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Sonam Verma et al.
Med (New York, N.Y.), 2(5), 575-590 (2021-04-20)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection appears to increase the risk of adverse pregnancy outcomes, such as pre-eclampsia in pregnant women. The mechanism(s) by which this occurs remains unclear. We investigated the pathophysiology of SARS-CoV-2 at maternal-fetal interface
Wiktor A Janczewski et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5454-5465 (2013-03-29)
Postsynaptic inhibition is a key element of neural circuits underlying behavior, with 20-50% of all mammalian (nongranule) neurons considered inhibitory. For rhythmic movements in mammals, e.g., walking, swimming, suckling, chewing, and breathing, inhibition is often hypothesized to play an essential
Simon Kaja et al.
Experimental eye research, 138, 159-166 (2015-06-07)
Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic nerve head where they contribute critically to extracellular matrix synthesis during development and throughout life. In glaucoma, and in related disorders affecting the optic nerve
Hideki Kondo et al.
Journal of virology, 87(13), 7423-7434 (2013-04-26)
Orchid fleck virus (OFV) has a unique two-segmented negative-sense RNA genome that resembles that of plant nucleorhabdoviruses. In infected plant cells, OFV and nucleorhabdoviruses induce an intranuclear electron-lucent viroplasm that is believed to be the site for virus replication. In
Xing Tian et al.
Cellular and molecular neurobiology, 35(3), 335-344 (2014-10-30)
Accumulated evidence has shown that excessive reactive oxygen species (ROS) have been implicated in neuronal cell death related with various chronic neurodegenerative disorders. This study was designed to explore neuroprotective effects of ethyl acetate extract of Arctium lappa L. roots
Clea Bárcena et al.
Methods in molecular biology (Clifton, N.J.), 965, 243-251 (2013-01-09)
Gene mutations that cause defects in the nuclear envelope are responsible for progeroid syndromes, characterized by exacerbated cell senescence and accelerated aging. Consequently, morphological abnormalities of the nucleus represent a cellular phenotype whose analysis allows for both the characterization of
Judith Guasch et al.
Advanced materials (Deerfield Beach, Fla.), 27(25), 3737-3747 (2015-05-20)
Orthogonally functionalized binary micropatterned substrates are produced using a novel protocol. The use of adequate peptido-mimetics enables an unprecedented segregation of purified αvβ3 and α5β1 integrins in adjacent microislands and evidences the preference of U2OS cells to colocalize such receptors.
Kohei Sasaki et al.
PloS one, 10(3), e0121205-e0121205 (2015-03-21)
It is generally accepted that live attenuated influenza vaccine (LAIV) has the potential for use as a vaccination against flu. In this study, we demonstrated the nature of an influenza A virus (IAV) mutant induced by treating the IAV with
María M Milesi et al.
Molecular and cellular endocrinology, 401, 248-259 (2014-12-09)
We investigated whether neonatal exposure to low doses of endosulfan affects fertility and uterine functional differentiation at pre-implantation in rats. Newborn female rats received the vehicle, 0.2 µg/kg/d of diethylstilbestrol (DES), 6 µg/kg/d of endosulfan (Endo6) or 600 µg/kg/d of endosulfan (Endo600) on
Huifang Zhou et al.
Biomaterials, 35(26), 7398-7406 (2014-06-17)
The main functions of the conjunctiva, an essential part of the ocular surface, are to maintain the equilibrium of the tear film and to protect the eye. Upon injuries, the prerequisite to successful ocular surface repair is conjunctival reconstruction. Tissue
Yang Li et al.
Cancer letters, 355(1), 130-140 (2014-09-15)
Epithelial-to-mesenchymal transition (EMT) is considered to play an essential role in progression and metastasis. This study aims to investigate the expression and underlying molecular targets of high-mobility group AT-hook 2 (HMGA2) in the progression of colon cancer. The expression of
Qi-Qiang Guo et al.
The EMBO journal, 39(10), e103111-e103111 (2020-03-19)
The homeostatic link between oxidative stress and autophagy plays an important role in cellular responses to a wide variety of physiological and pathological conditions. However, the regulatory pathway and outcomes remain incompletely understood. Here, we show that reactive oxygen species
Koji Itahana et al.
Methods in molecular biology (Clifton, N.J.), 965, 143-156 (2013-01-09)
Most normal human cells have a finite replicative capacity and eventually undergo cellular senescence, whereby cells cease to proliferate. Cellular senescence is also induced by various stress signals, such as those generated by oncogenes, DNA damage, hyperproliferation, and an oxidative
Imran S Khan et al.
The Journal of experimental medicine, 211(5), 761-768 (2014-04-23)
Thymic central tolerance is a critical process that prevents autoimmunity but also presents a challenge to the generation of anti-tumor immune responses. Medullary thymic epithelial cells (mTECs) eliminate self-reactive T cells by displaying a diverse repertoire of tissue-specific antigens (TSAs)
Zhi-Qi Song et al.
CNS neuroscience & therapeutics, 20(8), 737-747 (2014-03-19)
Prion diseases are a group of infectious neurodegenerative diseases characterized by neuronal death and degeneration. Human leukocyte antigen-B-associated transcript 3 (BAT3) is an important apoptosis regulator. We therefore investigated the interactions between BAT3 and prion protein and the potential role
Songyi Lee et al.
The Laryngoscope, 125(8), 1900-1907 (2015-04-22)
The larynx is susceptible to irradiation, which causes significant vocal fold (VF) edema and dehydration shortly after radiotherapy for head and neck cancers. However little is known about radiation-induced damage to VF liquid homeostasis. To evaluate the effects of irradiation
Hong Ma et al.
Oncology reports, 33(3), 1161-1170 (2015-01-13)
The aim of the present study was to explore the efficacy and mechanism of the radiosensitisation of icotinib hydrochloride (IH), a novel oral epidermal growth factor receptor-tyrosine kinase activity inhibitor, by evaluating the changes in tumour cell double-strand breaks (DSBs)
Gongshi Bai et al.
Molecular cell, 78(6), 1237-1251 (2020-05-23)
DNA replication stress can stall replication forks, leading to genome instability. DNA damage tolerance pathways assist fork progression, promoting replication fork reversal, translesion DNA synthesis (TLS), and repriming. In the absence of the fork remodeler HLTF, forks fail to slow
Weiguo Xu et al.
Biomaterials, 54, 72-86 (2015-04-25)
Recently, chemotherapy has been one of the most important therapeutic approaches for malignant tumors. The tumor tissular or intracellular microenvironment-sensitive polymer-doxorubicin (DOX) conjugates demonstrate great potential for improved antitumor efficacy and reduced side effects. In this work, the acid-sensitive dextran-DOX
Haitao Yu et al.
Toxicology and applied pharmacology, 280(3), 502-510 (2014-09-10)
Ahr activation is known to be associated with synovitis and exacerbated rheumatoid arthritis (RA), but its contributions to bone loss have not been completely elucidated. Osteoblast proliferation and differentiation are abnormal at the erosion site in RA. Here, we reported
Jeyoung Bang et al.
Biochemical and biophysical research communications, 456(4), 884-890 (2014-12-23)
The 15-kDa selenoprotein (Sep15) has been implicated in etiology of some types of cancer. Herein, inducible RNAi cell lines were established and cell morphology and motility were analyzed. The majority of Sep15-deficient cells (>95%) formed membrane blebs in a dynamic
Jeppe Nørgaard Poulsen et al.
Experimental cell research, 336(1), 94-99 (2015-05-23)
Communications between satellite glial cells and neighboring neurons within sensory ganglia may contribute to neuropathic and inflammatory pain. To elucidate the role of satellite glial cells in chemotherapy-induced pain, we examined the effects of oxaliplatin on the gap junction-mediated coupling
Jin Zhao et al.
International journal of biological macromolecules, 56, 106-113 (2013-02-07)
Small-diameter vascular grafts can easily lead to thrombosis and intimal hyperplasia. So the rate of the long-term patency is not satisfactory. Scaffolds that can support the growth of cells and remain stable and passable in vivo are in great demand.
Berta Alcover-Sanchez et al.
Glia, 69(3), 619-637 (2020-10-04)
Fast synaptic transmission in vertebrates is critically dependent on myelin for insulation and metabolic support. Myelin is produced by oligodendrocytes (OLs) that maintain multilayered membrane compartments that wrap around axonal fibers. Alterations in myelination can therefore lead to severe pathologies
Kazuaki Nakajima et al.
PloS one, 10(7), e0133308-e0133308 (2015-07-18)
Cell transplantation therapy will mean a breakthrough in resolving the donor shortage in cardiac transplantation. Cardiomyocyte (CM) transplantation, however, has been relatively inefficient in restoring cardiac function after myocardial infarction (MI) due to low engraftment of transplanted CM. In order
Christian Held et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 83(4), 409-418 (2013-01-12)
To evaluate macrophage spreading in immunofluorescence images of macrophages for surface protein CD11b and nuclear counterstaining with DAPI, it is necessary to measure the size of the macrophages at different time points after stimulation. Manual evaluation of fluorescent micrographs is
Karl Olsson et al.
Skeletal muscle, 5, 26-26 (2015-08-25)
In skeletal muscle, intracellular Ca(2+) is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, human myotubes have been extensively employed for studies of Ca(2+)-dependent processes
Subhadip Mukhopadhyay et al.
Acta pharmacologica Sinica, 35(6), 814-824 (2014-05-06)
Abrus agglutinin (AGG) from the seeds of Indian medicinal plant Abrus precatorius belongs to the class II ribosome inactivating protein family. In this study we investigated the anticancer effects of AGG against human hepatocellular carcinoma in vitro and in vivo.
Wilma H M Hoevenaar et al.
Nature communications, 11(1), 1501-1501 (2020-03-22)
Most human cancers are aneuploid, due to a chromosomal instability (CIN) phenotype. Despite being hallmarks of cancer, however, the roles of CIN and aneuploidy in tumor formation have not unequivocally emerged from animal studies and are thus still unclear. Using
Marcus Gutmann et al.
ACS biomaterials science & engineering, 5(1), 215-233 (2019-01-14)
Metabolic glycoengineering allows insertion of non-natural monosaccharides into glycan structures during biosynthesis thereby enabling extracellular matrices (ECMs), cell surfaces, or tissues for decoration with functional cues with ultimate spatial control while deploying aqueous and toxicologically benign coupling chemistries. In this
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