combined formulation. Effective chromatographic separation was achieved using a phenyl analytical column with isocratic elution using
Francisco de Borja Callejas et al.
PloS one, 9(6), e100537-e100537 (2014-06-20)
Primary human airway epithelial cells cultured in an air-liquid interface (ALI) develop a well-differentiated epithelium. However, neither characterization of mucociliar differentiation overtime nor the inflammatory function of reconstituted nasal polyp (NP) epithelia have been described. 1st) To develop and characterize
Ala Muala et al.
Particle and fibre toxicology, 12, 33-33 (2015-10-30)
Smoke from combustion of biomass fuels is a major risk factor for respiratory disease, but the underlying mechanisms are poorly understood. The aim of this study was to determine whether exposure to wood smoke from incomplete combustion would elicit airway
Christophe Glorieux et al.
Redox biology, 38, 101780-101780 (2020-11-11)
K-ras mutations are major genetic events that drive cancer development associated with aggressive malignant phenotypes, while expression of the immune checkpoint molecule PD-L1 plays a key role in cancer evasion of the immune surveillance that also profoundly affects the patient
Eiji Matsuura et al.
Journal of neuropathology and experimental neurology, 74(1), 2-14 (2014-12-04)
Activated human T-lymphotropic virus type-1 (HTLV-1)-specific CD8-positive cytotoxic T lymphocytes (CTLs) are markedly increased in the periphery of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an HTLV-1-induced inflammatory disease of the CNS. Although virus-specific CTLs play a pivotal role to
Ana Paula Dias Demasi et al.
Virchows Archiv : an international journal of pathology, 463(1), 47-55 (2013-06-06)
B cell malignancies are classified according to the postulated differentiation stage of the originating cell. During differentiation, structural and molecular changes occur to support massive processing of immunoglobulin in the endoplasmic reticulum (ER) of plasma cells at the final stage.
Tadanobu Takahashi et al.
Journal of virology, 88(15), 8445-8456 (2014-05-16)
Some animal influenza A viruses (IAVs) bind not only to N-acetylneuraminic acid (Neu5Ac) but also to N-glycolylneuraminic acid (Neu5Gc), which has been discussed as a virus receptor. Human cells cannot synthesize Neu5Gc due to dysfunction of the CMP-Neu5Ac hydroxylase (CMAH)
Wensi Zhang et al.
Nanoscale, 7(44), 18364-18378 (2015-10-28)
Molybdenum disulfide (MoS2) is a typical layered transition-metal dichalcogenide material, which has aroused a great deal of interest in the past few years. Recently, more and more attention has been focused on the synthesis and applications of MoS2-based nanocomposites. In
Panjaphorn Nimmanee et al.
International journal of medical microbiology : IJMM, 305(1), 65-74 (2014-12-04)
Eukaryotes utilize stress activated protein kinase (SAPK) pathways to adapt to environmental stress, including heat, osmotic, oxidative or nutrient stresses. Penicillium marneffei (Talaromyces marneffei), the dimorphic pathogenic fungus that can cause disseminated mycosis in HIV-infected patients, has to encounter various
Jingmei Hou et al.
Scientific reports, 5, 16922-16922 (2015-11-21)
Spermatogonial stem cells (SSCs) have significant applications in both reproductive and regenerative medicine. However, primary human SSCs are very rare, and a human SSC line has not yet been available. In this study, we have for the first time reported
Nizar Hijaze et al.
Journal of leukocyte biology, 110(2), 343-356 (2020-11-19)
Treatment of solid tumors is often hindered by an immunosuppressive tumor microenvironment (TME) that prevents effector immune cells from eradicating tumor cells and promotes tumor progression, angiogenesis, and metastasis. Therefore, targeting components of the TME to restore the ability of
André Ferreira-da-Silva et al.
PloS one, 10(3), e0122308-e0122308 (2015-03-31)
Oncocytic cell tumors are characterized by the accumulation of morphologically abnormal mitochondria in their cells, suggesting a role for abnormal mitochondrial biogenesis in oncocytic cell transformation. Little is known about the reason for the dysmorphology of accumulated mitochondria. The proteins
Sukrutha Chettimada et al.
American journal of physiology. Lung cellular and molecular physiology, 308(3), L287-L300 (2014-12-07)
Severe pulmonary hypertension is a debilitating disease with an alarmingly low 5-yr life expectancy. Hypoxia, one of the causes of pulmonary hypertension, elicits constriction and remodeling of the pulmonary arteries. We now know that pulmonary arterial remodeling is a consequence
Mingyi Yang et al.
Scientific reports, 5, 17409-17409 (2015-12-01)
The oxidation resistance gene 1 (OXR1) is crucial for protecting against oxidative stress; however, its molecular function is unknown. We employed RNA sequencing to examine the role of human OXR1 for genome wide transcription regulation. In total, in non-treated and
Dongmei Wang et al.
Cellular and molecular neurobiology, 34(8), 1209-1221 (2014-08-20)
The role of mitochondrial dysfunction and oxidative stress has been well-documented in Alzheimer's disease (AD). Bioflavonoids are being utilised as neuroprotectants in the treatment of various neurological disorders, including AD. Therefore, we conducted this current study in order to explore
Satoko Baba et al.
Journal of pharmacological sciences, 127(3), 326-331 (2015-04-04)
Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their
Jingming Zhou et al.
Biochimica et biophysica acta, 1853(2), 370-376 (2014-12-03)
Histone deacetylase 4 (HDAC4) is a critical negative regulator for chondrocyte hypertrophy by binding to and inhibiting Runx2, a critical transcription factor for chondrocyte hypertrophy. It is unclear how HDAC4 expression and stability are regulated during growth plate development. We
Christian Schafroth et al.
Oncotarget, 6(39), 41453-41463 (2015-10-27)
VE1 is a monoclonal antibody detecting mutant BRAFV(600E) protein by immunohistochemistry. Here we aim to determine the inter-observer agreement and concordance of VE1 with mutational status, investigate heterogeneity in colorectal cancers and metastases and determine the prognostic effect of VE1
Eun Chul Kim et al.
Experimental eye research, 127, 20-25 (2014-06-22)
The present study evaluated survival effects of N-acetylcysteine (NAC) on cultured corneal endothelial cells exposed to oxidative and endoplasmic reticulum (ER) stress and in a mouse model of early-onset Fuchs endothelial corneal dystrophy (FECD). Cultured bovine corneal endothelial cell viability
Sumi Park et al.
PloS one, 9(6), e99723-e99723 (2014-06-14)
Gonadotropin-releasing hormone-I (GnRH-I) has attracted strong attention as a hormonal therapeutic tool, particularly for androgen-dependent prostate cancer patients. However, the androgen-independency of the cancer in advanced stages has spurred researchers to look for new medical treatments. In previous reports, we
Ying Zhang et al.
Journal of the American Society for Mass Spectrometry, 26(3), 526-529 (2014-12-19)
Unlike small-molecule drugs, the size and dynamics of protein therapeutics challenge existing methods for assessing their high order structures (HOS). To extend fast photochemical oxidation of proteins (FPOP) to protein therapeutics, we modified its platform by introducing a mixing step
Jason M Sobota et al.
Journal of bacteriology, 196(11), 1980-1991 (2014-03-25)
In Escherichia coli, aromatic compound biosynthesis is the process that has shown the greatest sensitivity to hydrogen peroxide stress. This pathway has long been recognized to be sensitive to superoxide as well, but the molecular target was unknown. Feeding experiments
Deepak Kumar et al.
Research in microbiology, 166(1), 20-27 (2014-12-23)
The rpb7(+) gene encodes the seventh largest subunit of RNA polymerase II and is essential for survival of yeast cells. To gain insight into its functions, we expressed rpb7(+) under the control of the nmt1 promoter and investigated its role
E Paoletti et al.
Environmental pollution (Barking, Essex : 1987), 193, 1-5 (2014-07-01)
Ethylenediurea (EDU) is the most common chemical used to prevent ozone (O3) injury on vegetation. Despite considerable research, its mode of action remains elusive and gene expression has not been studied. Transcripts of major antioxidant enzymes (catalase, glutathione reductase, glutathione
Adina Daniela Iancu et al.
Roumanian archives of microbiology and immunology, 71(4), 201-220 (2013-06-13)
Type 1 diabetes mellitus (T1DM), one of the most prevalent chronic diseases is characterized by the progressive destruction of pancreatic beta cells, leading to insulin deficiency and hyperglycemia. Studies performed on diabetic subjects with prolonged hyperglycemia showed the oxidative stress
Anne Bravard et al.
Nucleic acids research, 43(2), 904-916 (2014-12-30)
The prion protein (PrP) is highly conserved and ubiquitously expressed, suggesting that it plays an important physiological function. However, despite decades of investigation, this role remains elusive. Here, by using animal and cellular models, we unveil a key role of
Giuseppina Basini et al.
Regulatory peptides, 189, 22-30 (2014-02-18)
Apart from the well established role of prolactin (PRL) in the control of mammary development and lactation, this hormone appears to possess a variety of physiological functions and evidence exists about its expression in many extra-pituitary sites. This experimental work
Tugba Olmez-Hanci et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 70(6), 1056-1064 (2014-09-27)
Photo-Fenton-like treatment of the commercially important naphthalene sulphonate K-acid (2-naphthylamine-3,6,8-trisulphonic acid) was investigated using UV-C, UV-A and visible light irradiation. Changes in toxicity patterns were followed by the Vibrio fischeri bioassay. Rapid and complete degradation of K-acid accompanied with nearly
Ozlen Saglam et al.
Human pathology, 45(6), 1269-1275 (2014-04-29)
Cysteine-rich protein 61, connective tissue growth factor, and nephroblastoma overexpressed gene (CCN) comprise a family of matricellular proteins that have multiple physiologic functions including development, tissue repair, cell adhesion, migration, and proliferation. The expression of CCN1, cyclin D1, β-catenin, and
T Kurashige et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(3), 194-199 (2014-09-03)
Recently published articles have reported the controversial data regarding expression of aldehyde dehydrogenase isozyme 1A1 (ALDH1A1), a potential candidate marker for normal and cancer stem cells (CSCs), in thyroid tissues. These data prompted us to re-evaluate expression of ALDH1A1 in
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